Green Synthesis of Nickel Oxide Nanoparticles from Berberis balochistanica Stem for Investigating Bioactivities

Uddin, Siraj; Safdar, Luqman Bin; Anwar, Saeed; Iqbal, Javed; Laila, Sabiha; Abbasi, Banzeer Ahsan; Saif, Muhammad Saqib; Ali, Maroof; Rehman, Abdul; Basit, Abdul; Wang, Yong; Quraishi, Umar Masood

doi:10.3390/molecules26061548

Cited by 71 publications

(45 citation statements)

References 41 publications

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“…In comparison with the standard drug doxycycline, the bark extract showed significant effectiveness against both Gram-positive and Gram-negative bacteria, followed by the leaf and root extracts (Figure 1). The results of the current study were in agreement with those previously reported (Uddin et al, 2021) and relatively higher than those found in the literature (Kakar et al, 2012). However, Pervez et al (2019) evaluated the antibacterial potential of berberisinol that exhibited a significant activity against E. coli, S. aureus, and S. pyogenes, a moderate activity against B. subtilis and K. pneumoniae, and a weak activity against P. aeruginosa.…”

Section: Discussionsupporting

confidence: 94%

Elucidating Therapeutic and Biological Potential of Berberis baluchistanica Ahrendt Bark, Leaf, and Root Extracts

2022

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Berberis baluchistanica Ahrendt is a medicinal plant known to have potential for the treatment of various diseases. In the present study, the ethanolic extracts of the bark, leaves, and roots of B. baluchistanica plant were evaluated for in vitro antimicrobial, anti-leishmanial, anticancer, and anti-inflammatory activities. The antibacterial and antifungal activities were determined by agar mix and agar well diffusion method. All extracts showed potential activity against the target bacteria (Bacillus subtilis, Bacillus licheniformis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Rhodococcus erythropolis, Salmonella typhi, and Staphylococcus aureus) and fungal strains (Aspergillus flavus, Aspergillus niger, and Mucor mucedo). S. aureus proved to be the most sensitive strain for each extract, with a maximum zone of inhibition for bark at 23 ± 0.12 mm, for leaves at 22 ± 0.36 mm, and for root extracts at 20.21 ± 0.06 mm). The minimum inhibitory concentration values of B. baluchistanica bark, leaves, and roots for different target bacterial strains ranged from 1.56 to 25 mg ml–1, and the minimum bactericidal concentrations were in the range of 3.12 to 25 mg ml–1, respectively. The root extract possessed potent antifungal activity against A. flavus with 83% of growth inhibition, A. niger with 80%, and M. mucedo with 73%. The bark extract was found active against M. mucedo with 86% of inhibition, followed by 70% against A. flavus and 60% against A. niger. The leaf extract showed a significant response by 83% inhibition against M. mucedo, followed by A. flavus and A. niger with 73 and 72% inhibition, respectively. In an anti-leishmanial bioassay, the inhibitory concentration (IC50) was observed for each extract against Leishmania major. The bark showed good activity (IC50 = 4.95 ± 0.36 mg/ml), followed by the roots (IC50 = 7.07 ± 0.18 mg/ml) and the leaves (IC50 = 8.25 ± 0.29 mg/ml). An evaluation of anticancer activity was done by using MTT cell assay against HeLa cell line. Upon comparing the values of each extract to the standard, it was revealed that the ethanolic bark extract showed the highest anticancer activity with IC50 = (12 ± 0.15 μg/ml), followed by the roots (14 ± 0.15 μg/ml) and the leaves (17 ± 0.21 μg/ml), respectively. The anti-inflammatory assay was undertaken by the inhibition of albumin denaturation activity, proteinase inhibitory activity, and heat-induced hemolysis activity. The IC50 value for protein denaturation of the bark was IC50 = 0.64 ± 0.25 mg/ml, followed by the roots (0.67 ± 0.21 mg/ml) and the leaves (0.73 ± 0.13 mg/ml). The proteinase inhibitory activity of the bark extract was IC50 = 0.55 ± 0.12 mg/ml, followed by the leaves (0.62 ± 0.23 mg/ml) and the roots (0.69 ± 0.15 mg/ml), respectively. For heat-induced hemolysis assay, the bark showed the lowest IC50 value (0.48 ± 0.15 mg/ml) compared to the leaves (0.52 ± 0.35 mg/ml) and the roots (0.58 ± 0.05 mg/ml) of the plant. All analyzed parts of the B. baluchistanica plant showed significant biological activities which make the plant medicinally important and a good candidate for the isolation of antimicrobial, inflammatory, and anticancer compounds. Further studies may lead us to determine the active compounds responsible for the biological activities of the plant extracts.

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Section: Discussionsupporting

confidence: 94%

Elucidating Therapeutic and Biological Potential of Berberis baluchistanica Ahrendt Bark, Leaf, and Root Extracts

2022

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“…Plant materials and products have abundant amounts of these antioxidant compounds ( Iqbal et al, 2018a , Iqbal et al, 2018b , Iqbal et al, 2018c ). Many plant-containing phytochemicals have been used in the treatment of hepatic and renal diseases, either given independently or collectively ( Karakuş et al, 2017 , Usman et al, 2020 , Hameed et al, 2021 , Uddin et al, 2021 ). Two such phytochemical-rich and antioxidant-rich medicinal plants reported for their significant antioxidant, anti-inflammatory, hepatoprotective ( Ali et al, 2017 , Ali et al, 2018b ), antimicrobial ( Ali et al, 2018a , Ullah et al, 2015 ), anticancer and wound healing ( Ali et al, 2021c , Ali et al, 2021d ) potential is Parrotiopsis jacquemontiana (Decne) Rehder and Periploca hydaspidis Falc.…”

Section: Introductionmentioning

confidence: 99%

Chemical characterization and evaluation of the nephroprotective potential of Parrotiopsis jacquemontiana (Decne) Rehder and Periploca hydaspidis Falc crude extract in CCl4-induced Male Sprague-Dawley Rats

Ali

Khan

Iqbal

et al. 2022

Saudi Journal of Biological Sciences

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“…Utilization of therapeutic spices as antiquated prescription is one of the consistently utilized practices in subcontinent. Plants have consistently been a wellspring of fix to various infections because of essence of numerous phytochemical compounds [1]. Medications that are acquired from home grown sources have a striking impact in forestalling and relieving deadly illnesses.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of three medicinally important plants (Berberis balochistanica, Thymus serpyllum and Salvia bucharica) of Shudden, Mazhoo Tehsil Nana Sab area, District Pishin, Balochistan-Pakistan

Idrees¹

2022

PAB

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The objective of this research was to investigate the antimicrobial capability of three significant plant species i.e, Berberis balochistanica, Thymus serpyllum and Salvia bucharica. The root of B. balochistanica, the whole plant of T.serpylum and leaves of S.bucharica used for this research purposes at the area of Shudden, Mazhoo Tehsil Nana Sab area District Pishin, Balochistan. The topic area is fully rich by vegetation through the said three research species. The extracts of aforementioned parts of plants were subjected to agar well diffusion method. T. serpyllum plants have the high influential antimicrobial activity specially antibacterial in following bacterial strains (Escherichia coli, Staphylococcus aureus, Staphylococcus albus,Bacillus subtilis and Slmonilatyphae).The whole plant of S. bucharica also have the antibacterial activity against the different bacterial strains (S. aureus, S.t yphae, B. subtilis, E.coli and Pseudomonas aeroginosa).The roots of B.balochistanica have the antimicrobial activities especially against bacteria strains (B. subtilis, P. aeroginosa, Striptococcus pyogenes, E. coli and S. aureus). Resultantly, either the whole plants of T. serpyllum and leaves of S. bucharica or the roots of B. balochistanica, have the highly influential role against bacteria. The examination region has the bountiful number of B. balochistanica, S. bucharica and T. seripyllum which are never examined by analysts. The various parts of these previously mentioned plants have exceptionally substance of synthetics which resist the microorganisms particularly various kinds of microbes. Thus, it is inferred that the exploration plants may be conceivably utilized in numerous applications because of their antimicrobial properties.

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Green Synthesis of Nickel Oxide Nanoparticles from Berberis balochistanica Stem for Investigating Bioactivities

Cited by 71 publications

References 41 publications

Elucidating Therapeutic and Biological Potential of Berberis baluchistanica Ahrendt Bark, Leaf, and Root Extracts

Elucidating Therapeutic and Biological Potential of Berberis baluchistanica Ahrendt Bark, Leaf, and Root Extracts

Chemical characterization and evaluation of the nephroprotective potential of Parrotiopsis jacquemontiana (Decne) Rehder and Periploca hydaspidis Falc crude extract in CCl4-induced Male Sprague-Dawley Rats

Antimicrobial activity of three medicinally important plants (Berberis balochistanica, Thymus serpyllum and Salvia bucharica) of Shudden, Mazhoo Tehsil Nana Sab area, District Pishin, Balochistan-Pakistan

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