Green Chemistry Articles of Interest to the Pharmaceutical Industry

Amarnath, L.; Andrews, Ian P.; Bandichhor, Rakeshwar; Bhattacharya, Apurba; Dunn, Peter J.; Hayler, John; Hinkley, William; Holub, Nicole; Hughes, David L.; Humphreys, Luke; Kaptein, Bernard; Krishnen, Hare; Lorenz, Kurt; Mathew, Suju; Nagaraju, G.; Rammeloo, Thomas; Richardson, Paul; Wang, Lijun; Wells, Andrew S.; White, Timothy

doi:10.1021/op300068d

Cited by 18 publications

(3 citation statements)

References 14 publications

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“…It is increasingly important in pharmaceutical chemistry, being present in 25% of available drugs, with amidation reactions being among the most commonly used reactions in medicinal chemistry. There is considerable interest in the development of new approaches to direct amidation, , and organizations such as the ACS Green Chemistry Institute Pharmaceutical Roundtable have indicated that amide bond formation is one of the most important reactions used in industry for which better reagents are required . Although there are a large range of reagents and strategies for amide bond formation available, few can really be considered ideal.…”

Section: Introductionmentioning

confidence: 99%

Direct Synthesis of Amides from Carboxylic Acids and Amines Using B(OCH₂CF₃)₃

2013

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B(OCH2CF3)3, prepared from readily available B2O3 and 2,2,2-trifluoroethanol, is as an effective reagent for the direct amidation of a variety of carboxylic acids with a broad range of amines. In most cases, the amide products can be purified by a simple filtration procedure using commercially available resins, with no need for aqueous workup or chromatography. The amidation of N-protected amino acids with both primary and secondary amines proceeds effectively, with very low levels of racemization. B(OCH2CF3)3 can also be used for the formylation of a range of amines in good to excellent yield, via transamidation of dimethylformamide.

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Section: Introductionmentioning

confidence: 99%

Direct Synthesis of Amides from Carboxylic Acids and Amines Using B(OCH₂CF₃)₃

2013

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“…This bond is of great importance because it can be found in a wide variety of molecules both in natural products and in small molecules with pharmacological activity [7][8][9]. Therefore, the development of new direct amidation reactions is important [10,11]. One of those direct methodologies of amide formation is by reacting amines with carboxylic acids using toluene as a solvent [12] or using radiofrequency heating under neat conditions [13].…”

Section: Use Of Carboxylic Acids 21 Organic Synthesismentioning

confidence: 99%

Applications of Carboxylic Acids in Organic Synthesis, Nanotechnology and Polymers

Sáenz‐Galindo¹,

López²,

Duran³

et al. 2018

Carboxylic Acid - Key Role in Life Sciences

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Carboxylic acids are versatile organic compounds. In this chapter is presented a current overview of the use of carboxylic acids in a different area as organic synthesis, nanotechnology, and polymers. The application carboxylic acids in these areas are: obtaining of small molecules, macromolecules, synthetic or natural polymers, modification surface of nanoparticles metallic, modification surface of nanostructure such as carbon nanotubes and graphene, nanomaterials, medical field, pharmacy, etc. Carboxylic acids can be natural and synthetic, can be extracted or synthesized, presented chemical structure highly polar, active in organic reactions, as substitution, elimination, oxidation, coupling, etc. In nanotechnology, the use of acid carboxylic as surface modifiers to promote the dispersion and incorporation of metallic nanoparticles or carbon nanostructure, in the area of polymer carboxylic acids present applications such monomers, additives, catalysts, etc. The purpose of this chapter is to emphasize the importance of carboxylic acids in different areas, highlighting the area of organic synthesis, nanotechnology and polymers and its applications.

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“…Amide bond formation is an important transformation in organic synthesis ,. It is often present in many natural products, pharmaceuticals, agrochemicals, and biological systems .…”

Section: Introductionmentioning

confidence: 99%