Green Biogenic Synthesis of Silver Nanoparticles Using Aqueous Extract of Moringa Oleifera: Access to a Powerful Antimicrobial, Anticancer, Pesticidal and Catalytic Agents

Abdel‐Rahman, Laila H.; Al–Farhan, Badriah Saad; El‐ezz, Doaa Abou; Sayed, Murtaza; Zikry, Mallak Megalea; Abu‐Dief, Ahmed M.

doi:10.1007/s10904-021-02186-9

Cited by 37 publications

(14 citation statements)

References 67 publications

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“…These results suggested that CNCs-1 nanocomposite film have better antibacterial activity against E. coli than others. The poor antibacterial activity of CNCs-2 was due to the aggregation of CNCs, resulting in the agglomeration of CS NPs, showing consistent trends with Figure 1 D and Figure 3 E. Previous studies had reported that NPs with ~100 nm in diameter had more than three-fold greater arterial uptake capacity compared to the particle in larger size (~275 nm) [ 47 , 48 ]. Therefore, developing dispersible CS NPs with smaller particle sizes is critical to improve their antibacterial properties.…”

Section: Resultssupporting

confidence: 80%

Preparation, Characterization and Antibacterial Property Analysis of Cellulose Nanocrystals (CNC) and Chitosan Nanoparticles Fine-Tuned Starch Film

Deng

Tan

et al. 2022

Molecules

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To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents. CNCs with varied concentrations were added to PS and CS NPs composite system to evaluate the optimal film performance. The results showed that tensile strength (TS) of nanocomposite film with 0, 0.01, 0.05, and 0.1% (w/w) CNCs incorporation were 41, 46, 47 and 41 MPa, respectively. The elongation at break (EAB) reached 12.5, 10.2, 7.1 and 13.3%, respectively. Due to the reinforcing effect of CNCs, surface morphology and structural properties of nanocomposite film were altered. TGA analysis confirmed the existence of hydrogen bondings and electrostatic attractions between components in the film-forming matrix. The prepared nanocomposite films showed good antibacterial properties against both E. coli and S. aureus. The nanocomposite film, consist of three most abundant biodegradable polymers, could potentially serve as antibacterial packaging films with strong mechanical properties for food and allied industries.

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Section: Resultssupporting

confidence: 80%

Preparation, Characterization and Antibacterial Property Analysis of Cellulose Nanocrystals (CNC) and Chitosan Nanoparticles Fine-Tuned Starch Film

Deng

Tan

et al. 2022

Molecules

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“…Hawar et al [71] conducted a similar study in which AgNPs showed an SPR at 435 nm, which is a characteristic peak of AgNPs. Likewise, green-synthesized AgNPs from an aqueous extract of Moringa oleifera showed a peak at 440 nm, and our results are in accordance with it [72]. In another study, AgNPs synthesized using leaf extract of Caesalpinia bonducella represented an SPR at 427 nm, indicating the formation of oval and spherical-shaped NPs [73].…”

Section: Synthesis Of J Regia-mediated Agnpssupporting

confidence: 87%

Antifungal Activity of Juglans-regia-Mediated Silver Nanoparticles (AgNPs) against Aspergillus-ochraceus-Induced Toxicity in In Vitro and In Vivo Settings

Naqvi

Kausar

Afzal

et al. 2023

JFB

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Aflatoxins produced by some species of Aspergillus are considered secondary toxic fungal by-products in feeds and food. Over the past few decades, many experts have focused on preventing the production of aflatoxins by Aspergillus ochraceus and also reducing its toxicity. Applications of various nanomaterials in preventing the production of these toxic aflatoxins have received a lot of attention recently. The purpose of this study was to ascertain the protective impact of Juglans-regia-mediated silver nanoparticles (AgNPs) against Aspergillus-ochraceus-induced toxicity by exhibiting strong antifungal activity in in vitro (wheat seeds) and in vivo (Albino rats) settings. For the synthesis of AgNPs, the leaf extract of J. regia enriched with high phenolic (72.68 ± 2.13 mg GAE/g DW) and flavonoid (18.89 ± 0.31 mg QE/g DW) contents was used. Synthesized AgNPs were characterized by various techniques, including TEM, EDX, FT-IR, and XRD, which revealed that the particles were spherical in shape with no agglomeration and fine particle size in the range of 16–20 nm. In vitro antifungal activity of AgNPs was tested on wheat grains by inhibiting the production of toxic aflatoxins by A. ochraceus. According to the results obtained from High-Performance Liquid Chromatography (HPLC) and Thin-Layer Chromatography (TLC) analyses, there was a correlation between the concentration of AgNPs and a decrease in the production of aflatoxin G1, B1, and G2. For in vivo antifungal activity, Albino rats were administrated with different doses of AgNPs in five groups. The results indicated that the feed concentration of 50 µg/kg feed of AgNPs was more effective in improving the disturbed levels of different functional parameters of the liver (alanine transaminase (ALT): 54.0 ± 3.79 U/L and aspartate transaminase (AST): 206 ± 8.69 U/L) and kidney (creatinine 0.49 ± 0.020 U/L and BUN 35.7 ± 1.45 U/L), as well as the lipid profile (LDL 22.3 ± 1.45 U/L and HDL 26.3 ± 2.33 U/L). Furthermore, the histopathological analysis of various organs also revealed that the production of aflatoxins was successfully inhibited by AgNPs. It was concluded that the harmful effects of aflatoxins produced by A. ochraceus can be successfully neutralized by using J. regia-mediated AgNPs.

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“…A study by Dehkordi et al 37 showed that 10 µg/mL AgNPs inhibited the growth of S. aureus by 90%. A study carried out by Abdel-Rahman et al 38 also indicated the antibacterial properties of AgNPs against S. aureus, B. subtilis, S. marcescens, E. coli ; however, used NPs were synthesized with biogenic method using extract of Moringa Oleifera .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antimicrobial, Cytotoxic, and Physical Properties of Selected Nano-Complexes in Bovine Udder Inflammatory Pathogen Control

Wierzbicki,

Kot,

Lange

et al. 2024

NSA

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Purpose Mastitis in dairy cows is a worldwide problem faced by dairy producers. Treatment mainly involves antibiotic therapy, however, due to widespread antibiotic resistance among bacteria, such treatments are no longer effective. For this reason, scientists are searching for new solutions to combat mastitis , which is caused by bacteria, fungi, and algae. One of the most promising solutions, nanotechnology, is attracting research due to its biocidal properties. The purpose of this research was to determine the biocidal properties of nanocomposites as a potential alternative to antibiotics in the control of mastitis , as well as to determine whether the use of nanoparticles and what concentration is safe for the breeder and the animal. Patients and Methods In this study, the effects of Ag, Au, Cu, Fe, and Pt nanoparticles and their complexes were evaluated in relation to the survival of bacteria and fungi isolated from cattle diagnosed with mastitis , their physicochemical properties, and their toxicity to bovine and human mammary epithelial cells BME-UV1 and HMEC (human microvascular endothelial cells). Moreover, E. coli, S. aureus, C. albicans , and Prototheca sp. invasion was assessed using the alginate bead (bioprinted) model. The NPs were tested at concentrations of 25, 12.5, 6.25, 3.125, 1.56 mg/l for Au, Ag, Cu and Fe NPs, and 10, 5, 2.5, 1.25, 0.625 mg/l for Pt. Results With the exception of Fe and Pt, all exhibited biocidal properties against isolates, while the AgCu complex had the best effect. In addition, nanoparticles showed synergistic effects, while the low concentrations had no toxic effect on BME-UV1 and HMEC cells. Conclusion Synergistic effects of nanoparticles and no toxicity to bovine and human cells might, in the future, be an effective alternative in the fight against microorganisms responsible for mastitis , and the implementation of research results in practice would reduce the percentage of dairy cows suffering from mastitis . The problem of increasing antibiotic resistance is posing a global threat to human’s and animal’s health, and requires comprehensive research to evaluate the potential use of nanoparticles – especially their complexes – as well as to determine whether nanoparticles are safe for the breeders and the animals. The conducted series of studies allows further consideration of the use of the obtained results in practice, creating a potentially new alternative to antibiotics in the treatment and prevention of mastitis in dairy cattle.

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Green Biogenic Synthesis of Silver Nanoparticles Using Aqueous Extract of Moringa Oleifera: Access to a Powerful Antimicrobial, Anticancer, Pesticidal and Catalytic Agents

Cited by 37 publications

References 67 publications

Preparation, Characterization and Antibacterial Property Analysis of Cellulose Nanocrystals (CNC) and Chitosan Nanoparticles Fine-Tuned Starch Film

Preparation, Characterization and Antibacterial Property Analysis of Cellulose Nanocrystals (CNC) and Chitosan Nanoparticles Fine-Tuned Starch Film

Antifungal Activity of Juglans-regia-Mediated Silver Nanoparticles (AgNPs) against Aspergillus-ochraceus-Induced Toxicity in In Vitro and In Vivo Settings

Evaluation of the Antimicrobial, Cytotoxic, and Physical Properties of Selected Nano-Complexes in Bovine Udder Inflammatory Pathogen Control

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