Green approach for the synthesis of chalcone (3-(4-fluorophenyl)-1-(4-methoxyphenyl) prop-2-en-1-one) using concentrated solar radiation

Jadhav, Nilesh L.; Pandit, Aniruddha B.; Pinjari, Dipak V.

doi:10.1016/j.solener.2017.03.047

Cited by 23 publications

(15 citation statements)

References 19 publications

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“…The solar radiations include infrared waves that allow the molecules to vibrate and rotate faster. Interestingly, Jadhav group proposed a possible explanation based on the bombardment radiations, giving an increment of energy, that speed up the reaction itself ( Jadhav et al, 2017 ).…”

Section: Green Enabling Technologies Applied To the Synthesis And Der...mentioning

confidence: 99%

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

Marotta

Rossi²,

Ibba³

et al. 2022

Front. Chem.

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The sustainable use of resources is essential in all production areas, including pharmaceuticals. However, the aspect of sustainability needs to be taken into consideration not only in the production phase, but during the whole medicinal chemistry drug discovery trajectory. The continuous progress in the fields of green chemistry and the use of artificial intelligence are contributing to the speed and effectiveness of a more sustainable drug discovery pipeline. In this light, here we review the most recent sustainable and green synthetic approaches used for the preparation and derivatization of chalcones, an important class of privileged structures and building blocks used for the preparation of new biologically active compounds with a broad spectrum of potential therapeutic applications. The literature here reported has been retrieved from the SciFinder database using the term “chalcone” as a keyword and filtering the results applying the concept: “green chemistry”, and from the Reaxys database using the keywords “chalcone” and “green”. For both databases the time-frame was 2017–2022. References were manually selected based on relevance.

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Section: Green Enabling Technologies Applied To the Synthesis And Der...mentioning

confidence: 99%

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

Marotta

Rossi²,

Ibba³

et al. 2022

Front. Chem.

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“…Previous research studies suggest that various chemical transformations have been reported using CSR such as synthesis of chalcones, benzylic bromination, oxidation of alcohol, synthesis of DES and N‐Phenyl phthalimide, N‐acylation and N‐formylation reactions in aqueous medium, etc. Thus, CSR is witnessing a scientific revolution in field of chemistry that urges us to find its newer applications in organic synthesis.…”

Section: Figurementioning

confidence: 99%

“…This is a possible reason for the increase in the rate of a chemical reaction. CSR carries UV‐Visible radiations along with Infra‐red radiations which may give synergetic effect for faster reaction …”

Section: Figurementioning

confidence: 99%

“…The energy used for the synthesis of 3‐methyl‐4‐arylmethylene‐isoxazole‐5(4H)‐one is the total energy consumed (kJ) per unit of the 3‐methyl‐4‐arylmethylene‐isoxazole‐5(4H)‐one obtained (g). The reaction time to synthesize 3‐methyl‐4‐arylmethylene‐isoxazole‐5(4H)‐one was 8 hours using a conventional method, while 3 min for the CSR technique . The amount of energy needed to produce 3‐methyl‐4arylmethylene‐isoxazole‐5(4H)‐one per gram is 6.98 (kJ)/g, and 0.89 (kJ)/g for conventional and CSR method respectively.…”

Section: Figurementioning

confidence: 99%

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Concentrated Solar Radiation Aided Green Approach for Preparative Scale and Solvent‐Free Synthesis of 3‐Methyl‐4‐(hetero)arylmethylene Isoxazole‐5(4H)‐ones

Gadkari

Jadhav

Hatvate³

et al. 2020

ChemistrySelect

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An efficient, clean, and environmentally benign approach for the synthesis of 3-methyl-4-arylmethylene isoxazole-5(4H)-ones has been developed using concentrated solar radiations (CSR). One pot, multicomponent synthesis from aromatic / heteroaromatic aldehydes, ethyl acetoacetate and hydroxylamine hydrochloride leads to title compounds in high yields. Notably the reaction has been carried out in under solvent and catalystfree conditions within a very short time (3 min). Further, the reaction was scaled up to 50 mmol. The present method is also energy efficient and saves almost more than 87 % of energy as compared to the conventional method.

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“…[20][21][22][23] The need of the hour is to develop the methodologies that can effectively harness the solar energy. Concentrated solar radiation (CSR) has been proved to be very effective in a very few recent reports [24][25] because of focused beam and easy handling that provided higher yield in short duration of time.…”

Section: Introductionmentioning

confidence: 99%

Concentrated solar radiation promoted unconventional greener approach: solvent-free benign synthesis of functionalized benzimidazoles

Harsh¹,

Yusuf²,

Sharma³

et al. 2018

Arkivoc

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Renewable concentrated solar-radiation (CSR) offered a promising en route for the development of practical, highly efficient, scalable, catalyst free and solvent-free clean process leading to the synthesis of functionalized benzimidazoles. Developed protocol has a very good substrate scope, involves mild reaction conditions and products obtained in good to excellent yields. Method presented the observations in which light alone could affect the remarkable changes with more than 85% energy saving and 75% less reaction time in listed organic transformations.

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Green approach for the synthesis of chalcone (3-(4-fluorophenyl)-1-(4-methoxyphenyl) prop-2-en-1-one) using concentrated solar radiation

Cited by 23 publications

References 19 publications

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

Concentrated Solar Radiation Aided Green Approach for Preparative Scale and Solvent‐Free Synthesis of 3‐Methyl‐4‐(hetero)arylmethylene Isoxazole‐5(4H)‐ones

Concentrated solar radiation promoted unconventional greener approach: solvent-free benign synthesis of functionalized benzimidazoles

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