Green and Synthetic Metallic Nanoparticles - Obtaining, Characterization and Biological Evaluation in Association with Lupeol

Abstract

The field of metal nanotechnology continues to draw the attention of researchers from different areas due to the outstanding properties of nanoparticles. The main aims of this research were to obtain and to study two types of gold nanoparticles; different obtaining pathways (the chemical synthesis and the biosynthesis based on an aqueous extract of lemon balm) were involved in this research. The chemically synthesized nanoparticles were loaded with lupeol. After a preliminary physico-chemical characterization, the compounds obtained were tested in order to evaluate the effects on the viability of colon cancer cells. The formulation of these new gold nanoparticles with average size between 38 and 82 nm, with a good stability against the tendency to form agglomerations according to the Zeta potential values, was confirmed by UV-Vis spectra; the particles containing lupeol have show the best activity against the colon cancer cells.

A Triterpenoid Lupeol as an Antioxidant and Anti-Neuroinflammatory Agent: Impacts on Oxidative Stress in Alzheimer’s Disease

“…Despite the limited therapeutic uses of Lupeol because of some basic limitations, including its low solubility, bioavailability and drug delivery, which were reported in [111], numerous novel advances of targeted drug transfer and advanced techniques were also introduced regarding this compound, such as Lupeol-loaded PEGylated [111], NF-kB-PLGA nanoparticles that were loaded with Lupeol [109], Lupeol-entangled chitosangelatin hydrogel films [112], gold nanoparticles [113], and solid-lipid nanoparticles (SLNs) [108]. Briefly, the latest remedies are expected to develop novel methods by which all the designed parameters of Lupeol can be boosted, including solubility, cell proliferation and its effectiveness against neurodegeneration, especially AD.…”