Abstract:New generations of biorefinery combine innovative biomass waste resources from different origins, chemical extraction and/or synthesis of biomaterials, biofuels, and bioenergy via green and sustainable processes. From the very beginning, identifying and evaluating all potentially high value-added chemicals that could be removed from available renewable feedstocks requires robust, efficient, selective, reproducible, and benign analytical approaches. With this in mind, green and sustainable separation of natural… Show more
“…On the other hand, food production side-streams have now been greatly acknowledged as key bioresources of value-added substances with high prospects in food, cosmetics, chemical, and pharmaceutical industry. Thus, separation processes that are based on eco-friendly technologies for the recovery of bioactive natural products from agro-industrial waste is particularly attractive, while taking both socio-environmental and economic aspects into account [2].…”
Olive leaves (OLL) are considered to be a highly appreciated bioresource of bioactive polyphenolic phytochemicals, embracing several different structures. However, extraction processes based on deep eutectic solvents (DES) are very limited despite the wide range of techniques developed for the efficient recovery of polyphenols. This study had as objective the development of a simple, green, high-performance extraction methodology for OLL polyphenols, using a recently reported effective DES, composed of L-lactic acid and glycine. Initially, a screening was performed to select the most appropriate L-lactic/glycine molar ratio and process optimization was then carried out with response surface methodology. The optimized process variable values were DES/water (78% w/v), liquid-to-solid ratio of 36 mL g−1, and stirring speed of 500 rounds per minute, and the total polyphenol yield amounted to 97.53 ± 3.54 mg gallic acid equivalents per g dry matter. Extraction with DES at 80 °C did not significantly increase the total polyphenol yield, but it did enhance the total flavonoid yield and antioxidant activity. High-performance liquid chromatography analyses revealed that extraction with the DES resulted in extended oleuropein hydrolysis, to the favor of hydroxytyrosol formation. This finding might have a prospect in using properly tuned DES for polyphenol modification with improved bioactivities.
“…On the other hand, food production side-streams have now been greatly acknowledged as key bioresources of value-added substances with high prospects in food, cosmetics, chemical, and pharmaceutical industry. Thus, separation processes that are based on eco-friendly technologies for the recovery of bioactive natural products from agro-industrial waste is particularly attractive, while taking both socio-environmental and economic aspects into account [2].…”
Olive leaves (OLL) are considered to be a highly appreciated bioresource of bioactive polyphenolic phytochemicals, embracing several different structures. However, extraction processes based on deep eutectic solvents (DES) are very limited despite the wide range of techniques developed for the efficient recovery of polyphenols. This study had as objective the development of a simple, green, high-performance extraction methodology for OLL polyphenols, using a recently reported effective DES, composed of L-lactic acid and glycine. Initially, a screening was performed to select the most appropriate L-lactic/glycine molar ratio and process optimization was then carried out with response surface methodology. The optimized process variable values were DES/water (78% w/v), liquid-to-solid ratio of 36 mL g−1, and stirring speed of 500 rounds per minute, and the total polyphenol yield amounted to 97.53 ± 3.54 mg gallic acid equivalents per g dry matter. Extraction with DES at 80 °C did not significantly increase the total polyphenol yield, but it did enhance the total flavonoid yield and antioxidant activity. High-performance liquid chromatography analyses revealed that extraction with the DES resulted in extended oleuropein hydrolysis, to the favor of hydroxytyrosol formation. This finding might have a prospect in using properly tuned DES for polyphenol modification with improved bioactivities.
Much has been done in the wine production sector to promote sustainable development. Given its relevance in the economy and in society, it is fundamental to align its activities with the optimal use of resources and the regeneration and restoration of the natural system in agreement with the premises set by the Circular Economy (CE). The main interest of this work was, through a systematic literature review, to identify in the revised studies how the wine sector has incorporated the premises of CE in its activities. Six topics define the concerns addressed: water, solid waste, energy, chemical use, land use and ecosystems, in different parts of the chain: viticulture, winemaking and distribution. From the evaluation of 41 selected empirical studies, no clear definition regarding CE was found; however, the detailed analysis reveals aspects which incorporate CE practices such as the reduction of waste disposal by its treatment and recovery, the best use of resources at all stages of the process chain and the need to rethink and redesign current practices. The specific subjects identified were waste recovery, alternative energy sources such as biofuels production and water quality improvement. Land use, ecosystem impacts, and use of agrochemicals were not considered.
“…Besides rich in flavonoids [19], they are odorless and can be stored for a long time after the harvesting. The utilization of a biomass endowed with these positive peculiarities fulfills the principles of circular economy and meets the need of environmentally aware consumers [20].…”
The onion non-edible outside layers represent a widely available waste material deriving from its processing and consumption. As onion is a vegetable showing many beneficial properties for human health, a study aiming to evaluate the use of extract deriving from the non-edible outside layers was planned. An eco-friendly extraction method was optimized using a hydroalcoholic solution as solvent. The obtained extract was deeply characterized by in vitro methods and then formulated in autoadhesive, biocompatible and pain-free hydrogel polymeric films. The extract, very soluble in water, showed antioxidant, radical scavenging, antibacterial and anti-inflammatory activities, suggesting a potential dermal application for wounds treatment. In vitro studies showed a sustained release of the extract from the hydrogel polymeric film suitable to reach concentrations necessary for both antibacterial and anti-inflammatory activities. Test performed on human keratinocytes showed that the formulation is safe suggesting that the projected formulation could be a valuable tool for wound treatment.
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