Bioadhesive Polymeric Films Based on Red Onion Skins Extract for Wound Treatment: An Innovative and Eco-Friendly Formulation

Pagano, Cinzia; Marinozzi, Maura; Baiocchi, Claudio; Beccari, Tommaso; Calarco, Paola; Ceccarini, Maria Rachele; Chielli, Michela; Orabona, Ciriana; Orecchini, Elena; Ortenzi, Roberta; Ricci, Maurizio; Scuota, Stefania; Tiralti, Maria Cristina; Perioli, Luana

doi:10.3390/molecules25020318

Cited by 32 publications

(21 citation statements)

References 43 publications

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“…After preliminary studies based on the evaluation of hydrogels characteristics (homogeneity and consistency), easy of casting and final film appearance (imperfection detected by visual inspection), the most suitable compositions of the starting hydrogels used to prepare the films were the follows: hydrogel-AL: AL 1.5% (wt/wt), glycerol 10% (wt/wt), bidistilled water until 100 g; hydrogel-XG: XG 1% (wt/wt), glycerol 10% (wt/wt), bidistilled water until 100 g. Glycerol was chosen as plasticizing agent as observed in other studies [ 17 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

Development and Characterization of Xanthan Gum and Alginate Based Bioadhesive Film for Pycnogenol Topical Use in Wound Treatment

et al. 2021

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Pycnogenol (PYC) is a concentrate of phenolic compounds derived from French maritime pine; its biological activity as antioxidant, anti-inflammatory and antibacterial suggests its use in the treatment of open wounds. A bioadhesive film, loaded with PYC, was prepared by casting, starting with a combination of two biopolymer acqueous solutions: xanthan gum (1% wt/wt) and sodium alginate (1.5% wt/wt), in a 2.5/7.5 (wt/wt) ratio. In both solutions, glycerol (10% wt/wt) was added as plasticizing agent. The film resulted in an adhesive capable to absorb a simulated wound fluid (~65% wt/wt within 1 h), therefore suitable for exuding wounds. The mechanical characterization showed that the film is deformable (elastic modulus E = 3.070 ± 0.044 MPa), suggesting adaptability to any type of surface and resistance to mechanical solicitations. PYC is released within 24 h by a sustained mechanism, achieving a maximum concentration of ~ 0.2 mg/mL, that is safe for keratinocytes, as shown by cytotoxicity studies. A concentration of 0.015 mg/mL is reached in the first 5 min after application, at which point PYC stimulates keratinocyte growth. These preliminary results suggest the use of PYC in formulations designed for topical use.

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Section: Resultsmentioning

confidence: 99%

Development and Characterization of Xanthan Gum and Alginate Based Bioadhesive Film for Pycnogenol Topical Use in Wound Treatment

et al. 2021

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“…The release of pro-inflammatory cytokines, IL-6, TNF-α and IL-1β in the same cell system was analyzed as reported in the literature [ 11 ]. Specifically, IL-6 secretion by LPS-treated RAW 264.7 macrophages was significantly inhibited by D.E.…”

Section: Resultsmentioning

confidence: 99%

“…The dry extract (D.E.) was prepared by a method already used with success for other vegetal matrices [ 11 , 12 ] and properly adapted for this matrix. Flaxseed flour (2 g) was suspended in 80 mL of a hydroalcoholic solution (EtOH/water 60:40 v / v ) and kept at 45 °C under magnetic stirring (800 rpm) for 90 min, the obtained suspension was then centrifuged (4000 rpm, 10 min, R.T.).…”

Section: Methodsmentioning

confidence: 99%

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Emulgel Loaded with Flaxseed Extracts as New Therapeutic Approach in Wound Treatment

et al. 2021

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Dry (D.E.) and liquid (L.E.) extracts were prepared from flaxseeds and their application in health field was evaluated. The chemical analysis showed that D.E. is rich in the lignan secoisolariciresinol diglucoside and L.E. in unsaturated triglycerides containing linolenic acid. Mainly, D.E. showed reducing (15.73 μmol Fe2+/g) and radical scavenging capacities (5.25 mg TE/g) and ability to down-regulate the expression of the pro-inflammatory cytokines NO (IC50 = 0.136 ± 0.009 mg/mL) and IL-6 (IC50 = 0.308 ± 0.103 mg/mL), suggesting its use in wound treatment. D.E. and L.E. were active against S. pyogenes and D.E. also against S. aureus. The two extracts were combined in a novel O/W emulgel in which the water phase was viscosized using a low molecular weight and highly deacetylated chitosan (1% wt./v). The presence of this polymer in the emulgel decreased the MIC values of the extracts. In fact, MIC shifted from 0.59 mg/mL to 0.052 mg/mL for D.E. and from 0.22 mg/mL to 0.036 mg/mL for L.E., concentrations safe both for keratinocytes and macrophages. Moreover, the emulgel demonstrated to inhibit S. aureus, P. aeruginosa, S. pyogenes, E. coli, and K. pneumoniae growth (inhibition halos 24–36 mm), strains often responsible for diabetic foot ulcer infection.

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“…(A) Maceration (MAC), (B) Ultrasonic Bath (UB), (C) High-Power Ultrasonic (HPU). Maceration is the classical method already used with success for other vegetal matrices [13][14][15] and for this reason chosen for comparison.…”

Section: Extracts Preparationmentioning

confidence: 99%

Hazelnut Shells as Source of Active Ingredients: Extracts Preparation and Characterization

et al. 2021

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Hazelnut shells represent a waste material (about 42% of the total biomass) deriving from hazelnut harvest. These are mainly used as a heating source; however, they represent an interesting source of polyphenols useful in health field. The impact on phenolic profile and concentrations of hazelnut shell extracts obtained by three extraction methods (maceration, ultrasonic bath, and high-power ultrasonic), as well as temperature, extraction time, and preventive maceration, was studied. The prepared extracts were characterized in terms of chemical composition, antioxidant and antimicrobial activities. Eighteen different phenolic compounds were identified and quantified by chemical analysis and gallic acid was the most abundant in all the extracts analyzed. Other relevant compounds were chlorogenic acid, protocatechuic acid and catechin. Preventive maceration had a positive effect on the extraction of different types of compounds regardless of the method performed. Application of the high-power ultrasonic method had different effects, either positive or negative, depending on the type of compound and extraction time. All the prepared extracts showed antioxidant activity especially those prepared by maceration, and many of them were able to inhibit the growth of both B. subtilis and B. cereus.

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Bioadhesive Polymeric Films Based on Red Onion Skins Extract for Wound Treatment: An Innovative and Eco-Friendly Formulation

Cited by 32 publications

References 43 publications

Development and Characterization of Xanthan Gum and Alginate Based Bioadhesive Film for Pycnogenol Topical Use in Wound Treatment

Development and Characterization of Xanthan Gum and Alginate Based Bioadhesive Film for Pycnogenol Topical Use in Wound Treatment

Emulgel Loaded with Flaxseed Extracts as New Therapeutic Approach in Wound Treatment

Hazelnut Shells as Source of Active Ingredients: Extracts Preparation and Characterization

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