Greater coronary lipid core plaque assessed by near-infrared spectroscopy intravascular ultrasound in patients with elevated xanthine oxidoreductase: a mechanistic insight

Uric acid and cardiovascular disease: A clinical review

“…Beyond the level of serum uric acid, we also recently showed a significant relation of XOR to coronary lipid plaques evaluated by near-infrared spectroscopy in patients with chronic coronary syndrome [58] . Of note, however, no relations between XOR activity and systemic inflammation or endothelial function was found, suggesting that there might be other mechanisms in the development of coronary atherosclerosis with uric acid and XOR beyond endothelial dysfunction and inflammatory reaction [59] . In addition to epicardial obstructive CAD, serum uric acid is reportedly associated with inflammation and endothelial function in patients with non-obstructive CAD (e.g.…”

Association of plasma xanthine oxidoreductase activity with vascular endothelial function independent of serum uric acid level: MedCity21 health examination registry

“…Saito et al presented unexpected results based on RH-peripheral arterial tonometry (RH-PAT) that demonstrated no significant association of plasma XOR activity with reactive hyperemia index (RHI) in patients with stable coronary artery disease [38] . Although both FMD and RH-PAT are established methods for assessing VEF, FMD reflects endothelial function in large conduit arteries (macrovascular), while RHI reflects that in resistance arteries (microvascular) [23] , [39] .…”

Impact of Serum Uric Acid Level on Systemic Endothelial Dysfunction in Patients with a Broad Spectrum of Ischemic Heart Disease

“…After excluding 18 patients who received antihyperuricemic agents, 52 were included in the present analysis (CCS-CABG group). Another CCS cohort included 68 patients undergoing elective PCI procedures under intravascular ultrasound guidance (UMIN000027855) (CCS-PCI group) [ 11 , 12 ]. Patients with ACS ( n = 46) were also included in the present pooled data from a retrospective study (ACS group) [ 6 ].…”

“…Systemic endothelial function was assessed with reactive hyperemic index (RHI) using the EndoPAT 2000 device (Itamar Medical Inc., Caesarea, Israel), which is validated to evaluate endothelial function non-invasively, operator-independently, and reproducibly [ 22 ]. RHI was measured as previously described [ 6 , 8 , 9 , 10 , 11 , 12 , 19 ]. Briefly, patients fasted and refrained from taking caffeine, tobacco, and all medications for at least eight hours.…”