Great Saphenous Vein Leiomyosarcoma: A Rare Malignant Tumor of the Extremity—Two Case Reports

Minh, Thuc Le; D, Cazaban; Michaud, Jean; Ginestet-Auge, Marie Christine; Laporte, Marie Hélène; Patelli, Annie; Marre, A.

doi:10.1007/s10016-003-0090-2

Cited by 20 publications

(21 citation statements)

References 7 publications

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“…They may originate from smooth muscles of the venous wall like leiomyosarcomas and leiomyomas or from endothelial cells like hemangioendotheliomas [1,2]. Smooth muscle tumours tend to appear in the central parts of the body and their presence in peripheral vessels is certain rarity.…”

Section: Discussionmentioning

confidence: 99%

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Rare presentation of a benign smooth muscle tumour of venous wall

Brzeziński¹,

Osęka²,

Skórski³

2017

Acta Angiologica

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Section: Discussionmentioning

confidence: 99%

“…CT scan and MRI are thought to be gold standard for diagnosis of soft tissue tumours and venous tumours as well. MRI seems to be more effective although both techniques provide visualization of the tumour and confirm its venous origin [2][3][4].…”

Section: Discussionmentioning

confidence: 99%

Rare presentation of a benign smooth muscle tumour of venous wall

Brzeziński¹,

Osęka²,

Skórski³

2017

Acta Angiologica

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“…Vascular leiomyosarcoma is a rare mesenchymal tumour arising from smooth muscle cells, and it is the most frequent type of primary malignant vascular tumour2 making up <2% of all leiomyosarcomas in which veins are involved five times more often than arteries:3 most commonly the inferior vena cava followed by renal vein, femoral vein and great saphenous vein. With reference to the literature, the vascular leiomyosarcoma of extremities has been reported in cephalic vein, femoral vein, superficial femoral vein, popliteal vein, great saphenous vein and dorsal vein of the foot.…”

Section: Discussionmentioning

confidence: 99%

Leiomyosarcoma of great saphenous vein localised to the calf

et al. 2016

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We present the case of a 76-year-old man with a 2-month history of mildly tender swelling in the right calf for which he had an initial excision and then a wide local excision followed by a split skin graft because the initial histopathology confirmed that there was a Grade I leiomyosarcoma of great saphenous vein. A simple lump in the lower limb could be a malignant vascular tumour and should always be considered in the list of differential diagnosis of a lump in the lower limb.

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“…In contrast, vascular LMSs are associated with large‐caliber vessels and harbor worse prognosis. The great saphenous vein (GSV) corresponds to the main superficial large‐caliber vessel affected by LMS with a few more than 30 cases published so far in English literature . Other superficial large vessels rarely reported to harbor LMS include short saphenous vein and cephalic vein …”

Section: Introductionmentioning

confidence: 99%

Leiomyosarcoma of the great saphenous vein (vena saphena magna) with granular cell change: Report of a superficial neoplasm

et al. 2017

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The great saphenous vein (GSV) corresponds to the main superficial large-caliber vessel affected by leiomyosarcoma (LMS). Given its superficial location and because signs of vascular origin may not be clinically apparent, LMS of the GSV may be misinterpreted clinically as superficial nonvascular soft tissue mass. Herein, we report a case on the distal portion of the right GSV of a 57-year-old man. The histopathological recognition of a large-caliber vein-associated LMS (with granular cell change) in an incisional biopsy specimen was crucial to guide radiological evaluation and confirmation of a superficial vascular LMS before surgical treatment. Recognizing this entity in small biopsies is important as its surgical treatment and prognosis differ substantially from nonvascular superficial (ie, subcutaneous and dermal) LMSs. In addition, because vascular LMSs can involve long vessel segments, underestimation of extent of disease is a risk. To the best of our knowledge, granular cell change has not been documented in LMS of the GSV.

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Great Saphenous Vein Leiomyosarcoma: A Rare Malignant Tumor of the Extremity—Two Case Reports

Cited by 20 publications

References 7 publications

Rare presentation of a benign smooth muscle tumour of venous wall

Rare presentation of a benign smooth muscle tumour of venous wall

Leiomyosarcoma of great saphenous vein localised to the calf

Leiomyosarcoma of the great saphenous vein (vena saphena magna) with granular cell change: Report of a superficial neoplasm

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