Grazing-Angle Fiber-Optic Fourier Transform Infrared Reflection−Absorption Spectroscopy for the in Situ Detection and Quantification of Two Active Pharmaceutical Ingredients on Glass

Abstract

Fourier transform infrared reflection-absorption spectroscopy has been used with a fiber-optic grazing-angle reflectance probe as a rapid, in situ method for trace surface analysis of acetaminophen and aspirin at loadings of approximately 0-2 microg cm(-2) on glass. Partial least-squares multivariate regression permits the loadings to be quantified, simultaneously, with root-mean-squared errors of prediction of RMSEP approximately 0.1 microg cm(-2) for both compounds. The detection limits are estimated to be LD approximately 0.2 microg cm(-2).

Preparation of TNT, RDX and Ammonium Nitrate Standards on Gold-on-Silicon Surfaces by Thermal Inkjet Technology

“…Samples and standards of nitrocompounds [7,9] and cyclic organic peroxides [24] as well as pharmaceutically active ingredients and excipients [25,26] have been prepared. These studies centered on covering relatively large surface areas (*43 cm 2 ) on stainless steel, aluminum or glass.…”

Detecting bacteria contamination on medical device surfaces using an integrated fiber-optic mid-infrared spectroscopy sensing method

“…4. However, spectra from a non-reflective surface (transparent surface) such as transparent polyvinyl or clear glass (data not shown) are distorted and high absorption effects are observed in the spectral range lower than 1500 cm −1 in comparison with reflective or partially-reflective surfaces [23,[33][34][35]. At wavenumber greater than ∼1500 cm −1 non-reflective surface material are transparent to IR radiation.…”

On‐Line PAT Applications of Spectroscopy in the Pharmaceutical Industry

“…In all they have applied this technique to detect and quantitate contaminants on glass, aluminum and stainless steel surfaces. 136,137 Hellings and Vanbaelen used an on -line UV analyzer during the cleaning process of a fully automatic chromatographic system to quantitate the amount of residual product, but also used this analyzer in combination with process data to optimize the cleaning process. 138 …”