Spatial interaction involves a wide range of flows between nodes: these include human movements (e.g., migration, commuting) and movement of materials (e.g., international trade). These flows are important aspects of urban and regional dynamics. At the regional level, interactions include many modes and types of flow, such as rail, air, highways, and even pipelines. In cities, spatial interaction takes a wide variety of forms and includes commuting to work and travel for shopping and other purposes. This article presents a brief guide to some of the more important aspects of the discoveries and applications in this field. Practical areas include aggregate and disaggregate models for flows.