Graves’ Disease Presented as Painful Goiter

Chao, Chen-Shun; Lin, Shih‐Yi; Sheu, Wayne Huey‐Herng

doi:10.1159/000057948

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…Tenderness of gland and pain are a common feature of sub-acute thyroiditis. It is characterized by elevated levels of inflammatory markers i.e., ESR and CRP [ 5 ]. The initial presentation with thyroid pain and tenderness in our case suggested sub-acute thyroiditis; the normal ESR and CRP refuted that diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Graves' Disease Presenting as Painful Goiter: A Case Report and Review of the Literature

Shahbaz¹,

Aziz²,

Umair³

et al. 2018

Cureus

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A painful and tender thyroid gland is a rare phenomenon in Graves' disease. We present a case of 31-years-old Guyanese female who was admitted to the hospital with complaints of neck pain for the past few days. She also reported increase appetite for a few weeks; she did not have palpitations, heat intolerance, or muscle weakness. The presence of hyperthyroidism with elevated TSI suggested that the patient had Graves' disease. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were within normal limit, thus the diagnosis of thyroiditis was effectively ruled out. This is a rare case of a painful and tender thyroid gland in Graves' disease without the evidence of sub-acute thyroiditis.

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Section: Discussionmentioning

confidence: 99%

Graves' Disease Presenting as Painful Goiter: A Case Report and Review of the Literature

Shahbaz¹,

Aziz²,

Umair³

et al. 2018

Cureus

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“…Here we report a rare case of Graves' disease presenting in the postpartum period as SAT. In the literature, only two reports are available of the simultaneous presentation of SAT and Graves' disease but none in postpartum patients [1,2].…”

Section: Discussionmentioning

confidence: 99%

Painful Goiter: A Rare Presentation of Graves’ Disease

Kannan

2014

J Med Cases

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Here we report a rare case of Graves' disease presenting as subacute thyroiditis. In the literature, only two reports are available of such a presentation. Various authors have reported in total 33 patients with subacute thyroiditis who were subsequently, between 1 and 18 months later, diagnosed with Graves' disease. However, only two patients with both subacute thyroiditis and Graves' disease simultaneously have been reported. Subacute thyroiditis is an inflammatory disorder while Graves' disease has an autoimmune basis. Although the association of the two could be incidental, it could be postulated that thyroiditis exposes autoantigens, enhancing antibody formation in susceptible patients and thereby precipitating or unmasking Graves' disease. Hence, it is important to remember that though rare, Graves' disease can present with painful goiter due to concurrent thyroiditis, or rather is unmasked by the inflammation.

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“…However, it was not his primary complaint, and neck pain has also been reported with Graves' disease. 22,23 Further, he did not have elevations of inflammatory markers such as CRP and ESR generally associated with SAT. SARS-CoV-2 has been associated with other thyroid disease.…”

Section: Case Reportmentioning

confidence: 97%

A case report of Graves’ disease following SARS-CoV-2 infection

Rockett

Nelson

Pierce

et al. 2021

Int J Contemp Pediatr

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SARS-CoV-2 pandemic has had significant impacts on the world. The longer the pandemic continues the more we learn about the virus behind it and the post-infection complications. SARS-CoV-2 infections have been associated with immune dysfunction and thyroid disease. The spectrum of thyroid disease reported spans from subacute thyroiditis to Hashimoto’s thyroiditis. We report a 16-years-old patient whose COVID-19 infection was followed by multiple complications including the appearance of symptomatic Graves’ disease. Laboratory analysis was significant for elevated TSH, low free thyroxine, and antibodies consistent with the diagnosis of Graves’ disease. This is the first case of Graves’ disease after COVID-19 infection to be reported and the first case of thyroid dysfunction secondary to COVID-19 infection reported in the pediatric population. The spectrum of thyroid and autoimmune disease following COVID-19 is discussed. Further research into the underlying pathology behind COVID-19 infection and immune dysfunction will lead to expediated diagnosis and improved patient outcomes.

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Graves’ Disease Presented as Painful Goiter

Cited by 7 publications

References 17 publications

Graves' Disease Presenting as Painful Goiter: A Case Report and Review of the Literature

Graves' Disease Presenting as Painful Goiter: A Case Report and Review of the Literature

Painful Goiter: A Rare Presentation of Graves’ Disease

A case report of Graves’ disease following SARS-CoV-2 infection

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