Graves' Disease Presenting as Painful Goiter: A Case Report and Review of the Literature

Shahbaz, Amir; Aziz, Kashif; Umair, Muhammad; Sharifzadeh, Mohaddeseh; Sachmechi, Issac

doi:10.7759/cureus.2765

Cited by 3 publications

(3 citation statements)

References 14 publications

(14 reference statements)

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“…Medical history, clinical findings, biopsy, and histological exam of amyloid lesions are all key components of determining the underlying cause of macroglossia and best treatment plan. While this condition leads to both functional and cosmetic problems for patients, there are no formal guidelines for the treatment of macroglossia secondary to amyloidosis [18,19]. In this case, a partial glossectomy was performed and tissue was submitted to confirm the macroglossia was a complication of amyloidosis associated with multiple myeloma.…”

Section: Discussionmentioning

confidence: 97%

Partial Glossectomy for Treatment of Macroglossia Secondary to Myeloma-Associated Amyloidosis: A Case Report

Jenzer

2021

SJO

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Around 10-15% of patients with multiple myeloma develop amyloidosis due to the extracellular deposition of light-chain amyloid molecules. When this deposition occurs in the tongue, patients may exhibit macroglossia. The sequelae of this macroglossia can include dysphagia and gagging, tooth displacement, and airway compromise. This article presents the case of a 43-year-old African American female who was treated with a partial glossectomy secondary to amyloidosis related multiple myeloma.

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Section: Discussionmentioning

confidence: 97%

Partial Glossectomy for Treatment of Macroglossia Secondary to Myeloma-Associated Amyloidosis: A Case Report

Jenzer

2021

SJO

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“…However, it was not his primary complaint, and neck pain has also been reported with Graves' disease. 22,23 Further, he did not have elevations of inflammatory markers such as CRP and ESR generally associated with SAT. SARS-CoV-2 has been associated with other thyroid disease.…”

Section: Case Reportmentioning

confidence: 96%

A case report of Graves’ disease following SARS-CoV-2 infection

Rockett

Nelson

Pierce

et al. 2021

Int J Contemp Pediatr

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SARS-CoV-2 pandemic has had significant impacts on the world. The longer the pandemic continues the more we learn about the virus behind it and the post-infection complications. SARS-CoV-2 infections have been associated with immune dysfunction and thyroid disease. The spectrum of thyroid disease reported spans from subacute thyroiditis to Hashimoto’s thyroiditis. We report a 16-years-old patient whose COVID-19 infection was followed by multiple complications including the appearance of symptomatic Graves’ disease. Laboratory analysis was significant for elevated TSH, low free thyroxine, and antibodies consistent with the diagnosis of Graves’ disease. This is the first case of Graves’ disease after COVID-19 infection to be reported and the first case of thyroid dysfunction secondary to COVID-19 infection reported in the pediatric population. The spectrum of thyroid and autoimmune disease following COVID-19 is discussed. Further research into the underlying pathology behind COVID-19 infection and immune dysfunction will lead to expediated diagnosis and improved patient outcomes.

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“…During common thyroid disorders (hyper- and hypothyroidism) the activity level of TPO is changed. Thyroiditis is the inflammation of the thyroid gland due to the numerous etiologies [3]. Graves’ disease accounts for 50–80% of cases of hyperthyroidism.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Action and Interactions between Thyroid Peroxidase and Lipoxygenase Inhibitors Derived from Plant Sources

2019

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This study focused on the effect of kaempferol, catechin, apigenin, sinapinic acid, and extracts from plants (i.e., parsley, cumin, mustard, green tea, and green coffee) on thyroid peroxidase (TPO) and lipoxygenase (LOX) activity, antiradical potential, as well as the result of interactions among them. Catechin, sinapinic acid, and kaempferol acted as a competitive TPO inhibitors, while apigenin demonstrated an uncompetitive mode of inhibitory action. Ethanol extracts from all plants acted as competitive TPO inhibitors, while, after in vitro digestion, TPO activation was found especially in the case of mustard (24%) and cumin (19.85%). Most importantly, TPO activators acted synergistically. The TPO effectors acted as LOX inhibitors. The most effective were potentially bioaccessible compounds from green tea and green coffee (IC50 = 29.73 mg DW/mL and 30.43 mg DW/mL, respectively). The highest free radical scavenging ability was determined for catechin and sinapinic acid (IC50 = 78.37 µg/mL and 84.33 µg/mL, respectively) and potentially bioaccessible compounds from mustard (0.42 mg DW/mL) and green coffee (0.87 mg DW/mL). Green coffee, green tea, cumin, and mustard contain potentially bioaccessible TPO activators that also act as effective LOX inhibitors, which indicate their potentially health-promoting effects for people suffering from Hashimoto’s disease.

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Graves' Disease Presenting as Painful Goiter: A Case Report and Review of the Literature

Cited by 3 publications

References 14 publications

Partial Glossectomy for Treatment of Macroglossia Secondary to Myeloma-Associated Amyloidosis: A Case Report

Partial Glossectomy for Treatment of Macroglossia Secondary to Myeloma-Associated Amyloidosis: A Case Report

A case report of Graves’ disease following SARS-CoV-2 infection

Mechanism of Action and Interactions between Thyroid Peroxidase and Lipoxygenase Inhibitors Derived from Plant Sources

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