Graphite nanopowder incorporated xanthan gum scaffold for effective bone tissue regeneration purposes with improved biomineralization

Singh, Asmita; Muduli, Chinmayee; Senanayak, Satyaprasad P.; Goswami, Luna

doi:10.1016/j.ijbiomac.2023.123724

Cited by 8 publications

(4 citation statements)

References 73 publications

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“…This trend was verified by the quantitative analysis of ALP activity, and the CMPC group displayed the highest OD values (Figure 4B). Biomineralization is another critical index for evaluating osteogenesis in later stages [37]. After co-culturing for 21 days, calcium deposition-related assays were performed.…”

Section: Effect Of Cs Coating On In Vitro Osteogenesismentioning

confidence: 99%

Functionalized Magnesium Phosphate Cement Induces In Situ Vascularized Bone Regeneration via Surface Lyophilization of Chondroitin Sulfate

Gong,

Yang,

Zhang

et al. 2023

Biomedicines

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Bone defect repair poses significant challenges in orthopedics, thereby increasing the demand for bone substitutes. Magnesium phosphate cements (MPCs) are widely used for bone defect repair because of their excellent mechanical properties and biodegradability. However, high crystallinity and uncontrolled magnesium ion (Mg2+) release limit the surface bioactivity of MPCs in bone regeneration. Here, we fabricate chondroitin sulfate (CS) as a surface coating via the lyophilization method, namely CMPC. We find that the CS coating is uniformly distributed and improves the mechanical properties of MPC through anionic electrostatic adsorption, while mediating degradation-related controlled ion release of Mg2+. Using a combination of in vitro and in vivo analyses, we show that the CS coating maintained cytocompatibility while increasing the cell adhesion area of MC3T3-E1s. Furthermore, we display accelerated osteogenesis and angiogenesis of CMPC, which are related to appropriate ion concentration of Mg2+. Our findings reveal that the preparation of a lyophilized CS coating is an effective method to promote surface bioactivity and mediate Mg2+ concentration dependent osteogenesis and angiogenesis, which have great potential in bone regeneration.

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Section: Effect Of Cs Coating On In Vitro Osteogenesismentioning

confidence: 99%

Functionalized Magnesium Phosphate Cement Induces In Situ Vascularized Bone Regeneration via Surface Lyophilization of Chondroitin Sulfate

Gong,

Yang,

Zhang

et al. 2023

Biomedicines

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“…The publications on using xanthan to obtain medical materials have appeared relatively recently. So, in the last two decades, researchers have taken an interest in its future use in drug delivery, tissue engineering, as well as biocomposites with regenerative and antibacterial properties [261][262][263][264][265][266][274][275][276][277][278][284][285][286][287][288][289][321][322][323][324][325][326][327][328].…”

Section: Applications Of Bc and Xanthanmentioning

confidence: 99%

“…Furthermore, Souza et al (2023) synthesized polymeric scaffolds of chitosan/xanthan/hydroxyapatite-graphene oxide nanocomposites associated with mesenchymal stem cells for regenerative dentistry applications [325]. Recently, Singh et al (2023) fabricated biomaterial composed of xanthan and diethylene glycol dimethacrylate with impregnation of graphite nanopowder filler in their matrices for effective bone tissue regeneration purposes with improved biomineralization [326]. Piola et al developed a crosslinked 3D-printable hydrogel based on biocompatible natural polymers, gelatin, and xanthan gum at different percentages to be used both as a scaffold for human keratinocyte and fibroblast cell growth and as a wound dressing (Figure 5F) [327].…”

Section: Applications Of Bc and Xanthanmentioning

confidence: 99%

Production of Bacterial Exopolysaccharides: Xanthan and Bacterial Cellulose

Revin,

Liyaskina,

Parchaykina

et al. 2023

IJMS

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Recently, degradable biopolymers have become increasingly important as potential environmentally friendly biomaterials, providing a wide range of applications in various fields. Bacterial exopolysaccharides (EPSs) are biomacromolecules, which due to their unique properties have found applications in biomedicine, foodstuff, textiles, cosmetics, petroleum, pharmaceuticals, nanoelectronics, and environmental remediation. One of the important commercial polysaccharides produced on an industrial scale is xanthan. In recent years, the range of its application has expanded significantly. Bacterial cellulose (BC) is another unique EPS with a rapidly increasing range of applications. Due to the great prospects for their practical application, the development of their highly efficient production remains an important task. The present review summarizes the strategies for the cost-effective production of such important biomacromolecules as xanthan and BC and demonstrates for the first time common approaches to their efficient production and to obtaining new functional materials for a wide range of applications, including wound healing, drug delivery, tissue engineering, environmental remediation, nanoelectronics, and 3D bioprinting. In the end, we discuss present limitations of xanthan and BC production and the line of future research.

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“…Thus far, several conductive materials have been recognized, i.e., polypyrrole (PPy), 17 polyaniline (PANI), 18 and poly (3,4-ethylenedioxythiophene) (PEDOT). 19,20 However, carbon-based materials, such as graphite, 21 ake graphene, graphene oxide, carbon nanobers, and carbon multiwalled nanotubes, offer considerable prospects and are subjected to intensive evaluation for such applications. 22 Especially, the 3D multiscale carbon-based formations were recently recognized as particularly interesting for bone tissue engineering applications owing to their exceptional mechanical and biological properties.…”

Section: Introductionmentioning

confidence: 99%

Deep eutectic solvent-assisted fabrication of bioinspired 3D carbon–calcium phosphate scaffolds for bone tissue engineering

et al. 2023

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Graphite nanopowder incorporated xanthan gum scaffold for effective bone tissue regeneration purposes with improved biomineralization

Cited by 8 publications

References 73 publications

Functionalized Magnesium Phosphate Cement Induces In Situ Vascularized Bone Regeneration via Surface Lyophilization of Chondroitin Sulfate

Functionalized Magnesium Phosphate Cement Induces In Situ Vascularized Bone Regeneration via Surface Lyophilization of Chondroitin Sulfate

Production of Bacterial Exopolysaccharides: Xanthan and Bacterial Cellulose

Deep eutectic solvent-assisted fabrication of bioinspired 3D carbon–calcium phosphate scaffolds for bone tissue engineering

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