Graphene quantum dots unraveling: Green synthesis, characterization, radiolabeling with 99mTc, in vivo behavior and mutagenicity

Menezes, Frederico Duarte de; Reis, Sara Rhaissa Rezende dos; Pinto, Suyene Rocha; Portilho, Filipe Leal; Mello, Francisco do Vale Chaves e; Helal-Neto, Edward; Silva, Aline Oliveira da; Alencar, Luciana Magalhães Rebêlo; Menezes, A.S. de; Santos, Clenilton Costa dos; Saraiva-Souza, Aldilene; Perini, Jamila Alessandra; Machado, Daniel Escorsim; Felzenswalb, Israel; Araújo-Lima, Carlos Fernando; Sukhanova, Alyona; Nabiev, Igor; Santos-Oliveira, Ralph

doi:10.1016/j.msec.2019.04.058

Cited by 43 publications

(20 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The in vivo investigation displayed an ubiquitous behavior when used for healthy animals, with a high uptake by liver (> 26%) and small intestine (> 25%). Furthermore, in inflammation/VEGF hyper-expression animal model (endometriosis), a very peculiar behavior of graphene quantum dots was detected, with a high uptake by kidneys (over 85%) (de Menezes et al 2019).…”

Section: Cytotoxicity Autophagy and Mutagenicitymentioning

confidence: 97%

“…Expectantly, increasing interest in the fabrication of these quantum dots, in view of their straightforward production and their integration with other nanomaterials, is sustainable. Although various processes and starting materials have been researched for their assembly, none or handful of these nanostructures have been able to make into marketable products yet (Liu et al 2017b;Wang et al 2016b;Murugan et al 2019;Halder et al 2018;Chen et al 2019;de Menezes et al 2019;Barras et al 2016;Nekoueian et al 2019;Li et al 2015;Mei et al 2016;Lin et al 2014).…”

Section: Challenges and Opportunitiesmentioning

confidence: 99%

“…Photoluminescence is one of the extremely attractive characteristics of carbon and graphene quantum dots, but these properties are highly dependent on the raw materials deployed in fabrication and the presence of surface functionalities on these particles which are noticeable in the case of carbon quantum dots from organic molecules and biomass. Most importantly, one of the lingering challenges has been to improve and develop the quantum yield of carbon quantum dots while taking full advantage of their intrinsic characteristics and to fine-tune their emission spectrum; the improvement in carbon quantum dots with strong fluorescence emission is crucial for biomedical imaging without harmful effects (Liu et al 2017b;Wang et al 2016b;Murugan et al 2019;Halder et al 2018;Chen et al 2019;de Menezes et al 2019;Barras et al 2016;Nekoueian et al 2019;Li et al 2015;Mei et al 2016;Lin et al 2014).…”

Section: Challenges and Opportunitiesmentioning

confidence: 99%

See 2 more Smart Citations

Green synthesis, biomedical and biotechnological applications of carbon and graphene quantum dots. A review

2020

View full text Add to dashboard Cite

Carbon and graphene quantum dots are prepared using top-down and bottom-up methods. Sustainable synthesis of quantum dots has several advantages such as the use of low-cost and non-toxic raw materials, simple operations, expeditious reactions, renewable resources and straightforward post-processing steps. These nanomaterials are promising for clinical and biomedical sciences, especially in bioimaging, diagnosis, bioanalytical assays and biosensors. Here we review green methods for the fabrication of quantum dots, and biomedical and biotechnological applications.

show abstract

Section: Cytotoxicity Autophagy and Mutagenicitymentioning

confidence: 97%

Section: Challenges and Opportunitiesmentioning

confidence: 99%

Section: Challenges and Opportunitiesmentioning

confidence: 99%

See 1 more Smart Citation

Green synthesis, biomedical and biotechnological applications of carbon and graphene quantum dots. A review

2020

View full text Add to dashboard Cite

show abstract

“…When a nanosystem acts at the same time as an imaging and therapeutic agent, it is known as a theranostic [53]. The imaging function can be achieved assembling nanosystems attached to radionuclides such as the technetium-99-metastable and other imaging agents which can give real-time information about the function of the nanosystem in the body [54,55].…”

Section: Nanosystemsmentioning

confidence: 99%

“…The strategies that has been developed and applied for years in nanosystems can be used and coupled with the ones that aim to modulate the ABC efflux function, enhancing the efficacy of today's formulations (e.g., all generations of ABC inhibitors) that still holds many issues as described before [46]. Graphene [55,56], silica mesoporous [57] and polymeric nanoparticles [58] are promising vehicles that can be built with high specificity to tumor cells, fulfilling these strategies [46].…”

Section: Nanosystemsmentioning

confidence: 99%

The Effect of Nanosystems on ATP-Binding Cassette Transporters: Understanding the Influence of Nanosystems on Multidrug Resistance Protein-1 and P-glycoprotein

Mello

Moraes

Maia

et al. 2020

IJMS

Self Cite

View full text Add to dashboard Cite

The cancer multidrug resistance is involved in the failure of several treatments during cancer treatment. It is a phenomenon that has been receiving great attention in the last years due to the sheer amount of mechanisms discovered and involved in the process of resistance which hinders the effectiveness of many anti-cancer drugs. Among the mechanisms involved in the multidrug resistance, the participation of ATP-binding cassette (ABC) transporters is the main one. The ABC transporters are a group of plasma membrane and intracellular organelle proteins involved in the process of externalization of substrates from cells, which are expressed in cancer. They are involved in the clearance of intracellular metabolites as ions, hormones, lipids and other small molecules from the cell, affecting directly and indirectly drug absorption, distribution, metabolism and excretion. Other mechanisms responsible for resistance are the signaling pathways and the anti- and pro-apoptotic proteins involved in cell death by apoptosis. In this study we evaluated the influence of three nanosystem (Graphene Quantum Dots (GQDs), mesoporous silica (MSN) and poly-lactic nanoparticles (PLA)) in the main mechanism related to the cancer multidrug resistance such as the Multidrug Resistance Protein-1 and P-glycoprotein. We also evaluated this influence in a group of proteins involved in the apoptosis-related resistance including cIAP-1, XIAP, Bcl-2, BAK and Survivin proteins. Last, colonogenic and MTT (3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide) assays have also been performed. The results showed, regardless of the concentration used, GQDs, MSN and PLA were not cytotoxic to MDA-MB-231 cells and showed no impairment in the colony formation capacity. In addition, it has been observed that P-gp membrane expression was not significantly altered by any of the three nanomaterials. The results suggest that GQDs nanoparticles would be suitable for the delivery of other multidrug resistance protein 1 (MRP1) substrate drugs that bind to the transporter at the same binding pocket, while MSN can strongly inhibit doxorubicin efflux by MRP1. On the other hand, PLA showed moderate inhibition of doxorubicin efflux by MRP1 suggesting that this nanomaterial can also be useful to treat MDR (Multidrug resistance) due to MRP1 overexpression.

show abstract

Carbon Nanomaterials‐Based Drug Delivery Systems: Synthesis, DFT Drug Interactions, and Cancer Therapy

Sawy

Barhoum

Shousha

et al. 2023

Supramolecular Nanotechnology

View full text Add to dashboard Cite

Graphene quantum dots unraveling: Green synthesis, characterization, radiolabeling with 99mTc, in vivo behavior and mutagenicity

Cited by 43 publications

References 39 publications

Green synthesis, biomedical and biotechnological applications of carbon and graphene quantum dots. A review

Green synthesis, biomedical and biotechnological applications of carbon and graphene quantum dots. A review

The Effect of Nanosystems on ATP-Binding Cassette Transporters: Understanding the Influence of Nanosystems on Multidrug Resistance Protein-1 and P-glycoprotein

Carbon Nanomaterials‐Based Drug Delivery Systems: Synthesis, DFT Drug Interactions, and Cancer Therapy

Contact Info

Product

Resources

About