Graphene quantum dots as a new substrate for immobilization and direct electrochemistry of glucose oxidase: Application to sensitive glucose determination

Razmi, Habib; Mohammad‐Rezaei, Rahim

doi:10.1016/j.bios.2012.09.009

Cited by 291 publications

(130 citation statements)

References 42 publications

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“…Especially, the emission from carbon dots could be efficiently quenched by either electron acceptor or donor molecules in solution, indicating that the photo-excited carbon dots are excellent as both electron donors and electron acceptors. Therefore, unlike the common carbon material, carbon dot with small size, provide high electrocatalytic activity owing to the large surface area [33][34][35], but they lower electron transport efficiency owing to the oxygen-rich functional groups, abundant grain boundaries, and defects [36]. This suggests the single carbon dots as the electrode material is not a good choice.…”

Section: Introductionmentioning

confidence: 96%

Carbon dots-decorated multiwalled carbon nanotubes nanocomposites as a high-performance electrochemical sensor for detection of H2O2 in living cells

2016

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A novel enzyme-free hydrogen peroxide sensor composed of carbon dots (CDs) and multi-walled carbon nanotubes (MWCNTs) was prepared. It was found that the carbon dots-decorated multi-walled carbon nanotubes nanocomposites (CDs/MWCNTs) modified glassy carbon (GC) electrode (CDs/MWCNTs/GCE) exhibited a significant synergistic electrocatalytic activity towards hydrogen peroxide reduction as compared to carbon dots or multi-walled carbon nanotubes alone, and the CDs/MWCNTs/GCE has shown a low detection limit as well as excellent stability, selectivity, and reproducibility. These remarkable analytical advantages enable the practical application of CDs/MWCNTs/GCE for the real-time tracking of hydrogen peroxide (H2O2) released from human cervical cancer cells with satisfactory results. The enhanced electrochemical activity can be assigned to the edge plane-like defective sites and lattice oxygen in the CDs/MWCNTs nanocomposites due to the small amount of decoration of carbon dots on the multi-walled carbon nanotubes. Based on a facile preparation method and with good electrochemical properties, the CDs/MWCNTs nanocomposites represent a new class of carbon electrode for electrochemical sensor applications. Graphical Abstract CDs/MWCNTs exhibited good electrocatalytic activity and stability to H2O2 reduction and can be used for real-time detection of H2O2 released from living cells.

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Section: Introductionmentioning

confidence: 96%

Carbon dots-decorated multiwalled carbon nanotubes nanocomposites as a high-performance electrochemical sensor for detection of H2O2 in living cells

2016

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“…5a, blue dot line) is 476 Ω, ten times of that of NS-C, which suggests that the NS-C is more favorable for interfacial electron transfer of the redox probe and has a faster electron transfer rate [17]. This can be possibly explained by that the additional N/S-doping in NS-C creates asymmetrical spin and charge density owing to the synergetic effect of N and S atoms [50], which further facilitates the interfacial electron transfer of the redox probe to electrode.…”

Section: Science China Materialsmentioning

confidence: 96%

“…, and the detection limit was calculated to be 1.73 μmol L −1 with a sensitivity of 0.085 μA cm −2 μmol −1 L [17]. By contrast with graphene nanosheets modified GCE electrode [18] and acetylene black modified GCE electrode [19], the HTC based electrodes have less unbound electron, larger transfer resistance in the electrochemical impedance spectra and result in poor sensitivity when applied in biosensors [20].…”

Section: Introductionmentioning

confidence: 99%

Ultra-low charge transfer resistance carbons by one-pot hydrothermal method for glucose sensing

Liu

Zhao

et al. 2017

Sci. China Mater.

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Hydrothermal carbon (HTC) is typically welldispersed, but it remains a great challenge for HTC to become conductive. Co-doping with heteroatoms has been confirmed to be an effective strategy to significantly promote the electrical conductivity of carbon. Moreover, there is no simple and green method to construct sensitive HTC based electrochemical biosensors until now. In this paper, N and S dualdoped carbon (NS-C) with ultra-low charge transfer resistance is easily synthesized from L-cysteine and glucose in a hydrothermal reaction system. The morphology, structural properties and electrochemical properties of the as-prepared NS-C are analyzed. In comparison with the undoped hydrothermal (UC) modified glassy carbon electrode (GCE), the charge transfer resistance of UC (476 Ω , indicating a high affinity of glucose oxidase to glucose. These results demonstrate that the hydrothermal method is an effective way for preparing high electrical conductivity carbon with excellent performances in biosensor application.

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“…Many nanomaterials, such as carbon nanotubes [5,18], gold nanoparticles [19,20], and metal oxides [21,22] have been used in biosensors. More recently a new class of carbon material, graphene, which is a twodimensional sheet of carbon atoms, has attracted increasing attention with respect to its potential applications in phtoelectronic devices, supercapacitors, sensors and nanocomposites applications [6,[23][24][25][26][27][28][29][30][31][32]. Due to their planar morphology and thus larger accessible surface area, graphene may perform better than any other carbon-based materials for an electrode sensor fabrication.…”

Section: Introductionmentioning

confidence: 99%

Graphene modified electrospun poly(vinyl alcohol) nanofibrous membranes for glucose oxidase immobilization

Wu¹,

Yu²,

Lin³

2014

Express Polym. Lett.

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Abstract. In this study, poly(vinyl alcohol) (PVA)/Glucose oxidase (GOx)/graphene biocomposite membranes were prepared using an electrospinning technique and used for enzyme immobilization. The PVA/GOx/graphene membrane's morphology was examined by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), while its electrochemical sensitivity was studied by chronoamperometry. Kinetic parameters were determined to clarify the role of graphene in enzyme immobilization, while a spectrophotometric assay was used to quantify the active enzyme. The results indicated that the presence of graphene helps to stabilize the enzyme's conformation, facilitate the catalytic reaction, and increase the survivability of the enzyme.

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Graphene quantum dots as a new substrate for immobilization and direct electrochemistry of glucose oxidase: Application to sensitive glucose determination

Cited by 291 publications

References 42 publications

Carbon dots-decorated multiwalled carbon nanotubes nanocomposites as a high-performance electrochemical sensor for detection of H2O2 in living cells

Carbon dots-decorated multiwalled carbon nanotubes nanocomposites as a high-performance electrochemical sensor for detection of H2O2 in living cells

Ultra-low charge transfer resistance carbons by one-pot hydrothermal method for glucose sensing

Graphene modified electrospun poly(vinyl alcohol) nanofibrous membranes for glucose oxidase immobilization

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