Graphene Oxide Wrapped SiO<sub>2</sub>/TiO<sub>2</sub> Hollow Nanoparticles Loaded with Photosensitizer for Photothermal and Photodynamic Combination Therapy

Jang, Yoonsun; Kim, Sojin; Lee, Seungae; Yoon, Chang‐Min; Lee, Inkyu; Jang, Jyongsik

doi:10.1002/chem.201605112

Cited by 42 publications

(18 citation statements)

References 54 publications

(110 reference statements)

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“…These findings promise the potential use of this system for complete tumor ablation and metastasis prevention. Several research groups have designed hybrid materials comprising photosensitizer-linked graphene/GO (GO-fullerene C60) [72], RGO-Ru-PEG [73], folic acid-GO-manganese dioxide [74], GO-enwrapped SiO 2 /TiO 2 hollow nanoparticles loaded with protoporphyrin IX [75], and NGO-UCNP-Ce6 [76] for combined PTT and PDT in a single platform. Effective delivery of photosensitizers for PDT along with enhanced fluorescence imaging was achieved by Yan et al [77].…”

Section: Graphene Substrates For Photothermal Therapy and Photodynamimentioning

confidence: 99%

Comprehensive Application of Graphene: Emphasis on Biomedical Concerns

2019

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HIGHLIGHTS• The introduction of graphene will certainly uncover new advanced materials, and many more future technologies will become realistic in the forthcoming years.• The present review article includes more recent publications about the biomedical application and cellular interaction of graphene. It is also updated with modern approaches such as use of graphene inks for 3D printing application.• Moreover, the importance of protein corona in modulating the cellular interaction, which was overlooked in previous review publications, is also included in this article.• The possible biological outcomes and toxicity when graphene is exposed to living organisms at the cellular and organ level are explained.ABSTRACT Graphene, sp 2 hybridized carbon framework of one atom thickness, is reputed as the strongest material to date. It has marked its impact in manifold applications including electronics, sensors, composites, and catalysis. Current state-of-the-art graphene research revolves around its biomedical applications. The two-dimensional (2D) planar structure of graphene provides a large surface area for loading drugs/biomolecules and the possibility of conjugating fluorescent dyes for bioimaging. The high near-infrared absorbance makes graphene ideal for photothermal therapy. Henceforth, graphene turns out to be a reliable multifunctional material for use in diagnosis and treatment.It exhibits antibacterial property by directly interacting with the cell membrane. Potential application of graphene as a scaffold for the attachment and proliferation of stem cells and neuronal cells is captivating in a tissue regeneration scenario. Fabrication of 2D graphene into a 3D structure is made possible with the help of 3D printing, a revolutionary technology having promising applications in tissue and organ engineering. However, apart from its advantageous application scope, use of graphene raises toxicity concerns. Several reports have confirmed the potential toxicity of graphene and its derivatives, and the inconsistency may be due to the lack of standardized consensus protocols. The present review focuses on the hidden facts of graphene and its biomedical application, with special emphasis on drug delivery, biosensing, bioimaging, antibacterial, tissue engineering, and 3D printing applications.

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Section: Graphene Substrates For Photothermal Therapy and Photodynamimentioning

confidence: 99%

Comprehensive Application of Graphene: Emphasis on Biomedical Concerns

2019

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“…Authors of this work reported that an anticancer effect of 13 times more than the previous study was obtained using GO@SiO 2 /TiO 2 nanocomposite. Multi functionality of this nanocomposite showed potential for loading of anticancer drug protoporphyrinIX and efficient for both PDT and PTT [18]. A nanocomposite of rGO@phosphorescent PEG modified Ru (II) complex (Ru-PEG) also developed and is very effective for both PTT and PDT.…”

Section: Drug Delivery and Cancer Therapymentioning

confidence: 99%

Graphene Oxide for Biomedical Applications

K¹,

Modak²,

Paik³

2017

JNMR

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Graphene oxide (GO) is one of the most promising functional materials used in various applications like energy storage (batteries and supercapacitors) sensors, photocatalysis, electronics and in biomedicine. The last 10 years literature on GO for biomedical applications revealed and confirmed the scope of its potential capabilities as biomaterial. GO alone and its modified form with different materials (surface functionalization, immobilization of nanoparticles and composite formation) also proved as a multifunctional candidate for medical biotechnology. A material for its use in biomedical applications must be biocompatible and nontoxic to the living cells.. Although there are some concerns about the toxicity of the GO in specific cases, a dosage range and size effects reported in the literature to use it as a nontoxic materials. In view of all these points, an effort has been made to review and emphasize the scope of GO as a biomedical agent for the applications like targeted drug delivery, cancer theranostics, bioimaging and biosensors etc. Further, potential applications along with the future scope and limitations of GO have also been highlighted in this review.

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“…Till now, a series of photosensitizer agents, including phthalocyanine green (ICG) [35], dihydroporphyrin (Ce6) [36], hematoporphyrin (HP) [37], pheophytin [38], protoporphyrin IX (PpIX) [39][40][41], have been developed. However, the traditional PDT treatment suffers from several drawbacks such as high oxygen dependent, poor water solubility and poor targeting of photosensitizer.…”

Section: Introductionmentioning

confidence: 99%

SERS imaging elucidates the folate receptor-mediated photothermal/photodynamic synergistic anticancer nanodrugs-induced cell apoptosis

Tang¹,

Xing²,

Tao³

et al. 2020

Preprint

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Background: Chemotherapy and radiotherapy are common methods of cancer treatment, but they are accompanied by serious side effects. Actually, many cancer cells have overexpression of folic acid (FA) receptor and by FA receptor-mediated endocytosis, anticancer drugs can be easily internalized into cancer cell, this will greatly improve the curative effect and decrease side effects. Along with the development of nanotechnology, phototherapy, owning advantages in tissue selectivity, process controlling, low toxicity and reproducible treatment, has become very promising, especially for photothermal therapy (PTT) and photodynamic therapy (PDT). Since both PTT and PDT involve the utilization of light energy, so they synergistic treatment should be a good solution by ingenious design. In this paper, based on surface enhanced Raman spectroscopy (SERS) imaging, we hope to construct a FA receptor-mediated PTT/PDT synergistic anticancer nanodrug (nanoprobe), and achieve the intracellular distribution information of the nanodrugs during cell apoptosis, and then elucidate PTT/PDT-induced cell apoptosis and synergistic efficiency.Results: FA receptor-mediated PTT/PDT synergistic anticancer nanodrugs with tracing function are prepared by the chemical synthesis and modification of gold nanorods (GNR), involving protoporphyrin IX (PpIX), 4-mecaptobenzoic acid (MBA), and FA. Based on SERS imaging, it is found that the FA receptor-mediated endocytosis can greatly facilitate the nanodrugs internalization, in which both the number and intracellular dispersion of the PpIX-GNR-MBA-FA nanodrugs are improved relative to the GNR-MBA or PpIX-GNR-MBA compositions, and then enhance the PTT/PDT-induced cell apoptosis.Conclusion: SERS imaging is very suitable for the phototherapy tracing due to its high sensitivity and stability. The FA receptor-mediated way can significantly facilitate nanodrugs internalization, PTT/PDT-induced cell apoptosis and synergistic efficiency. Importantly, this FA receptor-mediated SERS imaging based PTT/PDT synergistic treatment will provide a novel strategy for the design and application of anticancer phototherapy nanodrugs.

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Graphene Oxide Wrapped SiO₂/TiO₂ Hollow Nanoparticles Loaded with Photosensitizer for Photothermal and Photodynamic Combination Therapy

Cited by 42 publications

References 54 publications

Comprehensive Application of Graphene: Emphasis on Biomedical Concerns

Comprehensive Application of Graphene: Emphasis on Biomedical Concerns

Graphene Oxide for Biomedical Applications

SERS imaging elucidates the folate receptor-mediated photothermal/photodynamic synergistic anticancer nanodrugs-induced cell apoptosis

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Graphene Oxide Wrapped SiO2/TiO2 Hollow Nanoparticles Loaded with Photosensitizer for Photothermal and Photodynamic Combination Therapy

Cited by 42 publications

References 54 publications

Comprehensive Application of Graphene: Emphasis on Biomedical Concerns

Comprehensive Application of Graphene: Emphasis on Biomedical Concerns

Graphene Oxide for Biomedical Applications

SERS imaging elucidates the folate receptor-mediated photothermal/photodynamic synergistic anticancer nanodrugs-induced cell apoptosis

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Graphene Oxide Wrapped SiO₂/TiO₂ Hollow Nanoparticles Loaded with Photosensitizer for Photothermal and Photodynamic Combination Therapy