Graphene Oxide Quantum Dots Reduce Oxidative Stress and Inhibit Neurotoxicity In Vitro and In Vivo through Catalase‐Like Activity and Metabolic Regulation

Ren, Chaoxiu; Hu, Xiangang; Zhou, Qixing

doi:10.1002/advs.201700595

Cited by 143 publications

(101 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In particular, the greatest challenge to date for overtaking biological barriers is represented by the blood-brain barrier (BBB) ( Figure 4A). From an anatomical point of view, the BBB is constituted by Ren and colleagues demonstrated a reduction in apoptosis and oxidative stress mediated by 1-methyl-4-phenyl-pyridinium ion (MPP+) when PC12 cells were treated GQDs, thus showing neuroprotective effects of these nanomaterials [65]. Neuroprotection was furtherly confirmed in the same work in vivo on zebrafish ( Figure 3C,D).…”

Section: Overtaking the Blood-brain Barrier (Bbb) With Gqdsmentioning

confidence: 60%

“…Reproduced with permission[38]; (C) Oxidative stress on zebrafish after the treatment with MMP and GQDs with relative fluorescence intensity on head and heart. Reprinted from[65]; (D) Fluorescence intensity of caspase-3 after the treatment with GQDs and MMP[65]; (E) In vivo and ex vivo imaging of mouse after injection with carboxylated GQDs[67]; (F) Accumulation of different concentrations of carboxylated GQDs in mouse organs, 160× magnification. E and F were reprinted with permission[67].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Unravelling the Potential of Graphene Quantum Dots in Biomedicine and Neuroscience

Perini

Palmieri

Ciasca

et al. 2020

IJMS

View full text Add to dashboard Cite

Quantum dots (QDs) are semiconducting nanoparticles that have been gaining ground in various applications, including the biomedical field, thanks to their unique optical properties. Recently, graphene quantum dots (GQDs) have earned attention in biomedicine and nanomedicine, thanks to their higher biocompatibility and low cytotoxicity compared to other QDs. GQDs share the optical properties of QD and have proven ability to cross the blood-brain barrier (BBB). For this reason, GQDs are now being employed to deepen our knowledge in neuroscience diagnostics and therapeutics. Their size and surface chemistry that ease the loading of chemotherapeutic drugs, makes them ideal drug delivery systems through the bloodstream, across the BBB, up to the brain. GQDs-based neuroimaging techniques and theranostic applications, such as photothermal and photodynamic therapy alone or in combination with chemotherapy, have been designed. In this review, optical properties and biocompatibility of GQDs will be described. Then, the ability of GQDs to overtake the BBB and reach the brain will be discussed. At last, applications of GQDs in bioimaging, photophysical therapies and drug delivery to the central nervous system will be considered, unraveling their potential in the neuroscientific field.

show abstract

Section: Overtaking the Blood-brain Barrier (Bbb) With Gqdsmentioning

confidence: 60%

mentioning

confidence: 99%

Unravelling the Potential of Graphene Quantum Dots in Biomedicine and Neuroscience

Perini

Palmieri

Ciasca

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Antioxidants can not only scavenge the ROS in body but can also regulate ROS related enzymes such as radical generating NAD(P)H oxidase and xanthine oxidase (XO) or radical reducing superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) . Out of these enzymes, SOD converts two O 2 .− into one H 2 O 2 and one oxygen molecule;

true normalO_{2}^{•}^{-} + normalO_{2}^{•}^{-} + 2 H^{+} \overset{SOD}{true} normalO_{2} + normalH_{2} normalO_{2}

…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity and Hepatotoxicity of Flavonoids and Their Metal Complexes Through Co‐Administration of β‐Cyclodextrin

et al. 2019

View full text Add to dashboard Cite

The in vivo determination of radical scavenging activity of flavonoids (Fls) and their metal complexes (M‐Fls) through co‐administration of 2‐hydroxypropyl beta‐cyclodextrin (HP‐βCD) was determined. The flavonoids morin (mo), quercetin (quer), primuletin (prim), their Cu (II) and Fe (III) complexes were selected to explore their radical scavenging potential. Metal complexes of flavonoids (M‐Fls) showed better radical scavenging activity RSA when injected to rats than corresponding flavonoids. The RSA is improved in the presence of HP‐βCD. This increase in RSA was assisted by enhanced enzymatic activity of catalase (CAT) and superoxide dismutase (SOD) activity. The compounds displayed hepatoprotection against alloxan induced liver damage as flavonoid injected group displayed lower levels of enzymes and intermediates aspartate/alanine transaminase (AST), alanine aminotransferase (ALT), Lipid peroxidation (MDA), Hydroxyproline (HYP), Sailic acid (SA) and higher albumin and total proteins level compared with alloxan treated group. It was evaluated by histopathological investigations that M‐Fls restored the hepatic damage caused by alloxan. The binding constants values of the compounds with human plasma (n‐HP) revealed the order of 103‐104 L−1. The binding interactions of the compounds with human plasma in the presence of HP‐βCD is decreased which in turns increased the RSA as well as CAT and SOD activities. Based upon our results, it was concluded that radical scavenging activities and hepatoprotective activities of M‐Fls is increased when co‐administrated with HP‐βCD.

show abstract

“…Graphene oxide quantum dots alleviated oxidative stress in vivo and rescued neurons against PDrelated degeneration in vitro, through catalase-like activity and metabolic regulation. [167] Hydrophilic carbon clusters (HCCs), a class of graphitic NPs, are likewise considered as potent antioxidants that could be helpful for several diseases of the nervous system. [168,169] Mechanistic studies of non-toxic HCCs confirm their ability to selectively catalyze the dismutation of oxygen radicals.…”

Section: (7 Of 24)mentioning

confidence: 99%

Redox‐Responsive Nanobiomaterials‐Based Therapeutics for Neurodegenerative Diseases

Eleftheriadou

Kesidou

Moura

et al. 2020

Small

View full text Add to dashboard Cite

dementia, which result from chronic and progressive loss of neuronal function. In view of an ageing population, disorders of the brain are likely to establish the principal economic challenge in the future of healthcare. [1] The total cost of dementia to society in the UK alone is £26.3 billion, and this is expected to double over the next 30 years given that prevalence is projected to rise by 40% in the coming decade alone. [2] Among NDs, significant attention has been paid to Alzheimer's disease (AD) and Parkinson's disease (PD) given their severe complications and economic burdens. AD, which accounts for the vast majority of age-related dementia, is a progressive disorder that is characterized by gradual neuronal loss and accumulation of proteins, namely extracellular amyloid-β plaques and intracellular tau tangles. [3] PD is a progressive ND resulting from the loss of specific dopaminergic (DA) neurons in the substantia nigra pars compacta and reduced DA levels in the nigrostriatal DA pathway in the brain. [4,5] Despite significant progress in the management of NDs over the recent years, the early diagnostic and treatment options remain limited. Patients currently suffering from NDs have no available disease-modifying treatments. Instead, patients are offered a therapeutic plan focused on the management of their ND symptoms, whilst concurrently attempting to reduce the adverse effects associated with the medications used. The systemic delivery of drugs to the central nervous system (CNS) is complex due to their poor delivery to the brain, extensive firstpass metabolism which reduces their half-life, and the sideeffects resulting from the drug acting on non-target peripheral tissues. [6] The mainstay of current treatments for NDs is typically through oral administration. For PD medications include L-dopa, carbidopa (peripheral inhibitor of L-dopa into DOPA), dopaminergic agonists, Entacapone (Catechol-O-methyl transferase inhibitor), monoamine oxidase-B inhibitors, amongst others. Other routes of drug administration exist such as subcutaneous injection of dopaminergic agonists. Interestingly, deep brain stimulation has also been offered to those patients resistant to medical therapy but again associated with significant adverse effects. L-Dopa, which is considered the most effective treatment in the short-term for PD, [7] is related to longterm wearing-off phenomena, dyskinesias, and neuropsychiatric disorders. [8] Redox regulation has recently been proposed as a critical intracellular mechanism affecting cell survival, proliferation, and differentiation. Redox homeostasis has also been implicated in a variety of degenerative neurological disorders such as Parkinson's and Alzheimer's disease. In fact, it is hypothesized that markers of oxidative stress precede pathologic lesions in Alzheimer's disease and other neurodegenerative diseases. Several therapeutic approaches have been suggested so far to improve the endogenous defense against oxidative stress and its harmful effects. Among such approaches, the use o...

show abstract

Graphene Oxide Quantum Dots Reduce Oxidative Stress and Inhibit Neurotoxicity In Vitro and In Vivo through Catalase‐Like Activity and Metabolic Regulation

Cited by 143 publications

References 64 publications

Unravelling the Potential of Graphene Quantum Dots in Biomedicine and Neuroscience

Unravelling the Potential of Graphene Quantum Dots in Biomedicine and Neuroscience

Antioxidant Activity and Hepatotoxicity of Flavonoids and Their Metal Complexes Through Co‐Administration of β‐Cyclodextrin

Redox‐Responsive Nanobiomaterials‐Based Therapeutics for Neurodegenerative Diseases

Contact Info

Product

Resources

About