Graphene oxide leads to mitochondrial-dependent apoptosis by activating ROS-p53-mPTP pathway in intestinal cells

Feng, Weiyu; Wang, Jinbang; Li, Baodong; Liu, Yonggang; Xu, Dongli; Cheng, Ke; Zhuang, Jing

doi:10.1016/j.biocel.2022.106206

Cited by 12 publications

(6 citation statements)

References 59 publications

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“…In addition, we found that the highly expressed DEGs in hypertrophied crop tissue were enriched in terms related to respiration chain ( Fig 2C and S2-II Appendix ), which might reflect the accumulation of macromolecules (lipids and proteins, etc .) leading to the generation of reactive oxygen species [ 55 , 56 ] and subsequent induction of apoptosis [ 57 ]. As expected, CASP3 (pro-apoptotic factors) was up-regulated, while BCL2 (anti-apoptotic factors) was down-regulated ( Fig 2C ) during the hypertrophy period.…”

Section: Resultsmentioning

confidence: 99%

Spatio-temporal transcriptome dynamics coordinate rapid transition of core crop functions in ‘lactating’ pigeon

Wang,

Luo

et al. 2023

PLoS Genet

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Pigeons (Columba livia) are among a select few avian species that have developed a specialized reproductive mode wherein the parents produce a ‘milk’ in their crop to feed newborn squabs. Nonetheless, the transcriptomic dynamics and role in the rapid transition of core crop functions during ‘lactation’ remain largely unexplored. Here, we generated a de novo pigeon genome assembly to construct a high resolution spatio-temporal transcriptomic landscape of the crop epithelium across the entire breeding stage. This multi-omics analysis identified a set of ‘lactation’-related genes involved in lipid and protein metabolism, which contribute to the rapid functional transitions in the crop. Analysis of in situ high-throughput chromatin conformation capture (Hi-C) sequencing revealed extensive reorganization of promoter-enhancer interactions linked to the dynamic expression of these ‘lactation’-related genes between stages. Moreover, their expression is spatially localized in specific epithelial layers, and can be correlated with phenotypic changes in the crop. These results illustrate the preferential de novo synthesis of ‘milk’ lipids and proteins in the crop, and provides candidate enhancer loci for further investigation of the regulatory elements controlling pigeon ‘lactation’.

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Section: Resultsmentioning

confidence: 99%

Spatio-temporal transcriptome dynamics coordinate rapid transition of core crop functions in ‘lactating’ pigeon

Wang,

Luo

et al. 2023

PLoS Genet

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“…The occurrence of apoptosis is affected by many factors, among which ROS has been confirmed to be one of the essential inducements of apoptosis ( Yan et al, 2022 ). Some studies indicated that under stress, cells produced a large amount of ROS, which promoted the conformation of MPTP between the inner and outer mitochondrial membranes to change, and various pro-apoptotic factors were released from the pores in large quantities, eventually triggering the apoptosis cascade ( Li et al, 2018 ; Feng et al, 2022 ). Wang et al reported that mitochondrial membrane potential decreased significantly during postmortem aging of yak meat, which was consistent with the results of this experiment ( Wang et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary supplementation with selenium yeast and jujube powder on mitochondrial oxidative damage and apoptosis of chicken

Yang

Tang

et al. 2022

Poultry Science

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“…In contrast, COX-2 overexpression can reduce IEC apoptosis induced by Giardia . Increased ROS levels and decreased NO levels have been identified as stimuli leading to IEC apoptosis ( 157 , 158 ). The levels of ROS/NO may be influenced by COX-2 expression, which is regulated by MAPK/AKT/NF-κB signaling ( 159 , 160 ).…”

Section: Extracellular Parasitesmentioning

confidence: 99%

The roles of COX-2 in protozoan infection

2023

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Protozoan diseases cause great harm in animal husbandry and require human-provided medical treatment. Protozoan infection can induce changes in cyclooxygenase-2 (COX-2) expression. The role played by COX-2 in the response to protozoan infection is complex. COX-2 induces and regulates inflammation by promoting the synthesis of different prostaglandins (PGs), which exhibit a variety of biological activities and participate in pathophysiological processes in the body in a variety of ways. This review explains the roles played by COX-2 in protozoan infection and analyzes the effects of COX-2-related drugs in protozoan diseases.

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Graphene oxide leads to mitochondrial-dependent apoptosis by activating ROS-p53-mPTP pathway in intestinal cells

Cited by 12 publications

References 59 publications

Spatio-temporal transcriptome dynamics coordinate rapid transition of core crop functions in ‘lactating’ pigeon

Spatio-temporal transcriptome dynamics coordinate rapid transition of core crop functions in ‘lactating’ pigeon

Effects of dietary supplementation with selenium yeast and jujube powder on mitochondrial oxidative damage and apoptosis of chicken

The roles of COX-2 in protozoan infection

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