Graphene Oxide/Gold Nanorod Nanocomposite for Stable Surface-Enhanced Raman Spectroscopy

Vianna, Pilar G.; Grasseschi, Daniel; Costa, G.; Carvalho, Isabel C. S.; Domingues, Sergio H.; Fontana, Jake; Matos, Christiano J. S. de

doi:10.1021/acsphotonics.6b00109

Cited by 42 publications

(31 citation statements)

References 58 publications

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“…Because of requiring only a small sample volume and high sensitivity and selectivity, SERS based techniques have shown great potential as a point-of-care platform for point-of-care diagnostics of diseases in field tests 7 , 8 . However, one major drawback of conventional silver based SERS substrates is their poor physical stability and strict storage conditions for SERS activity preservation, which has limited the application of SERS based field biosensing 9 , 10 .…”

Section: Introductionmentioning

confidence: 99%

“…An oxidized layer will be formed in a short time once pure silver is exposed to air, which makes sustained SERS performance in the long term difficult. Conventionally, in order to improve the performance and stability of SERS based sensors 9 , 10 , metallic nanostructures are usually covered by a protective agent such as metal oxide (Fe 3 O 4 , ZnO) 13 , 22 , semiconductor quantum dots (CdSe, CdS) or carbon materials 23 , 24 . Among these materials, graphene often exihibits a highter SERS effect after target molecules are adsorbed on a monolayer graphene surface 25 – 28 .…”

Section: Introductionmentioning

confidence: 99%

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Sustained and Cost Effective Silver Substrate for Surface Enhanced Raman Spectroscopy Based Biosensing

Liu

Perlaki

et al. 2017

Sci Rep

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While surface enhanced Raman spectroscopy (SERS) based biosensing has demonstrated great potential for point-of-care diagnostics in the laboratory, its application in the field is limited by the short life time of commonly used silver based SERS active substrates. In this work, we report our attempt towards SERS based field biosensing, involving the development of a novel sustained and cost-effective substrate composed of silver nanoparticles protected by small nitrogen-doped Graphene Quantum Dots, i.e. Ag NP@N-GQD, and its systematic evaluation for glucose sensing. The new substrate demonstrated significantly stronger Raman enhancement compared to pure silver nanoparticles. More importantly, the new substrate preserved SERS performance in a normal indoor environment for at least 30 days in both the wet and dry states, in contrast to only 10 days for pure silver nanoparticles. The Ag NP@N-GQD thin film in the dry state was then successfully applied as a SERS substrate for glucose detection in mouse blood samples. The new substrate was synthesized under mild experimental conditions, and the cost increase due to N-GQD was negligible. These results suggest that the Ag NP@N-GQD is a cost-effective and sustained SERS substrate, the development of which represents an important step towards SERS based field biosensing.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sustained and Cost Effective Silver Substrate for Surface Enhanced Raman Spectroscopy Based Biosensing

Liu

Perlaki

et al. 2017

Sci Rep

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“…The Raman peak at 1362 cm À1 could be assigned to the methine chain deformationo fC y5, [39,46] and the peaks at 1215 and 1595 cm À1 were assigned to n(C=C) (benzene) and n sy (CÀC) (benzene ring) in Cy5,r espectively. [47] The peak intensity at 1362 cm À1 decayed rapidly from A5 to A30, andt hen tended to as teady value ( Figure 2B). The peak intensities at 1215a nd 1595 cm À1 showed as imilar variation tendency ( Figure S4 A,B, Supporting Information).…”

Section: Resultsmentioning

confidence: 90%

Polyadenine‐Modulated DNA Conformation Monitored by Surface‐Enhanced Raman Scattering (SERS) on Multibranched Gold Nanoparticles and Its Sensing Application

Guo

Chen

Jiang

et al. 2017

Chemistry A European J

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This work proposes a facile way to modulate the conformation of DNA from the "Lie-Down" to the "Stand-Up" conformation on the surface of multibranched gold nanoparticles (AuNPs). This is realized by regulating the length of polyadenine (polyA) linked to the DNA sequence and/or the hybridization of this sequence with the target DNA, and can be monitored by the Raman signal owing to the excellent performance of multibranched AuNPs (AuNSs) as a surface-enhanced Raman scattering (SERS) substrate and the distance change between the Raman reporter and the substrate. The probable mechanism, which depends on the repulsion of polyA from the sequence and the tip assembly, has also been probed through theoretical simulation using the finite difference time domain method. By virtue of this strategy, a conformation-transformation-based DNA@AuNS sensor is constructed for the identification of a specific oligonucleotide, which has been used for the detection of DNA sequences associated with Severe Acute Respiratory Syndrome (SARS). This strategy leads to a novel sensing platform with good extendibility for DNA analysis, and provides a powerful protocol for facilitating the cognition of DNA conformation on metal surfaces.

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“…Recently, much effort of scientists has been devoted to enhancing optoelectronic response of Raman probe through fabricating organic–inorganic hybrid structures . The composites are useful not only for exploring the fundamental properties of the hybrid structure but also for creating new functional sensors with higher sensitivity.…”

Section: Introductionmentioning

confidence: 99%

In‐Situ covalent synthesis of gold nanorods on GO surface as ultrasensitive Raman probe

Guo

Geng

et al. 2019

Applied Organom Chemis

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In this paper, using thiolated graphene oxide (GO‐O‐SH) as substrate, gold nanorods (AuNRs) covalently linked to the GO surface by in‐situ seed growth method were first reported. The as‐prepared composites were characterized by UV–vis spectrum, transmission electron microscopy (TEM), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT‐IR). Experimental results indicated that the introduction of short flexible organic chain between GO and AuNRs contributed to the homogenous synthesis of gold rods, and uniform gold nanorods with aspect ratio within 3~8 were covalently linked to the surface of GO with high stability and yield. The strategy represented an outstanding improvement in comparison to the traditional route for fabricating GO@AuNRs composites. Furthermore, based on coupling of the two nanomaterials, the composites could act as high sensitive Raman probe with limit of detection (LOD) reaching 1 × 10−12 M.

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Graphene Oxide/Gold Nanorod Nanocomposite for Stable Surface-Enhanced Raman Spectroscopy

Cited by 42 publications

References 58 publications

Sustained and Cost Effective Silver Substrate for Surface Enhanced Raman Spectroscopy Based Biosensing

Sustained and Cost Effective Silver Substrate for Surface Enhanced Raman Spectroscopy Based Biosensing

Polyadenine‐Modulated DNA Conformation Monitored by Surface‐Enhanced Raman Scattering (SERS) on Multibranched Gold Nanoparticles and Its Sensing Application

In‐Situ covalent synthesis of gold nanorods on GO surface as ultrasensitive Raman probe

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