Graphene oxide coated shell-core structured chitosan/PLLA nanofibrous scaffolds for wound dressing

Yang, Chengwei; Yan, Zhiyong; Lian, Yuan; Wang, Jiayan; Zhang, Kuihua

doi:10.1080/09205063.2019.1706149

Cited by 36 publications

(13 citation statements)

References 55 publications

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“…The outstanding physicochemical characteristics, antimicrobial activity, and biocompatibility of graphene, its derivatives, and nanocomposites make them promising candidates for a large variety of antimicrobial applications, presented in Figure 2. They could be summarized as follows [54][55][56]: support to disperse and stabilize various nanomaterials, such as metals, metal oxides, and polymers with high antibacterial efficiency due to the synergistic effect [55]; antibacterial agents for treatment of multidrug-resistant bacterial infections [34,57]; drug-delivery systems (based on the two-dimensional planar structure, large surface area, chemical and mechanical stability, and good biocompatibility) [34,58]; coatings for medical devices, membranes, and others, due to bread-spectrum antimicrobial activity [59][60][61][62][63][64]; creation of smart material surfaces (graphene materials with controllable wettability) [65]; biosensing and bioimaging (due to the ability to conjugate biomolecules and fluorescent dyes) [54], photothermal therapy (because of the high nearinfrared absorbance of the graphene) and gene therapy [54]; dentistry adhesives and dentin coatings [30,45]; endodontic (irrigants and intracanal medicaments; root canal disinfection) and the regenerative endodontics (support of bioactive molecules and enhancing the scaffold properties [66]; wound dressing and healing [33,40,[67][68][69][70][71]; sewage systems [72]; tissue repair, tissue and organ engineering (made possible by the ability of Gr materials to stimulate the growth of eukaryotic cells and to inhibit the microbial cells attachment and growth; 3D printing of 2D graphene to fabricate 3D structure for bone tissue scaffolds) [54]; antibacterial packaging [73]; water purification membranes…”

Section: Potential Applications Of Graphene Nanomaterialsmentioning

confidence: 99%

“…This scaffold is able to promote physiological electrical signal transmission for cell growth and reduces ROS oxidation, resulting in an improved wound regeneration as demonstrated at in vitro testing and in vivo experiments. Yang et al [ 70 ] developed GO-coated shell−core-structured chitosan/poly(lactic acid) (CS/PLLA) nanofibrous scaffolds for wound dressing. GO nanosheets are coated on the shell of CS/PLLA core without destroying the nanofiber structure.…”

Section: Antimicrobial Coatings Based On Graphene Materialsmentioning

confidence: 99%

“…The successfully coated GO nanosheets on CS/PLLA nanofibrous scaffolds significantly improve their hydrophilicity and antimicrobial activity toward Gram-negative ( E. coli ) and Gram-positive ( S. aureus ) bacteria. Rat wounds covered by GO-coated CS/PLLA nanofibrous scaffolds heal better than other groups on pathological sections [ 70 ]. A potential use for wound dressing is proposed also for Ag NPs/RGO nanocomposites, fabricated without additional dispersing agent [ 44 ].…”

Section: Antimicrobial Coatings Based On Graphene Materialsmentioning

confidence: 99%

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Antibiofouling Activity of Graphene Materials and Graphene-Based Antimicrobial Coatings

et al. 2021

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Microbial adhesion and biofilm formation is a common, nondesirable phenomenon at any living or nonliving material surface in contact with microbial species. Despite the enormous efforts made so far, the protection of material surfaces against microbial adhesion and biofilm formation remains a significant challenge. Deposition of antimicrobial coatings is one approach to mitigate the problem. Examples of such are those based on heparin, cationic polymers, antimicrobial peptides, drug-delivering systems, and other coatings, each one with its advantages and shortcomings. The increasing microbial resistance to the conventional antimicrobial treatments leads to an increasing necessity for new antimicrobial agents, among which is a variety of carbon nanomaterials. The current review paper presents the last 5 years’ progress in the development of graphene antimicrobial materials and graphene-based antimicrobial coatings that are among the most studied. Brief information about the significance of the biofouling, as well as the general mode of development and composition of microbial biofilms, are included. Preparation, antibacterial activity, and bactericidal mechanisms of new graphene materials, deposition techniques, characterization, and parameters influencing the biological activity of graphene-based coatings are focused upon. It is expected that this review will raise some ideas for perfecting the composition, structure, antimicrobial activity, and deposition techniques of graphene materials and coatings in order to provide better antimicrobial protection of medical devices.

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Section: Potential Applications Of Graphene Nanomaterialsmentioning

confidence: 99%

Section: Antimicrobial Coatings Based On Graphene Materialsmentioning

confidence: 99%

Section: Antimicrobial Coatings Based On Graphene Materialsmentioning

confidence: 99%

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Antibiofouling Activity of Graphene Materials and Graphene-Based Antimicrobial Coatings

et al. 2021

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“…In addition, they promoted the growth of pig iliac endothelial cells (PIECs). GO-coated chitosan/PLLA nanofibrous scaffolds possessed favorable wound healing in rats [168]. In a research work performed by Augustine et al, the wound healing membranes composed of core-shell fibers were produced by coaxial electrospinning.…”

Section: Application Of Pla-based Electrospun Fibers In Wound Healingmentioning

confidence: 99%

Bio-Based Electrospun Fibers for Wound Healing

Azimi

Maleki

Zavagna

et al. 2020

JFB

153

106

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Being designated to protect other tissues, skin is the first and largest human body organ to be injured and for this reason, it is accredited with a high capacity for self-repairing. However, in the case of profound lesions or large surface loss, the natural wound healing process may be ineffective or insufficient, leading to detrimental and painful conditions that require repair adjuvants and tissue substitutes. In addition to the conventional wound care options, biodegradable polymers, both synthetic and biologic origin, are gaining increased importance for their high biocompatibility, biodegradation, and bioactive properties, such as antimicrobial, immunomodulatory, cell proliferative, and angiogenic. To create a microenvironment suitable for the healing process, a key property is the ability of a polymer to be spun into submicrometric fibers (e.g., via electrospinning), since they mimic the fibrous extracellular matrix and can support neo- tissue growth. A number of biodegradable polymers used in the biomedical sector comply with the definition of bio-based polymers (known also as biopolymers), which are recently being used in other industrial sectors for reducing the material and energy impact on the environment, as they are derived from renewable biological resources. In this review, after a description of the fundamental concepts of wound healing, with emphasis on advanced wound dressings, the recent developments of bio-based natural and synthetic electrospun structures for efficient wound healing applications are highlighted and discussed. This review aims to improve awareness on the use of bio-based polymers in medical devices.

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“…However, by increasing the concentration of mGO up to 1 wt%, the proliferation of the HaCaT cells was prevented, and lower cytotoxicity was observed. In another in vivo study, rapid healing of dermal wounds was observed using a prototype wound dressing made of chitosan/L-polylactic acid/GO nanofibers [55].…”

Section: Clinical and Pre-clinical Studiesmentioning

confidence: 99%

Chitosan/Graphene Oxide Composite Films and Their Biomedical and Drug Delivery Applications: A Review

et al. 2021

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The healing of wounds is still a challenging clinical problem for which an efficient and fast treatment is needed. Therefore, recent studies have created a new generation of wound dressings that can accelerate the wound healing process with minimal side effects. Chitosan, a natural biopolymer, is an attractive candidate for preparing biocompatible dressings. The biodegradability, non-toxicity, and antibacterial activities of chitosan have made it a promising biopolymer for treating wounds. Graphene oxide has also been considered by researchers as a non-toxic, inexpensive, and biocompatible material for wound healing applications. This review paper discusses the potential use of chitosan/graphene oxide composite films and their application in wound dressing and drug delivery systems.

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Graphene oxide coated shell-core structured chitosan/PLLA nanofibrous scaffolds for wound dressing

Cited by 36 publications

References 55 publications

Antibiofouling Activity of Graphene Materials and Graphene-Based Antimicrobial Coatings

Antibiofouling Activity of Graphene Materials and Graphene-Based Antimicrobial Coatings

Bio-Based Electrospun Fibers for Wound Healing

Chitosan/Graphene Oxide Composite Films and Their Biomedical and Drug Delivery Applications: A Review

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