Graphene oxide-based NIR fluorescence probe with aggregation-induced emission property for lectins detection and liver cells targeting

Jiang, Tao; Tan, Haoqi; Sun, Yi; Wang, Jian; Hang, Yandi; Lu, Niannian; Yang, Ji; Qu, Xue; Hua, Jianli

doi:10.1016/j.snb.2017.10.163

Cited by 23 publications

(22 citation statements)

References 66 publications

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“…In addition to aptamer‐mediated targeting, these AIE‐integrated prior‐quenching or after‐activating strategies (and potentially many other types) should also work for other protein‐targeting designs. For example, combining carbohydrate–protein‐specific interactions and prior quenching has led to the sensitive detection of lectins in solutions and the selective targeting of overexpressed glycoprotein receptors on living liver cancer cells …”

Section: Detection Localization and Quantification Of Proteinsmentioning

confidence: 99%

“…For example, combining carbohydrate-protein-specific interactions and prior quenching has led to the sensitived etection of lectins in solutionsa nd the selectivet argeting of overexpressed glycoprotein receptors on living liver cancer cells. [24]…”

Section: In-solution Analysesmentioning

confidence: 99%

“…These probes have been used to quantify lectins in fetal bovine serum, [57] to detect toxins( cholera toxin), [83] to sense bacteria [56] and viruses (influenza virus A), [59] and to visualize carbohydrate receptors (transmembrane ASGP-R) on mammalian cells for cancer therapy. [24] Simple and quick AIE-based methods are of practical use as potentially sensitivet ests for pathogens. This is of significance in biomedical applications in view of the recent crisis of viruses and drug-resistants uperbugs.…”

Section: Protein-carbohydrate Interactionsmentioning

confidence: 99%

“…Fluorogenic AIE analysis was appliedt oq uantify enzymatic products through which the enzyme activity could be evaluated (Table 2, entries [22][23][24][25][26][27][28][29][30][31][32]. In these cases, natural biological substrates are favorably used, and thus, the study,i np rinciple, reveals the real activity of the enzymeo nt he natural substrate.…”

Section: Aiegens As Sensors To Monitor Enzyme Product Formationmentioning

confidence: 99%

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Fluorogenic Detection and Characterization of Proteins by Aggregation‐Induced Emission Methods

Xie

Wong

Chen

et al. 2019

Chemistry A European J

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Protein is one of the four most important biomacromolecules in living systems. The detection, quantification, localization, and characterization of proteins is essential for an understanding of biological fundamentals, as well as for the diagnostics and treatment of protein‐related diseases. By using intrinsic and extrinsic fluorescence, different techniques have been established to study proteins, many of which are now being routinely used in research laboratories and clinics. This review summarizes the applications of aggregation‐induced emission (AIE) fluorescence in protein science. In contrast to traditional fluorescent dyes, the activation of AIE dyes is mainly attributed to the restriction of intramolecular motions. This unique turn‐on mechanism of AIE dyes allows researchers to develop novel fluorogenic strategies for sensitive, selective, and reliable analysis of proteins. This review focuses on introducing AIE strategies for 1) detection, localization, and quantification of proteins; 2) probing polymer conformational transitions of proteins; 3) characterization of protein–ligand interactions; and 4) evaluation of enzyme activities. Perspectives and challenges with respect to this emerging field of protein characterization are offered.

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Section: Detection Localization and Quantification Of Proteinsmentioning

confidence: 99%

Section: In-solution Analysesmentioning

confidence: 99%

Section: Protein-carbohydrate Interactionsmentioning

confidence: 99%

Section: Aiegens As Sensors To Monitor Enzyme Product Formationmentioning

confidence: 99%

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Fluorogenic Detection and Characterization of Proteins by Aggregation‐Induced Emission Methods

Xie

Wong

Chen

et al. 2019

Chemistry A European J

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“…[3] To date, AIEgensh ave been used in av ariety of fields such as organic light-emitting diodes, [18][19][20][21][22][23] chemosensors [24][25][26][27][28][29][30] and biosensors. [31][32][33][34][35][36] Experimental results and theoretical analysis have consistently revealed that the restriction of intramolecular motions (RIM), which includes the restriction of intramolecularr otations (RIR) and the restriction of intramolecular vibration (RIV), is attributable to the mechanism of the AIE effect. [37][38][39] There are some other mechanismsw hich can be regarded as a proof of RIV.…”

Section: Introductionmentioning

confidence: 99%

Aggregation‐Induced Emission of Multiphenyl‐Substituted 1,3‐Butadiene Derivatives: Synthesis, Properties and Application

Zhang

Mao

et al. 2018

Chemistry A European J

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Organic functional materials, including conjugated molecules and fluorescent dyes, have been intensely developed in recent years because they can be applied in many fields, such as solar cells, biosensing and bioimaging, and medical adjuvant therapy. Organic functional materials with aggregation-induced emission or aggregation-enhanced emission (AIE/AEE) characteristics have increasingly attracted attention due to their high quantum efficiency in the aggregated or solid state. A large variety of AIE/AEE materials have been designed and applied during the exponential growth of research interest in the abovementioned fields. Multiphenyl-substituted 1,3-butadiene (MPB), as a core structure that includes tetraphenyl-1,3-butadiene, hexaphenyl-1,3-butadiene and their derivatives, show a typical AIE/AEE feature and can be potentially used in all the above-mentioned fields. This review summarizes the design principles, the corresponding syntheses, and the structure-property relationships of MPBs, as well as their excellent innovative functionalities and applications. This review will be useful for scientists conducting chemistry, materials, and biomedical research in AIE/AEE-related fields.

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Biomacromolecule‐Functionalized AIEgens for Advanced Biomedical Studies

Duan

et al. 2019

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The advances in bioinformatics and biomedicine have promoted the development of biomedical imaging and theranostic systems to respectively extend the endogenous biomarker imaging with high contrast and enhance the therapeutic effect with high efficiency. The emergence of biomacromolecule‐functionalized aggregation‐induced emitters (AIEgens), utilizing AIEgens, and biomacromolecules (nucleic acids, peptides, glycans, and lipids), displays specific targeting ability to cancer cell, improved biocompatibility, reduced toxicity, enhanced therapeutic effect, and so forth. This review summarizes the rational design of biomacromolecule‐functionalized AIEgens and their biomedical applications in recent ten years, including high‐resolution optical imaging of cell, tissue, and small animal model with low background; the biomarker detection for early diagnosis and prognosis; the delivery and monitoring of prodrugs; image‐guide photodynamic therapy and its combination with chemotherapy. Through illustrating their functional mechanisms and application, it is hoped that this review would open up a completely new train of research thought for attracted researchers in various fields.

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Graphene oxide-based NIR fluorescence probe with aggregation-induced emission property for lectins detection and liver cells targeting

Cited by 23 publications

References 66 publications

Fluorogenic Detection and Characterization of Proteins by Aggregation‐Induced Emission Methods

Fluorogenic Detection and Characterization of Proteins by Aggregation‐Induced Emission Methods

Aggregation‐Induced Emission of Multiphenyl‐Substituted 1,3‐Butadiene Derivatives: Synthesis, Properties and Application

Biomacromolecule‐Functionalized AIEgens for Advanced Biomedical Studies

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