Graphene oxide as a potential drug carrier – Chemical carrier activation, drug attachment and its enzymatic controlled release

Trusek-Hołownia, A.; Kijak, Edward; Granicka, Ludomira

doi:10.1016/j.msec.2020.111240

Cited by 28 publications

(15 citation statements)

References 49 publications

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“…Moreover, the large specific surface area of graphene can greatly improve cell adhesion, which likewise benefits the osteogenic activity ( Gao et al, 2017 ). Large specific surface area also facilitates the further functionalization of graphene, thus being able to impart better chemical activity and improve its hydrophilicity and dispersibility ( Trusek et al, 2020 ). The molecular size, content and uniformity of graphene will significantly affect the mechanical and electrical properties of the bone repair composite, and it is therefore important to determine the appropriate graphene content and ratio.…”

Section: Advantages Of Graphene In Bone Tissue Engineeringmentioning

confidence: 99%

Graphene and its Derivatives for Bone Tissue Engineering: In Vitro and In Vivo Evaluation of Graphene-Based Scaffolds, Membranes and Coatings

Jin

Liu

et al. 2021

Front. Bioeng. Biotechnol.

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Bone regeneration or replacement has been proved to be one of the most effective methods available for the treatment of bone defects caused by different musculoskeletal disorders. However, the great contradiction between the large demand for clinical therapies and the insufficiency and deficiency of natural bone grafts has led to an urgent need for the development of synthetic bone graft substitutes. Bone tissue engineering has shown great potential in the construction of desired bone grafts, despite the many challenges that remain to be faced before safe and reliable clinical applications can be achieved. Graphene, with outstanding physical, chemical and biological properties, is considered a highly promising material for ideal bone regeneration and has attracted broad attention. In this review, we provide an introduction to the properties of graphene and its derivatives. In addition, based on the analysis of bone regeneration processes, interesting findings of graphene-based materials in bone regenerative medicine are analyzed, with special emphasis on their applications as scaffolds, membranes, and coatings in bone tissue engineering. Finally, the advantages, challenges, and future prospects of their application in bone regenerative medicine are discussed.

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Section: Advantages Of Graphene In Bone Tissue Engineeringmentioning

confidence: 99%

Graphene and its Derivatives for Bone Tissue Engineering: In Vitro and In Vivo Evaluation of Graphene-Based Scaffolds, Membranes and Coatings

Jin

Liu

et al. 2021

Front. Bioeng. Biotechnol.

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“…GO with the peptide linker (Gly-Gly-Leu) was prepared according to the scheme described previously [31,33]. Divinyl sulfone is a known activator of hydroxyl groups in the literature [34,35].…”

Section: Go-amox Complex Preparationmentioning

confidence: 99%

“…Cytotoxic effects of an AMOX, GO, GO-AMOX complex, and GO-AMOX + BROM solution on the cell line of mice fibrosarcoma WEHI 164 were observed using propidium iodide [39,40]. Cells cultivation and viability were performed under conditions described previously [31].…”

Section: Cytotoxic Effects Of Prepared Drug Carriersmentioning

confidence: 99%

“…Although the cytotoxic effect of GO flakes has been investigated previously [31], cytotoxicity of the prepared carriers with AMOX was determined-Figure 8. The cells cultured in the absence of additions served as a control served, for which a value of 94.1% of viable cells was obtained.…”

Section: Cytotoxic Effects Of Prepared Drug Carriesmentioning

confidence: 99%

“…Although the cytotoxic effect of GO flakes has been investigated previously [31], cytotoxicity of the prepared carriers with AMOX was determined-Figure 8. AMOX and BROM at the concentration 0.2 mg/mL.…”

Section: Cytotoxic Effects Of Prepared Drug Carriesmentioning

confidence: 99%

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Drug Carriers Based on Graphene Oxide and Hydrogel: Opportunities and Challenges in Infection Control Tested by Amoxicillin Release

Trusek-Hołownia

Kijak

2021

Materials

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Graphene oxide (GO) was proposed as an efficient carrier of antibiotics. The model drug, amoxicillin (AMOX), was attached to GO using a peptide linker (Leu-Leu-Gly). GO-AMOX was dispersed in a hydrogel to which the enzyme responsible for releasing AMOX from GO was also added. The drug molecules were released by enzymatic hydrolysis of the peptide bond in the linker. As the selected enzyme, bromelain, a plant enzyme, was used. The antibacterial nature of the carrier was determined by its ability to inhibit the growth of the Enterococcus faecalis strain, which is one of the bacterial species responsible for periodontal and root canal diseases. The prepared carrier contained only biocompatible substances, and the confirmation of its lack of cytotoxicity was verified based on the mouse fibrosarcoma cell line WEHI 164. The proposed type of preparation, as a universal carrier of many different antibiotic molecules, can be considered as a suitable solution in the treatment of inflammation in dentistry.

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Science and Technology of Nanomaterials: Introduction

Thomas

Pothen

2022

Nanotechnology for Environmental Remediation

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Graphene oxide as a potential drug carrier – Chemical carrier activation, drug attachment and its enzymatic controlled release

Cited by 28 publications

References 49 publications

Graphene and its Derivatives for Bone Tissue Engineering: In Vitro and In Vivo Evaluation of Graphene-Based Scaffolds, Membranes and Coatings

Graphene and its Derivatives for Bone Tissue Engineering: In Vitro and In Vivo Evaluation of Graphene-Based Scaffolds, Membranes and Coatings

Drug Carriers Based on Graphene Oxide and Hydrogel: Opportunities and Challenges in Infection Control Tested by Amoxicillin Release

Science and Technology of Nanomaterials: Introduction

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