Graphene oxide and carbon dots as broad-spectrum antimicrobial agents – a minireview

Anand, Anisha; Unnikrishnan, Binesh; Wei, Shih-Chun; Chou, C. Perry; Zhang, Lizhi; Huang, Chih‐Ching

doi:10.1039/c8nh00174j

Cited by 236 publications

(170 citation statements)

References 157 publications

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“…The factors influence to antibacterial effect come the medium culture condition (Mueller-Hinton Broth) or the purity of GO [55]. In contrast, other reports showed that GO had a bactericidal effect [10,56]. Previously, a three-step antibacterial mechanism of graphene-based materials was proposed: initial cell deposition, membrane stress caused by direct contact and oxidation stress on glutathione, which serve as a redox mediator in bacteria [7].…”

Section: Discussionmentioning

confidence: 99%

Synergistic Antibacterial Activity of Silver-Loaded Graphene Oxide towards Staphylococcus Aureus and Escherichia Coli

et al. 2020

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In this study, the physicochemical and surface properties of the GO–Ag composite promote a synergistic antibacterial effect towards both Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. Aureus) bacteria. GO–Ag NPs have a better bactericidal effect on E. coli (73%) and S. Aureus (98.5%) than pristine samples (pure Ag or GO). Transmission electron microscopy (TEM) confirms that the GO layers folded entire bacteria by attaching to the membrane through functional groups, while the Ag NPs penetrated the inner cell, thus damaging the cell membrane and leading to cell death. Cyclic voltammetry (CV) tests showed significant redox activity in GO–Ag NPs, enabling good catalytic performance towards H2O2 reduction. Strong reactive oxygen species (ROS) in GO–Ag NPs suggests that ROS might be associated with bactericidal activity. Therefore, the synergy between the physicochemical effect and ROS production of this material is proposed as the mechanism of its antibacterial activity.

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Section: Discussionmentioning

confidence: 99%

Synergistic Antibacterial Activity of Silver-Loaded Graphene Oxide towards Staphylococcus Aureus and Escherichia Coli

et al. 2020

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“…In previous research, the CDs, including carbon quantum dots (CQDs; sp 2 /sp 3 carbon) and graphene quantum dots (GQDs; sp 2 carbon), can be functionalized with different molecules or other functional groups for labelling, sensing, tissue imaging, and antibacterial applications. 20 Hence, the determination of the functional groups of the CDs is very important for the following applications. In this research, the functional groups of the negative-charge CDs were measured by using the FT-IR instrument and the data was as shown in Fig.…”

Section: Characterization Of the Cdsmentioning

confidence: 99%

Microwave assisted synthesis of negative-charge carbon dots with potential antibacterial activity against multi-drug resistant bacteria

et al. 2020

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“…Compared with reported nanomaterials, carbon nanomaterials (e.g. fullerenes, carbon nanotubes, graphenes, carbon quantum dots) with broad spectral coverage and other superior material properties have attracted wider attention in antibacterial and related applications in recent years [8][9][10] . Carbon quantum dots (CQDs), especially hetero-element doped CQDs with particle size of less than 10 nm, stand out in the eld of antibacterial research due to their advantageous properties including nontoxic nature, photostability, versatility in surface functionality for desired microbial adhesion and interactions, and their production from abundant and inexpensive precursors for extremely broad and low to ultralow cost applications [11][12][13][14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

Quaternized carbon quantum dots with broad-spectrum antibacterial activity for treatment of wounds infected with mixed bacteria

Zhao

Wang

et al. 2020

Preprint

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Quaternized carbon quantum dots (qCQDs) with broad-spectrum antibacterial activity were synthesized by a simple green “one-pot” method using dimethyl diallyl ammonium chloride and glucose as reaction precursors. The qCQDs showed satisfactory antibacterial activity against both gram-positive and gram-negative bacteria. In rat models of wounds infected with mixed bacteria, qCQDs obviously restored the weight of rats, significantly reduced the death of rats from severe infection, and promoted the recovery and healing of infected wounds. Biosafety tests confirmed that qCQDs had no obvious toxic and side effects during the testing stage. The analysis of quantitative proteomics revealed that qCQDs mainly acted on the ribosomal proteins of gram-positive bacteria and significantly down-regulated the metabolization-related proteins of gram-negative bacteria. Real-time quantitative PCR verified the expression levels of genes corresponding to the proteins with significant differences expressed by the two species of bacteria after treated with qCQDs. The variation trend of the detected genes was consistent with the results of proteomics, meaning that qCQDs played the antibacterial effect on bacteria with a new antibacterial mechanism.

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Graphene oxide and carbon dots as broad-spectrum antimicrobial agents – a minireview

Abstract: Complex antibacterial mechanisms of graphene oxide and carbon dots.

Cited by 236 publications

References 157 publications

Synergistic Antibacterial Activity of Silver-Loaded Graphene Oxide towards Staphylococcus Aureus and Escherichia Coli

Synergistic Antibacterial Activity of Silver-Loaded Graphene Oxide towards Staphylococcus Aureus and Escherichia Coli

Microwave assisted synthesis of negative-charge carbon dots with potential antibacterial activity against multi-drug resistant bacteria

Quaternized carbon quantum dots with broad-spectrum antibacterial activity for treatment of wounds infected with mixed bacteria

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