Graphene modified glassy carbon sensor for the determination of aspirin metabolites in human biological samples

A novel, facile fabrication, based on electrochemically reduced graphene oxide (ErGO), grafted with Pt nanoparticles and Nafion hybrid nano‐composite (ErGO‐Pt/Nafion) on the surface of edge plane pyrolytic graphite (EPPG) has been reported. The fabricated sensor has been used for the sensitive and selective determination of efavirenz (EFZ), a well‐known drug for HIV infections. The ErGO‐Pt/Nafion film was characterized by Field Emission Scanning Electron Microscopy (FE‐SEM), Energy‐dispersive X‐ray spectrometry (EDS) and Electrochemical Impedance Spectroscopy (EIS). The experimental results reveal that the modified sensor displays an excellent electrocatalytic activity towards the oxidation of EFZ and exhibits a large linear dynamic relationship in the range of 0.05 μM to 150 μM, with a detection limit of 1.8 nM. Practical utility of the developed sensor has been demonstrated by determining the EFZ in biological fluids and pharmaceutical samples and a low detection limit with high sensitivity observed makes it valuable for the clinical diagnosis.

show abstract

“…having R 2 as 0.9878 and slope value (>0.5) further confirmed the adsorption controlled oxidation of EFZ .…”

Section: Resultsmentioning

confidence: 99%

A Novel Hybrid Nano‐composite Grafted Electrochemically Reduced Graphene Oxide Based Sensor for Sensitive Determination of Efavirenz

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…ASA itself is polar and can cross the skin without difficulty. Once ingested, ASA is rapidly hydrolyzed in the body to produce salicylic acid (SA), which is the compound that is primarily responsible for the pharmacological activity and it is further metabolized to gentisic acid, salicyluric acid and other conjugates [2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous voltammetric determination of acetylsalicylic acid, caffeine and paracetamol in pharmaceutical formulations using screen‐printed carbon electrode

2023

View full text Add to dashboard Cite

Electrochemical oxidation of Paracetamol (PAR), Acetylsalicylic acid (ASA) and Caffeine (CAF) was investigated employing square wave stripping voltammetry (SWSV) using screen–printed carbon electrodes (SPCE). Determinations were performed in 0.1 mol L−1 BR buffer (pH 2.0) without accumulation step. SWV were obtained by scanning the potential from 0.00 to 1.40 V employing a scan increment of 4 mV, pulse amplitude 25 mV and frequency of 25 Hz. PAR, ASA and CAF presents oxidation signals at 0.45, 1.03 and 1.32 V. The detection limits were 1.2, 1.7 and 1.7 mg L−1, respectively. The method was applied in the PAR‐ASA‐CAF determination on pharmaceutical formulations.

show abstract

“…1,2 Substantial efforts have been made to study its electrochemical properties in the last era of scientic research, where global innovations in using graphene as a potential electrode material and its application in sensing and energy related devices have been widely documented. [2][3][4][5][6][7] Since, graphene has already performed very well in various technological and application based elds, like in the fabrication of energy storage devices, 8,9 its use as surface modication material [5][6][7] and its execution as a substrate for sensing and energy production, 10,11 the next stage of graphene research lies in tailoring its exceptional and superior properties, by introducing defects using ion beams, chemical modication, or by means of doping. 3,12 Controlled insertion of defects in graphene can be achieved in order to induce modication in its chemical, physical and mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Structural and electrochemical characterization of carbon ion beam irradiated reduced graphene oxide and its application in voltammetric determination of norepinephrine

2015

Self Cite

View full text Add to dashboard Cite

Irradiation of reduced graphene oxide (rGO) sheets using 50 MeV C 4+ ion beam has been implemented to create disorders. The changes in the charge transfer resistance (R CT ) and structural variations in rGO upon irradiation have been studied using electrochemical impedance spectroscopy (EIS), Raman spectroscopy and field emission scanning electron microscopy (FE-SEM). Irradiation of rGO with 50 MeV C 4+ ion beam resulted in three fold decreased charge transfer resistance (R CT 32.91 Ω) in comparison to 93.42 Ω corresponding to pristine rGO. Electrochemical properties of irradiated rGO have been further investigated by developing an irradiated rGO modified glassy carbon electrode (GCE) for the analysis of norepinephrine (NE). Voltammetric experiments showed that irradiated rGO modified GCE (Irradiated rGO/GCE) exhibited superior response towards NE oxidation in comparison to both the pristine rGO/GCE and bare GCE. Thus, NE has been quantified using Irradiated rGO/GCE in a linear concentration range of 1 -200 µM with a detection limit of 50 nM.Detection sensitivities corresponding to bare, pristine rGO and irradiated rGO modified GCE were 0.0173, 0.1335 and 0.769 µA µM -1 respectively, demonstrating substantial improvement in sensing and electrocatalytic behaviour of rGO on exposure to ion beam. To ensure the analytical applicability of the fabricated sensor it has been successfully applied for the estimation of norepinephrine (NE) in injection, human urine and serum samples and recovery >93 % with R.S.D < 3.5 % were achieved.

show abstract

Graphene modified glassy carbon sensor for the determination of aspirin metabolites in human biological samples

Cited by 19 publications

References 43 publications

A Novel Hybrid Nano‐composite Grafted Electrochemically Reduced Graphene Oxide Based Sensor for Sensitive Determination of Efavirenz

A Novel Hybrid Nano‐composite Grafted Electrochemically Reduced Graphene Oxide Based Sensor for Sensitive Determination of Efavirenz

Simultaneous voltammetric determination of acetylsalicylic acid, caffeine and paracetamol in pharmaceutical formulations using screen‐printed carbon electrode

Structural and electrochemical characterization of carbon ion beam irradiated reduced graphene oxide and its application in voltammetric determination of norepinephrine

Contact Info

Product

Resources

About