Simultaneous voltammetric determination of acetylsalicylic acid, caffeine and paracetamol in pharmaceutical formulations using screen‐printed carbon electrode

Abstract

Electrochemical oxidation of Paracetamol (PAR), Acetylsalicylic acid (ASA) and Caffeine (CAF) was investigated employing square wave stripping voltammetry (SWSV) using screen–printed carbon electrodes (SPCE). Determinations were performed in 0.1 mol L−1 BR buffer (pH 2.0) without accumulation step. SWV were obtained by scanning the potential from 0.00 to 1.40 V employing a scan increment of 4 mV, pulse amplitude 25 mV and frequency of 25 Hz. PAR, ASA and CAF presents oxidation signals at 0.45, 1.03 and 1.32 V. The detection limits were 1.2, 1.7 and 1.7 mg L−1, respectively. The method was applied in the PAR‐ASA‐CAF determination on pharmaceutical formulations.

A new microconductometric sensor based on a PVC membrane including an o‐COSAN ion‐pair complex for the detection of caffeine

“…The inter-sensor reproducibility obtained for five sensors is 8 %. When comparing the analytical performance of this conductometric sensor to that of the previously published sensors, the detection limit is lower than that of the potentiometric sensor [1] and of the voltammetric sensor on bare BDD [19]. Nevertheless, the voltammetric detection of caffeine in the presence of nanomaterials leads to a lower detection limit, in the range of nM [22][23][24][25][26][27].…”

“…Several works were carried out on this type of bare electrode [17,18]. A comparison between the electrochemical detection of caffeine on BDD and on screen-printed carbon electrodes (SPCE) was carried out [19], the detection limit obtained on BDD (0.4 mg/L) was lower than that obtained on SPCE (1.7 mg/mL) in the same conditions. To decrease the detection limits, the modification of electrodes with different types of nanomaterials was carried out.…”