Graphene field effect transistors for in vitro and ex vivo recordings

Kireev, Dmitry; Zadorozhnyi, Ihor; Qiu, Tianyu; Sarik, Dario; Brings, Fabian; Wu, Tianru; Seyock, Silke; Maybeck, Vanessa; Lottner, Martin; Blaschke, Benno M.; Garrido, José Antonio; Xie, Xiaoming; Vitusevich, S. А.; Wolfrum, Bernhard; Offenhuusser, Andreas

doi:10.1109/tnano.2016.2639028

Cited by 23 publications

(32 citation statements)

References 44 publications

(64 reference statements)

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“…Small area graphene can be prepared using mechanical exfoliation, which is tedious and time-consuming. CVD allows growing high-quality graphene over large areas at either high temperatures of over 1,000°C or on specific substrates in a specific gas mixture, but is incompatible with polymer materials (Kireev et al, 2016 ). Significant efforts have been made in recent years to transfer CVD graphene from rigid substrates onto soft substrates.…”

Section: Electrode Materialsmentioning

confidence: 99%

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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To date, a wide variety of neural tissue implants have been developed for neurophysiology recording from living tissues. An ideal neural implant should minimize the damage to the tissue and perform reliably and accurately for long periods of time. Therefore, the materials utilized to fabricate the neural recording implants become a critical factor. The materials of these devices could be classified into two broad categories: electrode materials as well as packaging and substrate materials. In this review, inorganic (metals and semiconductors), organic (conducting polymers), and carbon-based (graphene and carbon nanostructures) electrode materials are reviewed individually in terms of various neural recording devices that are reported in recent years. Properties of these materials, including electrical properties, mechanical properties, stability, biodegradability/bioresorbability, biocompatibility, and optical properties, and their critical importance to neural recording quality and device capabilities, are discussed. For the packaging and substrate materials, different material properties are desired for the chronic implantation of devices in the complex environment of the body, such as biocompatibility and moisture and gas hermeticity. This review summarizes common solid and soft packaging materials used in a variety of neural interface electrode designs, as well as their packaging performances. Besides, several biopolymers typically applied over the electrode package to reinforce the mechanical rigidity of devices during insertion, or to reduce the immune response and inflammation at the device-tissue interfaces are highlighted. Finally, a benchmark analysis of the discussed materials and an outlook of the future research trends are concluded.

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Section: Electrode Materialsmentioning

confidence: 99%

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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“…Many types of commercially available polyimides have been widely used for biosensor encapsulation and as substrates for implantable devices due to their high flexibility, electrical resistivity, thermal and chemical stability, and biocompatibility [ 24 , 25 , 26 ]. In addition to these benefits, photo-definable polyimides are easy to pattern using photo-lithography, which facilitates biosensor or bioelectronics fabrication [ 25 , 26 , 27 , 28 ]. Therefore, in this study, photo-definable polyimide (HD-8820, HD MicroSystems, Parlin, NJ, USA) served as both structural substrates and insulation layers that resulted in simplified fabrication and cost savings.…”

Section: Methodsmentioning

confidence: 99%

Development of a Dental Implantable Temperature Sensor for Real-Time Diagnosis of Infectious Disease

Kim

Stafford

Beauchamp

et al. 2020

Sensors

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Implantable sensors capable of real-time measurements are powerful tools to diagnose disease and maintain health by providing continuous or regular biometric monitoring. In this paper, we present a dental implantable temperature sensor that can send early warning signals in real time before the implant fails. Using a microfabrication process on a flexible polyimide film, we successfully fabricated a multi-channel temperature sensor that can be wrapped around a dental implant abutment wing. In addition, the feasibility, durability, and implantability of the sensor were investigated. First, high linearity and repeatability between electrical resistance and temperature confirmed the feasibility of the sensor with a temperature coefficient of resistance (TCR) value of 3.33 × 10–3/°C between 20 and 100 °C. Second, constant TCR values and robust optical images without damage validated sufficient thermal, chemical, and mechanical durability in the sensor’s performance and structures. Lastly, the elastic response of the sensor’s flexible substrate film to thermal and humidity variations, simulating in the oral environment, suggested its successful long-term implantability. Based on these findings, we have successfully developed a polymer-based flexible temperature sensor for dental implant systems.

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“…As previously mentioned, an advantage of gSGFETs (if compared to standard silicon transistors) is the fact that they can be fabricated onto flexible substrates without any loss in transconductance, this peculiarity making them interesting tools for ex vivo and in vitro cardio-electrophysiology applications, as demonstrated by Kireev et al 107 The same group also demonstrated the possibility of using gSGFET arrays for neural in vitro recording, and proposed a new passivation approach called "feedline follower", which consists of passivating only the metallic feedlines instead of the whole surface of the array, in order to improve the cell/ graphene coupling by reducing the gap distance between the cell and the gate. 108 In Fig.…”

Section: Sgofetsmentioning

confidence: 99%

Interfacing cells with organic transistors: a review ofin vitroandin vivoapplications

2021

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Graphene field effect transistors for in vitro and ex vivo recordings

Cited by 23 publications

References 44 publications

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Development of a Dental Implantable Temperature Sensor for Real-Time Diagnosis of Infectious Disease

Interfacing cells with organic transistors: a review ofin vitroandin vivoapplications

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