Graphene family nanomaterials for application in cancer combination photothermal therapy

Melo‐Diogo, Duarte de; Lima‐Sousa, Rita; Alves, Cátia G.; Correia, Ilídio J.

doi:10.1039/c9bm00577c

Cited by 101 publications

(65 citation statements)

References 100 publications

(198 reference statements)

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“…The terms GBMs or graphene family nanomaterial (GFNs) includes GR and its derivatives, such as GO, rGO, GR/GO dots (GD/GOD), GR nano-onions, and GR nano-ribbons, as well as fullerenes, and CNTs, see Figure 2 [10,11]. groups, while at the edges of the flakes there are carboxylic groups [18,22,23]. This composition is a reason for the aforementioned hydrophilicity, the good aqueous dispersity, and the excellent ability to easily cross cell membranes.…”

Section: Graphene-based Materialsmentioning

confidence: 99%

“…The GO flakes consist of a typical graphenic planar structure, composed of sp 2 carbon atoms that is disrupted by the presence of carbon atoms in the sp 3 hybridization state. While on the planar surface, there are mainly hydroxyl and epoxy functional groups, while at the edges of the flakes there are carboxylic groups [18,22,23]. This composition is a reason for the aforementioned hydrophilicity, the good aqueous dispersity, and the excellent ability to easily cross cell membranes.…”

Section: Graphene-based Materialsmentioning

confidence: 99%

“…Due to this fact, alternatives have been studied, such as organic acids, amino acids, proteins, sugars, microorganisms, plant extracts, and antioxidants, which are called "green reducing agents" [29]. Another method of reduction is thermal, solothermal, electrochemical, microwave, and photoreduction [11,19,23]. It was found in some instances that not all functional groups were eliminated during the reduction, and some of them remained preserved on the rGO basal plane, e.g., -OH, -C-O-C-, -CO, and -COOH.…”

Section: Graphene-based Materialsmentioning

confidence: 99%

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Graphenic Materials for Biomedical Applications

2019

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Graphene-based nanomaterials have been intensively studied for their properties, modifications, and application potential. Biomedical applications are one of the main directions of research in this field. This review summarizes the research results which were obtained in the last two years (2017-2019), especially those related to drug/gene/protein delivery systems and materials with antimicrobial properties. Due to the large number of studies in the area of carbon nanomaterials, attention here is focused only on 2D structures, i.e. graphene, graphene oxide, and reduced graphene oxide.

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Section: Graphene-based Materialsmentioning

confidence: 99%

Section: Graphene-based Materialsmentioning

confidence: 99%

Section: Graphene-based Materialsmentioning

confidence: 99%

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Graphenic Materials for Biomedical Applications

2019

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“…Intact removal of hydrogel-forming MAPs may also facilitate targeted, minimally invasive, photothermal (PTT) therapy of nonmelanoma skin cancers. In PTT, heating the tissue to be destroyed to ≥ 43°C yields protein denaturation and disruption of the cellular membrane, causing ablation of tumour tissues [6][7][8]. We have recently loaded hydrogel-forming MAPs with plasmonic gold nanorods.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the clinical impact of repeat application of hydrogel-forming microneedle array patches

Al-Kasasbeh

Brady

Courtenay

et al. 2020

Drug Deliv. and Transl. Res.

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Hydrogel-forming microneedle array patches (MAPs) have been proposed as viable clinical tools for patient monitoring purposes, providing an alternative to traditional methods of sample acquisition, such as venepuncture and intradermal sampling. They are also undergoing investigation in the management of non-melanoma skin cancers. In contrast to drug or vaccine delivery, when only a small number of MAP applications would be required, hydrogel MAPs utilised for sampling purposes or for tumour eradication would necessitate regular, repeat applications. Therefore, the current study was designed to address one of the key translational aspects of MAP development, namely patient safety. We demonstrate, for the first time in human volunteers, that repeat MAP application and wear does not lead to prolonged skin reactions or prolonged disruption of skin barrier function. Importantly, concentrations of specific systemic biomarkers of inflammation (C-reactive protein (CRP); tumour necrosis factor-α (TNF-α)); infection (interleukin-1β (IL-1β); allergy (immunoglobulin E (IgE)) and immunity (immunoglobulin G (IgG)) were all recorded over the course of this fixed study period. No biomarker concentrations above the normal, documented adult ranges were recorded over the course of the study, indicating that no systemic reactions had been initiated in volunteers. Building upon the results of this study, which serve to highlight the safety of our hydrogel MAP, we are actively working towards CE marking of our MAP technology as a medical device.

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“…Up to now, both inorganic and organic nanomaterials have been used as PTAs for PTT studies [4][5][6][7] . Organic PTAs can be divided into two categories in view of the structure: one is solid organic PTAs such as carbon nanomaterials [8][9][10] , conducting polymer nanoparticles [11][12][13] , black phosphorus 14,15 , nanodots 16 , and so on, the other ones are hollow organic PTAs like vesicles 17,18 . Among them, vesicular PTAs have received considerable attention due to their superior lightharvesting ability resulting from multiple reflections of incident light in hollow compartments of vesicles 19,20 , and prominent versatility by trapping hydrophilic functional units in their hollow cavities as well as hydrophobic units in the membrane.…”

mentioning

confidence: 99%

In situ supramolecular polymerization-enhanced self-assembly of polymer vesicles for highly efficient photothermal therapy

et al. 2020

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Vesicular photothermal therapy agents (PTAs) are highly desirable in photothermal therapy (PTT) for their excellent light-harvesting ability and versatile hollow compartments. However, up to now, the reported vesicular PTAs are generally self-assembled from small molecules like liposomes, and polymer vesicles have seldom been used as PTAs due to the unsatisfactory photothermal conversion efficiency resulting from the irregular packing of chromophores in the vesicle membranes. Here we report a nano-sized polymer vesicle from hyperbranched polyporphyrins with favorable photothermal stability and extraordinarily high photothermal efficiency (44.1%), showing great potential in imaging-guided PTT for tumors through in vitro and in vivo experiments. These excellent properties are attributed to the in situ supramolecular polymerization of porphyrin units inside the vesicle membrane into well-organized 1D monofilaments driven by π-π stacking. We believe the supramolecular polymerization-enhanced self-assembly process reported here will shed a new light on the design of supramolecular materials with new structures and functions.

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Graphene family nanomaterials for application in cancer combination photothermal therapy

Abstract: Graphene family nanomaterials mediated photothermal therapy can improve the efficacy of chemo-, photodynamic-, gene-, radio-, and immuno-therapies.

Cited by 101 publications

References 100 publications

Graphenic Materials for Biomedical Applications

Graphenic Materials for Biomedical Applications

Evaluation of the clinical impact of repeat application of hydrogel-forming microneedle array patches

In situ supramolecular polymerization-enhanced self-assembly of polymer vesicles for highly efficient photothermal therapy

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