Graphene based sensors and biosensors

Justino, Celine I.L.; Gomes, Ana R.; Freitas, Ana C.; Duarte, Armando C.; Rocha-Santos, Teresa

doi:10.1016/j.trac.2017.04.003

Cited by 453 publications

(217 citation statements)

References 106 publications

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“…In addition, once functionalized with biomolecules like polysaccharides [41], proteins [42], etc. or other biological systems graphene can be integrated for developing new applications in biomedicine and bio-nanotechnology such as biosensors [43], biocatalysis [44], biofuel cells [45], etc.…”

Section: Graphene and Graphene Oxidementioning

confidence: 99%

Graphene Nanocomposites Studied by Raman Spectroscopy

Bîru¹,

Iovu²

2018

Raman Spectroscopy

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The goal of this chapter is to provide a general introduction about graphene nanocomposites studied by Raman spectroscopy. The chapter will therefore begin with a brief description of the major Raman bands of carbon allotropes. In the following chapter a concise comparison between single walled carbon nanotubes (SWCNTs), multi-walled carbon nanotubes (MWCNTs), fullerenes and graphene is exposed. The characteristic features in Raman spectra of carbon allotropes, namely the intense signals D and G are investigated. In particular, the chapter will outline the Raman spectrum of graphene and different types of graphene oxide. The last part of the chapter is devoted to graphene nanocomposites.

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Section: Graphene and Graphene Oxidementioning

confidence: 99%

Graphene Nanocomposites Studied by Raman Spectroscopy

Bîru¹,

Iovu²

2018

Raman Spectroscopy

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“…Therefore, many organic synthesis principles can be employed with functional supramolecular nanoassemblies of π‐conjugated molecules to realize responsiveness to various stimuli. For example, the combination of GO or RGO sheets with functional polymers or various metal nanoparticles can enhance the analytical response of biosensors, improving their sensitivity, limit of detection, and reproducibility …”

Section: Attributes Of Graphene and Its Derivatives For Mirna Detectionmentioning

confidence: 99%

Progress in miRNA Detection Using Graphene Material–Based Biosensors

Zhang

Miao

Sun

et al. 2019

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MicroRNAs (miRNAs) are short, endogenous, noncoding RNAs that play critical roles in physiologic and pathologic processes and are vital biomarkers for several disease diagnostics and therapeutics. Therefore, rapid, low‐cost, sensitive, and selective detection of miRNAs is of paramount importance and has aroused increasing attention in the field of medical research. Among the various reported miRNA sensors, devices based on graphene and its derivatives, which form functional supramolecular nanoassemblies of π‐conjugated molecules, have been revealed to have great potential due to their extraordinary electrical, chemical, optical, mechanical, and structural properties. This Review critically and comprehensively summarizes the recent progress in miRNA detection based on graphene and its derivative materials, with an emphasis on i) the underlying working principles of these types of sensors, and the unique roles and advantages of graphene materials; ii) state‐of‐the‐art protocols recently developed for high‐performance miRNA sensing, including representative examples; and iii) perspectives and current challenges for graphene sensors. This Review intends to provide readers with a deep understanding of the design and future of miRNA detection devices.

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“…A graphene-based material is promising as a candidate platform for biosensors because of its high surface-area-to-volume ratio, excellent conductivity, small band gap favorable for sensitive electrical and electrochemical abilities (Zang et al, 2017;García et al, 2018;Liu et al, 2018), and tunable optical properties for absorbance and reflectance such as plasmonics and fluorescence (Kim et al, 2016;Justino et al, 2017;Suvarnaphaet and Pechprasarn, 2017). In general, laser ablation enables the removal of a material without the use of lithographic masks, and other predetermined patterns commonly used in the fabrication of biosensing devices (Liébana et al, 2016;Verma et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Thermally stable and uniform DNA amplification with picosecond laser ablated graphene rapid thermal cycling device

Chen

Chang

et al. 2019

Biosensors and Bioelectronics

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Rapid thermal cycling (RTC) in an on-chip device can perform DNA amplification in vitro through precise thermal control at each step of the polymerase chain reaction (PCR). This study reports a straightforward fabrication technique for patterning an on-chip graphene-based device with hole arrays, in which the mechanism of surface structures can achieve stable and uniform thermal control for the amplification of DNA fragments. A thin-film based PCR device was fabricated using picosecond laser (PS-laser) ablation of the multilayer graphene (MLG). Under the optimal fluence of 4.72 J/cm 2 with a pulse overlap of 66%, the MLG can be patterned with arrays of 250 μm 2 hole surface structures. A 354-bp DNA fragment of VP1, an effective marker for diagnosing the BK virus, was amplified on an on-chip device in less than 60 min. A thin-film electrode with the aforementioned MLG as the heater was demonstrated to significantly enhance temperature stability for each stage of the thermal cycle. The temperature control of the heater was performed by means of a developed programmable PCR apparatus. Our results demonstrated that the proposed integration of a graphene-based device and a laser-pulse ablation process to form a thin-film PCR device has cost benefits in a small-volume reagent and holds great promise for practical medical use of DNA amplification.

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Graphene based sensors and biosensors

Cited by 453 publications

References 106 publications

Graphene Nanocomposites Studied by Raman Spectroscopy

Graphene Nanocomposites Studied by Raman Spectroscopy

Progress in miRNA Detection Using Graphene Material–Based Biosensors

Thermally stable and uniform DNA amplification with picosecond laser ablated graphene rapid thermal cycling device

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