Graphene based materials for biomedical applications

Yang, Yuqi; Asiri, Abdullah M.; Tang, Zhixiang; Du, Dan; Lin, Yuehe

doi:10.1016/j.mattod.2013.09.004

Cited by 582 publications

(301 citation statements)

References 83 publications

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“…5,6 Carbon allotropes, like graphene oxide (GO), fullerenes, carbon nanotubes, etc., have been explored for cellular imaging, tissue engineering, intercalation materials, drug delivery biomaterials and biosensors. [7][8][9][10][11] For biosensor fabrication, the presence of available functional groups (e.g. hydroxyl, epoxide, carbonyl, carboxyl, etc.)…”

Section: Introductionmentioning

confidence: 99%

Reduced graphene oxide–titania based platform for label-free biosensor

et al. 2014

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A label-free biosensor has been fabricated using a reduced graphene oxide (RGO) and anatase titania (antTiO 2 ) nanocomposite, electrophoretically deposited onto an indium tin oxide coated glass substrate. The RGO-ant-TiO 2 nanocomposite has been functionalized with protein (horseradish peroxidase) conjugated antibodies for the specific recognition and detection of Vibrio cholerae. The presence of Ab-Vc on the RGO-ant-TiO 2 nanocomposite has been confirmed using electron microscopy, Fourier transform infrared spectroscopy and electrochemical techniques. Electrochemical studies relating to the fabricated Ab-Vc/RGO-ant-TiO 2 /ITO immunoelectrode have been conducted to investigate the binding kinetics.This immunosensor exhibits improved biosensing properties in the detection of Vibrio cholerae, with a sensitivity of 18.17 Â 10 6 F mol À1 L À1 m À2 in the detection range of 0.12-5.4 nmol L À1 , and a low detection limit of 0.12 nmol L À1 . The association (k a ), dissociation (k d ) and equilibrium rate constants have been estimated to be 0.07 nM, 0.002 nM and 0.41 nM, respectively. This Ab-Vc/RGO-ant-TiO 2 /ITO immunoelectrode could be a suitable platform for the development of compact diagnostic devices.

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Section: Introductionmentioning

confidence: 99%

Reduced graphene oxide–titania based platform for label-free biosensor

et al. 2014

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“…In PDT, a photosensitizer (PS) is irradiated with suitable light to generate free radicals and/or ROS that irreversibly damages the cancer cells [141]. Hypocrellin-A (HA, a hydrophobic perylenequinonoid anticancer drug having photodynamic properties) was immobilized on GO with the help of π-π interaction, hydrogen bonding and hydrophobic interaction [142].…”

Section: Photothermal Therapymentioning

confidence: 99%

Graphene and graphene oxide as nanomaterials for medicine and biology application

et al. 2018

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Graphene-and graphene oxide-based nanomaterials have gained broad interests in research because of their unique physiochemical properties. The 2D allotropic structure allows it to be used in various biological fields. The biomedical applications of graphene and its composite include its use in gene and small molecular drug delivery. It is further used for biofunctionalization of protein, in anticancer therapy, as an antimicrobial agent for bone and teeth implantation. The biocompatibility of the newly synthesized nanomaterials allows its substantial use in medicine and biology. The current review summarizes the chemical structure and biological application of graphene in various fields.

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“…As compared to covalent modification, non covalent modification is less advantageous, since bonding is week and its chances of breaking is more once it comes into contact with to external environment. Different types of grapheme based materials, their properties and modification strategies are discussed by researchers [6].…”

Section: Functionalisation/modifications Of Graphene-based Materialsmentioning

confidence: 99%

“…Due to its highly reactive surface, single layer defect-free graphene is arduous to synthesize and it is also difficult to suspend in solution. Hence, compared to the single layer graphene, GO or rGO is widely used in biomedical applications [6]. Graphene has a defect-free plane and there almost exists no oxygen groups, so its electrical and optical conductivity is superb.…”

Section: Graphene Introductionmentioning

confidence: 99%

Bio- Medical Applications of Graphene, Its Modelling and Simulation

2017

IJAERD

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Keywords-Acrylonitric Butadiene Styrene (ABS), Fusion Deposition Modelling (FDM), Computer Aided Design (CAD, 3D (Three Dimensional), Carbon Nano Tubes (CNTs), GO (Graphene Oxide), Molecular Dynamics (MD)When designing a new product, engineers can best predict its end performance by prototyping with a material as similar to it as possible. A part produced has to deliver its performance in actual prevailing conditions. When designing a product, knowledge of material properties is very essential so that it can be judged whether the material can serve the intended purpose (and upto what extent) or not. Thus properties of material affect its performance and knowledge of actual performance environment helps in selection of material and its material properties. Depending on the end use, material properties are decided by the designer. Thus processing of materials is also a crucial area of study. The aim of the present work is to make a step in prediction of prototype performance of part and its material properties, thus present a road map accordingly.Processing of biomedical parts consisting of various biocompatiple properties is emerging area of study in material science. There are many processed materials which are used for biomedical applications depending on their properties. Some of the biocompatible thermoplastic materials are acrylonitric butadiene styrene (ABS), PC-ISO etc. Medical, pharmaceutical and food handling equipment have stringent regulations to protect consumers from illness and disease. Regulations include standards such as ISO 10993 and USP Class VI, which classify a material as biocompatible. ABSM30i meets these criteria so it can be used for products that come in contact with skin and food.ABS-M30i blends strength with sterilization capability. ABS-M30i can be sterilized using either gamma radiation or ethylene oxide (Eta) sterilization methods.

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Graphene based materials for biomedical applications

Cited by 582 publications

References 83 publications

Reduced graphene oxide–titania based platform for label-free biosensor

Reduced graphene oxide–titania based platform for label-free biosensor

Graphene and graphene oxide as nanomaterials for medicine and biology application

Bio- Medical Applications of Graphene, Its Modelling and Simulation

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