Graphene-based electrochemical biosensors for monitoring noncommunicable disease biomarkers

Taniselass, Steven; Arshad, M. K. Md; Gopinath, Subash C. B.

doi:10.1016/j.bios.2019.01.047

Cited by 207 publications

(82 citation statements)

References 147 publications

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“…The reduction of GO functional groups results in rGO. The structure of rGO is similar to that of GR, and it is associated with its higher electrical conductivity compared to GO [5,22,28]. Simultaneously, due to the lower content of oxygen-containing functional groups, it is more hydrophobic.…”

Section: Graphene-based Materialsmentioning

confidence: 95%

Graphenic Materials for Biomedical Applications

2019

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Graphene-based nanomaterials have been intensively studied for their properties, modifications, and application potential. Biomedical applications are one of the main directions of research in this field. This review summarizes the research results which were obtained in the last two years (2017-2019), especially those related to drug/gene/protein delivery systems and materials with antimicrobial properties. Due to the large number of studies in the area of carbon nanomaterials, attention here is focused only on 2D structures, i.e. graphene, graphene oxide, and reduced graphene oxide.

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Section: Graphene-based Materialsmentioning

confidence: 95%

Graphenic Materials for Biomedical Applications

2019

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“…This feature favors the possibility of functionalization of graphene-like materials. The chemical reduction of these functional groups results in reduced graphene oxide, which presents a similar structure than G. rGO shows higher electrical conductivity compared to GO and is more hydrophobic due to the low content of functional groups [42,43]. Other graphene-based nanostructures are carbon nanotubes (CNTs).…”

Section: Graphenic Nanofillersmentioning

confidence: 99%

Extrusion of Polymer Nanocomposites with Graphene and Graphene Derivative Nanofillers: An Overview of Recent Developments

et al. 2020

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This review is focused on the recent developments of nanocomposite materials that combine a thermoplastic matrix with different forms of graphene or graphene oxide nanofillers. In all cases, the manufacturing method of the composite materials has been melt-processing, in particular, twin-screw extrusion, which can then be followed by injection molding. The advantages of this processing route with respect to other alternative methods will be highlighted. The results point to an increasing interest in biodegradable matrices such as polylactic acid (PLA) and graphene oxide or reduced graphene oxide, rather than graphene. The reasons for this will also be discussed.

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“…Furthermore, inexpensive mass production possibilities, miniaturization, integration into fluidic systems, and with flexible circuit boards make electrochemical detection a preferred technology for sweat analysis. In fact, carbon-based electrodes dominate the electrochemical point-of-care market [15][16][17][18][19][20] and advances and better understanding of graphene suggests that it is a highly favorable transducer material.…”

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

Electrochemical multi-analyte point-of-care perspiration sensors using on-chip three-dimensional graphene electrodes

et al. 2020

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Multi-analyte sensing using exclusively laser-induced graphene (LIG)-based planar electrode systems was developed for sweat analysis. LIG provides 3D structures of graphene, can be manufactured easier than any other carbon electrode also on large scale, and in form of electrodes: hence, it is predestinated for affordable, wearable point-of-care sensors. Here, it is demonstrated that LIG facilitates all three electrochemical sensing strategies (voltammetry, potentiometry, impedance) in a multi-analyte system for sweat analysis. A potentiometric potassium-ion-selective electrode in combination with an electrodeposited Ag/AgCl reference electrode (RE) enabled the detection of potassium ions in the entire physiologically relevant range (1 to 500 mM) with a fast response time, unaffected by the presence of main interfering ions and sweat-collecting materials. A kidney-shaped interdigitated LIG electrode enabled the determination of the overall electrolyte concentration by electrochemical impedance spectroscopy at a fixed frequency. Enzyme-based strategies with amperometric detection share a common RE and were realized with Prussian blue as electron mediator and biocompatible chitosan for enzyme immobilization and protection of the electrode. Using glucose and lactate oxidases, lower limits of detection of 13.7 ± 0.5 μM for glucose and 28 ± 3 μM for lactate were obtained, respectively. The sensor showed a good performance at different pH, with sweat-collecting tissues, on a model skin system and furthermore in synthetic sweat as well as in artificial tear fluid. Response time for each analytical cycle totals 75 s, and hence allows a quasi-continuous and simultaneous monitoring of all analytes. This multi-analyte all-LIG system is therefore a practical, versatile, and most simple strategy for point-of-care applications and has the potential to outcompete standard screen-printed electrodes.

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Graphene-based electrochemical biosensors for monitoring noncommunicable disease biomarkers

Cited by 207 publications

References 147 publications

Graphenic Materials for Biomedical Applications

Graphenic Materials for Biomedical Applications

Extrusion of Polymer Nanocomposites with Graphene and Graphene Derivative Nanofillers: An Overview of Recent Developments

Electrochemical multi-analyte point-of-care perspiration sensors using on-chip three-dimensional graphene electrodes

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