Grape seed proanthocyanidin extract ameliorates hepatic lipid accumulation and inflammation in grass carp (Ctenopharyngodon idella)

Lu, Rongzhu; Qin, Chaobin; Yang, Feng; Zhang, Wenya; Zhang, Yuru; Yang, Guokun; Yang, Liping; Meng, Xiaolin; Yan, Xiao; Nie, Guoxing

doi:10.1007/s10695-020-00819-3

Cited by 26 publications

(18 citation statements)

References 44 publications

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“…Furthermore, GSPE treatment of the NAFLD rats showed significant down regulation of IL-1β, PPARα, TGF-β1 and TIMP1expression levels in the hepatic tissues when compared with the NAFLD rats. Similarly, Lu et al (2020) declared that GSPE significantly attenuated the expression of IL-1β. Moreover, Nie et al (2017) found that, trimer gallate of oligomeric proanthocyanidins down-regulated the nuclear hormone receptor-49 (an ortholog of the human PPARα), a key regulator of fat metabolism.…”

Section: Discussionmentioning

confidence: 98%

Grape Seed Proanthocyanidin Extract And Antiplatelet drug (Clopidogrel) Alleviates Nonalcoholic Fatty Liver Disease Via Inhibition Of Hepatic Inflammation In Rats

Hussein

zaid

Azab

et al. 2021

Benha Veterinary Medical Journal

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Non-alcoholic fatty liver disease (NAFLD) is a complex disease caused by a number of different pathogenic processes as a result of the systemic interaction between the liver and several other organs. Grape seeds proanthocyanidins extract (GSPE) potency in the liver is associated with improvement of the hepatic enzyme activities as their powerful antioxidant property results from its ability to directly scavenge free radicals and/or chelate metals. Thirty-two male albino rats were assigned into 4 equal groups of 8 rats as: Normal control group (G1): Rats fed ordinary normal diet for 12 weeks. NAFLD group (G2): Rats provided with HFD-diet for 6 weeks for NAFLD induction, followed by ordinary normal diet for another 6 weeks. NAFLD + GSPE treated group (G3): Rats fed HFD for 6 weeks (NAFLD) followed by administration of GSPE for another 6 weeks. NAFLD + GSPE + clopidogrel treated group (G4): Rats fed HFD for 6 weeks, followed by administration of GSPE and clopidogrel for additional 6 weeks. The results revealed that treatment with GSPE or in combination with clopidogrel (G3, G4) significantly decreased the higher activities of serum AST, ALT and γ GT in NAFLD induced rats (G2). Interestingly, the gene expressions ofIL-1β, PPARα, TGF-β1 and TIMP1 inliver tissue significantly down regulated in GSPE (G3) and GSPE + clopidogrel (G4) treated groups as compared with NAFLD group (G2). In conclusion, treatment with GSPE and in combination with clopidogrel is alternative therapiesand powerful anti-inflammatory, protect liver cells against fatty liver disease via restoring the hepatocytes function and inflammatory mediators.

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Section: Discussionmentioning

confidence: 98%

Grape Seed Proanthocyanidin Extract And Antiplatelet drug (Clopidogrel) Alleviates Nonalcoholic Fatty Liver Disease Via Inhibition Of Hepatic Inflammation In Rats

Hussein

zaid

Azab

et al. 2021

Benha Veterinary Medical Journal

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“…The reason is that, once administered in vivo, some of them can fail, leading to the loss of their cargo prior to target immunocompetent fish cells [30,31]. Among antioxidant agents, the whole GSE mixture has been studied for its beneficial effects on fish cells [3,4], Moreover, even the isolated polyphenols arising from GSE; namely, resveratrol was found to inhibit both lipopolysaccharide-induced and endogenous eicosanoid production [32], and polyphenol-enriched extract was seen to decrease the oxidative stress and extend the life span of medaka fish [33].…”

Section: Discussionmentioning

confidence: 99%

“…In this context, we previously studied a mixture based on Apulian grape seed extract (GSE) for its favorable antioxidant and anti-inflammatory effects in human cells due to the relevant pro-anthocyanidin and polyphenol content (Figure 1; in [1,2]). With regard to pro-anthocyanidins contained in GSE, previous studies in the area of fish immunology Molecules 2022, 27, 344 2 of 21 elucidated that, once excessive fat accumulation takes place in fish, with consequent hepatic lipid metabolism disorder, then GSE allows hypolipidemic and potential anti-inflammatory effects in the liver, as occurred, for instance, in grass carp [3]. Moreover, the antioxidant effects of GSE were recently evaluated in a zebrafish embryo model [4].…”

Section: Introductionmentioning

confidence: 99%

“…Molecules 2022, 27, x FOR PEER REVIEW 2 of 21 anthocyanidins contained in GSE, previous studies in the area of fish immunology elucidated that, once excessive fat accumulation takes place in fish, with consequent hepatic lipid metabolism disorder, then GSE allows hypolipidemic and potential anti-inflammatory effects in the liver, as occurred, for instance, in grass carp [3]. Moreover, the antioxidant effects of GSE were recently evaluated in a zebrafish embryo model [4].…”

Section: Introductionmentioning

confidence: 99%

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Solid Lipid Nanoparticles Administering Antioxidant Grape Seed-Derived Polyphenol Compounds: A Potential Application in Aquaculture

et al. 2022

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The supply of nutrients, such as antioxidant agents, to fish cells still represents a challenge in aquaculture. In this context, we investigated solid lipid nanoparticles (SLN) composed of a combination of Gelucire® 50/13 and Precirol® ATO5 to administer a grape seed extract (GSE) mixture containing several antioxidant compounds. The combination of the two lipids for the SLN formation resulted in colloids exhibiting mean particle sizes in the range 139–283 nm and zeta potential values in the range +25.6–43.4 mV. Raman spectra and X-ray diffraction evidenced structural differences between the free GSE and GSE-loaded SLN, leading to the conclusion that GSE alters the structure of the lipid nanocarriers. From a biological viewpoint, cell lines from gilthead seabream and European sea bass were exposed to different concentrations of GSE-SLN for 24 h. In general, at appropriate concentrations, GSE-SLN increased the viability of the fish cells. Furthermore, regarding the gene expression in those cells, the expression of antioxidant genes was upregulated, whereas the expression of hsp70 and other genes related to the cytoskeleton was downregulated. Hence, an SLN formulation containing Gelucire® 50/13/Precirol® ATO5 and GSE may represent a compelling platform for improving the viability and antioxidant properties of fish cells.

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“…With growing interest in the utilization of phytogenic feed additives as an eco-friendly measure to ensure the sustainability of aquaculture, proanthocyanidins have been widely reported as a functional feed additive to exert growth promotion effects and improve the health status of some fish species, including the American eel ( Anguilla rostrata ), common carp ( Cyprinus carpio ), hybrid sturgeon ( Acipenser baeri Brandt ♀ × A. schrenckii Brandt ♂), rainbow trout ( Oncorhynchus mykiss ), and tilapia ( Oreochromis niloticus ) [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. The hypolipidemic effect of proanthocyanidins has attracted much attention for its potential to improve the health of humans [ 1 ] and some fish species, including the American eel, grass carp ( Ctenopharyngodon idella ), and tilapia [ 3 , 4 , 10 , 11 ]. At present, the proanthocyanidins reported in aquatic animals are mainly from grape seed proanthocyanidins (GSP).…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Supplementation of Peanut Skin Proanthocyanidins on Growth Performance and Lipid Metabolism of the Juvenile American Eel (Anguilla rostrata)

Wang

Chen

et al. 2022

Animals

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As a functional feed additive, grape seed proanthocyanidin extract has received a lot of attention due to its biological activity in the health of aquatic animals, but its high cost limits the application of this feed additive in the diet of many fish species. It is thus urgent to develop a new resource of proanthocyanidin extract. We aimed to investigate the effects of dietary supplementation with peanut skin proanthocyanidins (PSPc) on growth parameters and lipid metabolism of juvenile American eel (Anguilla rostrata). Four hundred and fifty juvenile eels were randomly divided into five groups fed diets with five PSPc supplementation levels. The trial lasted for 8 weeks. Dietary PSPc supplementation significantly improved weight gain and feed utilization, and the best growth performance was found in the group fed with 900 mg/kg PSPc. PSPc supplementation significantly affected the crude protein level of whole fish and serum lipid parameters, and the best lipid-lowering effect was found in the fish fed with 900 mg/kg PSPc. Dietary PSPc supplementation increased lipolytic enzyme activities and decrease lipid synthase levels in the liver. The lipid metabolites affected by 900 mg/kg PSPc in the liver were mainly upregulated phosphatidylethanolamine in autophagy, downregulated ceramides in sphingolipid metabolism, upregulated phosphatidylcholine and phosphatidylethanolamine, downregulated 2-lysophosphatidylcholine in glycerophospholipid metabolism, and upregulated phosphatidylcholine in linoleic acid metabolism. In conclusion, an appropriate level of PSPc might effectively improve growth performance and regulate the lipid metabolism of the juvenile American eel, and 900 mg/kg PSPc is recommended in the diet of this fish species.

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Grape seed proanthocyanidin extract ameliorates hepatic lipid accumulation and inflammation in grass carp (Ctenopharyngodon idella)

Cited by 26 publications

References 44 publications

Grape Seed Proanthocyanidin Extract And Antiplatelet drug (Clopidogrel) Alleviates Nonalcoholic Fatty Liver Disease Via Inhibition Of Hepatic Inflammation In Rats

Grape Seed Proanthocyanidin Extract And Antiplatelet drug (Clopidogrel) Alleviates Nonalcoholic Fatty Liver Disease Via Inhibition Of Hepatic Inflammation In Rats

Solid Lipid Nanoparticles Administering Antioxidant Grape Seed-Derived Polyphenol Compounds: A Potential Application in Aquaculture

Effects of Dietary Supplementation of Peanut Skin Proanthocyanidins on Growth Performance and Lipid Metabolism of the Juvenile American Eel (Anguilla rostrata)

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