Grape seed extract reduces oxidative stress and fibrosis in experimental biliary obstruction

Abstract

These results suggest that GSE protects the liver from oxidative damage following bile duct ligation in rats. This effect possibly involves the inhibition of neutrophil infiltration and lipid peroxidation; thus, restoration of oxidant and antioxidant status in the tissue.

Proanthocyanidin as a cytogenetic protective agent against adverse effects of plant growth regulators supplementation in rats

“…The administration of proanthocyanidin (PAC) caused significant histopathological improvement in hepatic and testicular tissues. This is in agreement with Hassan (2005), Juan et al (2005), Dulundu et al (2007), Sehirli et al (2008) and Shin et al (2010). The last authors found that PAC remarkably reduced extensive hemorrhagic, necrosis and disruption of tissue architecture of hepatocytes due to dimethylnitrosamine administration and may be useful in preventing the development of hepatic fibrosis of rats.…”

Effects of beta-glucan on hepatic damage caused by obstructive jaundice

“…[21] TS'de MDA düzeyinin arttığı çeşitli çalışmalarla ortaya konulmuştur. [18,[22][23][24][25][26] LPO'da benzer şekilde hücre-sel hasara işaret eder. Beta glukanın sepsis, yanık gibi durumlarda ortaya çıkan karaciğer hasarını ve MDA seviyesini azalttığını bildiren yayınlar vardır.…”

Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat red blood cells and plasma

“…GSSE has wide-ranging benefits including cardioprotective (Decordé et al, 2009), renoprotective (Safa et al, 2010), and neuroprotective (Wang et al, 2009) effects. GSSE also protects against hepatic ischemia-reperfusion injury (Sehirli et al, 2008), biliary obstruction (Dulundu et al, 2007), and azathioprineinduced hepatotoxicity in rats (El-Ashmawy et al, 2010). More specifically, resveratrol is multi-organ protective owing to its anti-oxidant (Kelen and Tepe, 2007) and anti-inflammatory properties (Kowalczyk et al, 2010).…”