Grape Seed Extract and Dentin Remineralization

Yassen, Asmaa A.; Safy, Rehab Khalil

doi:10.21608/edj.2018.78418

Cited by 8 publications

(24 citation statements)

References 33 publications

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“…In a study comparing GSE or NaF treatments with either NaF þ GSE, or no treatment, there were no significant differences between GSE, NaF, or NaF þ GSE treatment groups, and all treatments resulted in significant improvements in microhardness during the study duration compared with no treatment (10% GSE, 1 mg/L NaF, 10% GSE þ 1 mg/L NaF and deuterium-depleted water, DDW, group; 40.87 + 9.92, 44.60 + 12.48, 48.54 + 9.27 and 15.98 + 8.33 gigapascal, GPa, respectively) (Shi et al, 2015). Similarly, dental fragments subjected to 15% GSE treatment resulted in non-inferior remineralization compared with 1000 ppm NaF, and resulted in significant improvements in microhardness compared with no-treatment control (49.3 + 3.8, 49.2 + 5, 20.2 + 2.7 VHN in GSE, NaF, and control, respectively, p < 0.005) (Yassen and Safy, 2018). Another research report noted remineralization in the lowest range reviewed when 6.5% GSE-treated teeth resulted in significantly improved microhardness scores compared with NaF (78.4 + 12.4 and 45.3 + 22.4 VHN, GSE, and NaF, respectively) (Benjamin et al, 2012).…”

Section: Remineralizationmentioning

confidence: 92%

“…The most common method employed to explore GSE's impact on dental restoration after acid treatment used 10 min treatment following pH cycling six times daily for eight days, designed to mimic repeated assaults to enamel and dentin tissues by food consumption and bacteria-mediated acid production (Bedran-Russo et al, 2013;Benjamin et al, 2012;Jawale et al, 2017;Mirkarimi et al, 2013;Rubel et al, 2016;Shi et al, 2015;Silva et al, 2015;Xie et al, 2008;Yassen and Safy, 2018). In all studies, dental fragments, either 1) bovine (Silva et al, 2015) or 2) human (Bedran-Russo et al, 2013;Benjamin et al, 2012;Jawale et al, 2017;Mirkarimi et al, 2013;Rubel et al, 2016;Shi et al, 2015;Xie et al, 2008;Yassen and Safy, 2018), were subjected to treatments. Other treatment conditions included 2 min acid degradation of human molars, followed by 14 days of pH cycling (Tang et al, 2013), or using bovine molars to assess changes after 5 min exposure to an Indian energy drink followed by 16 or 32 min GSE gel application (Saragih et al, 2017).…”

Section: Remineralizationmentioning

confidence: 99%

“…Other treatment conditions included 2 min acid degradation of human molars, followed by 14 days of pH cycling (Tang et al, 2013), or using bovine molars to assess changes after 5 min exposure to an Indian energy drink followed by 16 or 32 min GSE gel application (Saragih et al, 2017). GSE treatment concentrations varied between studies, which most often analyzed the impact of 6.5% (Benjamin et al, 2012; Rubel et al, 2016; Saragih et al, 2017) or 12.5% (Mirkarimi et al, 2013;Saragih et al, 2017) GSE solution or gel, but also employed comparison of 5% (Tang et al, 2013), 10% (Shi et al, 2015, Tang et al, 2013 or 15% (Tang et al, 2013;Yassen and Safy, 2018) GSE solutions with no treatment. Studies used changes in dental microhardness measurements as a surrogate for remineralization; teeth with greater remineralization had greater improvement in microhardness measurements from baseline to study end.…”

Section: Remineralizationmentioning

confidence: 99%

“…In studies comparing remineralization outcomes in GSE-treated compared to fluoride-treated groups or no treatment, GSE treatment was consistently non-inferior to fluoride dentin remineralization (Shi et al, 2015;Yassen and Safy, 2018). In a study comparing GSE or NaF treatments with either NaF þ GSE, or no treatment, there were no significant differences between GSE, NaF, or NaF þ GSE treatment groups, and all treatments resulted in significant improvements in microhardness during the study duration compared with no treatment (10% GSE, 1 mg/L NaF, 10% GSE þ 1 mg/L NaF and deuterium-depleted water, DDW, group; 40.87 + 9.92, 44.60 + 12.48, 48.54 + 9.27 and 15.98 + 8.33 gigapascal, GPa, respectively) (Shi et al, 2015).…”

Section: Remineralizationmentioning

confidence: 99%

“…Tannins' role in collagen crosslinking and propensity to strong (Santos-buelga and Scalbert, 2000; Shimada, 2006), difficult to hydrolyze bonds (Shimada, 2006) make it an interesting theoretical agent for dentin remineralization and for preventing degradation of enamel and dentin surfaces via both inhibition of collagenolytic enzymes and strengthening existing dentin matrices. Of the 14 studies appraised exploring GSE's role in dental remineralization, tensile strength, and preventing degradation, 11 found significant benefits to dentin microhardness with GSE treatment conditions compared with control (Bedran-Russo et al, 2013;Benjamin et al, 2012;Boteon et al, 2017;Epasinghe et al, 2014;Jawale et al, 2017;Macedo et al, 2009;Mirkarimi et al, 2013;Rubel et al, 2016;Saragih et al, 2017;Shi et al, 2015;Silva et al, 2015;Tang et al, 2013;Xie et al, 2008;Yassen and Safy, 2018). Compared with no treatment, GSE showed consistent and significant improvement in both remineralization from acid etched surfaces and degradation of dentin by acid rich environments (Benjamin et al, 2012;Boteon et al, 2017;Epasinghe et al, 2014;Jawale et al, 2017;Mirkarimi et al, 2013;Rubel et al, 2016;Saragih et al, 2017;Shi et al, 2015;Xie et al 2008;Yassen and Safy, 2018).…”

Section: Gse and Dentin Restorationmentioning

confidence: 99%

See 4 more Smart Citations

Prevention of dental caries by grape seed extract supplementation: A systematic review

Delimont

Carlson

2019

Nutr Health

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Background: Dental caries are the most prominent chronic disease of children and adults worldwide, and facilitating evidence-based, preventative care for their prevention is critical. Caries are traditionally and successfully prevented by regular fluoride use, but there are opportunities to halt and restore caries with alternative agents in addition to fluoride use. Grape seed extract (GSE) is a readily available plant-based supplement that, due to its concentrated levels of proanthocyanidins, has promising characteristics that may assist in dental caries prevention. Aim: The goal of this review was to investigate whether current research supports use of grape seed extract to prevent dental caries formation. Methods: A systematic review of articles related to grape seed extract, prevention of dental caries, inhibition of Streptococcus mutans, and remineralization was conducted. Articles were first chosen by inclusion of dental models that used grape seed extract as an intervention, and then by strength of study design. Results: Twenty articles were reviewed. Studies overall supported three unique grape seed extract properties facilitating dental caries prevention. In the first articles reviewed, grape seed extract inhibited proliferation of bacterial biofilms on tooth surfaces. In addition, studies reviewed indicated that grape seed extract promoted dental remineralization. Conclusions: Caries prevention by grape seed extract may be unique compared with fluoride, and is linked to grape seed extract’s bacteriostatic and collagen crosslinking properties. Future research should investigate potential delivery methods, and benefits of combined grape seed extract use with known caries preventative agents, in human participants.

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Section: Remineralizationmentioning

confidence: 92%

Section: Remineralizationmentioning

confidence: 99%

Section: Remineralizationmentioning

confidence: 99%

Section: Remineralizationmentioning

confidence: 99%

Section: Gse and Dentin Restorationmentioning

confidence: 99%

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Prevention of dental caries by grape seed extract supplementation: A systematic review

Delimont

Carlson

2019

Nutr Health

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Evaluation of Remineralizing Potential of White Tea and Green Tea on Artificially Demineralized Dentin (In-Vitro Study)

Sayed

Roushdy

2023

Ahram Canadian Dental Journal

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Purpose:The aim of this study was to evaluate the remineralizing potential of white tea and green tea pretreatment on microhardness of demineralized dentin. Materials and Methods: A total number of 21 dentin samples were divided into three main groups of 7samples each according to the utilized treatment after demineralization. In the first group, dentin samples were immersed in 10% white tea extract solution followed by casein phosphopeptide amorphous calcium phosphate application. In the second group, samples were immersed in 10% green tea extract solution followed by casein phosphopeptide amorphous calcium phosphate application, while in the third group ,casein phosphopeptide amorphous calcium phosphate(CPP-ACP) only was applied on dentin surface. Microhardness was evaluated at baseline, after demineralization and after treatment for all dentin samples. Results: Microhardness mean values results revealed statistically significant increase in all groups after treatment .The highest percent of change of microhardness was found in white tea group, followed by green tea, while the control group revealed the lowest percent of change. Conclusions: Tea extracts increased dentin microharness when used before application of remineralizing agent. However, white tea extract showed better microhardness values indicating stabilization of dentin collagen network resulting in functional remineralization.

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Surface Microhardness of Bleached Teeth Enamel Following Different Remineralizing Approaches (In-Vitro Study)

Mousa,

Abdel-Fattah,

Afifi

2023

Alexandria Dental Journal

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INTRODUCTION:In-office bleaching is a conservative and effective esthetic dental procedure, but it has a serious effect on the enamel matrix structure's integrity, altering its surface microhardness (SMH). Therefore, the use of different remineralizing approaches (reparative or regenerative) after vital bleaching procedures is recommended to improve the SMH of the bleached enamel. AIM OF THE STUDY:The purpose of this study was to see how different remineralization approaches influenced the SMH of the bleached enamel. MATERIALS AND METHODS: Crowns of 57 extracted human maxillary central incisors were bleached with a chemically activated bleaching gel containing 40% hydrogen peroxide. Then, based on the remineralizing agent that would be used after bleaching, they were randomly categorized into 3 groups (n=19). Group, I was self-assembling peptide (CURODONT™ REPAIR, Credentis AG, Switzerland), Group II was casein phosphopeptide stabilized amorphous calcium phosphate 'CAP-ACP' ACP' (GC Tooth Mousse, GC Corporation, Tokyo, Japan) and Group III was sodium fluoride (Whitesmile mousse, Whitesmile GmbH; Germany). The specimen's SMH was measured before bleaching, after bleaching, 24 hours, and 1 week after remineralization using a Vickers microhardness tester. RESULTS: There was a statistically significant increase in Vickers Hardness Number (VHN) across the three study groups only 24 hours following remineralization. The highest VHN was recorded for Gp I (317.30), followed by Gp II (304.63), followed by Gp III (284.02), with the statistical significance only between group I and group III (0.005*). Group III presented the highest VHN 1week after remineralization (312.33) in relation to baseline VHN (287.06). CONCLUSIONS:The best results were obtained with the self-assembling peptide over both CCP-ACP and sodium fluoride 24 hrs. from its application in SMH recovery.

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Grape Seed Extract and Dentin Remineralization

Cited by 8 publications

References 33 publications

Prevention of dental caries by grape seed extract supplementation: A systematic review

Prevention of dental caries by grape seed extract supplementation: A systematic review

Evaluation of Remineralizing Potential of White Tea and Green Tea on Artificially Demineralized Dentin (In-Vitro Study)

Surface Microhardness of Bleached Teeth Enamel Following Different Remineralizing Approaches (In-Vitro Study)

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