Grape Consumption Increases Anti-Inflammatory Markers and Upregulates Peripheral Nitric Oxide Synthase in the Absence of Dyslipidemias in Men with Metabolic Syndrome

Barona, Jacqueline; Blesso, Christopher N.; Andersen, Catherine J.; Park, Youngki; Lee, Ji-Young; Fernández, María Luz

doi:10.3390/nu4121945

Cited by 46 publications

(35 citation statements)

References 32 publications

(61 reference statements)

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“…48 Grape consumption showed favorable responses by increasing IL-10 and adiponectin, two anti-inflammatory cytokines, in non-dyslipidemic subjects. In addition, iNOS expression was higher in PBMCs from non-dyslipidemic individuals.…”

Section: Grape and Whole-grape Products For Better Healthmentioning

confidence: 96%

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Resveratrol, in its natural combination in whole grape, for health promotion and disease management

Singh

Liu

Ahmad

2015

Annals of the New York Academy of Sciences

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The grape antioxidant resveratrol has been a topic of intense research for the past three decades. Resveratrol and other grape ingredients, as well as whole-grape products, have shown considerable promise in health promotion and disease management. Phytochemically, whole grape represents a natural combination of resveratrol and other phytonutrients, as it contains several catechins, anthocyanins, polyphenols, and flavonols. Thus, the whole grape products or specific combinations of grape constituents provide us with the possibility of synergistic interactions leading to improved efficacy. Recent research has suggested that whole-grape products may help in maintaining heart health and protect against aging, aging-associated diseases, neurodegeneration, and some cancers. Based on the available recent literature, the grape or whole-grape products seem to be safer choices for better health and disease prevention. However, for advanced disease conditions, individual grape ingredients (such as resveratrol) or combinations of multiple ingredients together with existing therapies appear to be better approaches. Further clinical studies are needed to understand the benefits of grapes and their products in the prevention and management of specific diseases.

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Section: Grape and Whole-grape Products For Better Healthmentioning

confidence: 96%

“…In addition, iNOS expression was higher in PBMCs from non-dyslipidemic individuals. 48 Why grape consumption did not provide benefits to men with dyslipidemia may be the subject of future research. In a separate study, Barona et al .…”

Section: Grape and Whole-grape Products For Better Healthmentioning

confidence: 99%

Resveratrol, in its natural combination in whole grape, for health promotion and disease management

Singh

Liu

Ahmad

2015

Annals of the New York Academy of Sciences

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“…Following citrus‐based juice and hesperidin supplementation, CRP was significantly decreased and was associated to improved endothelial function in MetS individuals . Concerning the circulatory tumour ‐necrosis factor (TNF‐α) associated inflammation, while blueberries and grapes did not produce any change in TNF‐α, bilberries and sea buckthorn or quercetin significantly reduced its level. Furthermore, no study in MetS subjects reported changes in interleukin‐6 (IL‐6) following green tea, cranberry or grape supplementation .…”

Section: Effects Of Polyphenols and Associated Mechanisms On The Mainmentioning

confidence: 99%

“…Concerning the circulatory tumour ‐necrosis factor (TNF‐α) associated inflammation, while blueberries and grapes did not produce any change in TNF‐α, bilberries and sea buckthorn or quercetin significantly reduced its level. Furthermore, no study in MetS subjects reported changes in interleukin‐6 (IL‐6) following green tea, cranberry or grape supplementation . It has been suggested that the lack of changes may be because of the baseline inflammatory value and/or that the anti‐hypertensive treatment usually received by the patients may explain the absence of additional effects due its anti‐inflammatory effects .…”

Section: Effects Of Polyphenols and Associated Mechanisms On The Mainmentioning

confidence: 99%

Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review

2016

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SummaryDietary polyphenols constitute a large family of bioactive substances potential beneficial effect on metabolic syndrome (MetS). This review summarizes the results of clinical studies on patients with MetS involving the chronic supplementation of a polyphenol-rich diet, foods, extracts or with single phenolics on the features of MetS (obesity, dyslipidemia, blood pressure and glycaemia) and associated complications (oxidative stress and inflammation). Polyphenols were shown to be efficient, especially at higher doses, and there were no specific foods or extracts able to alleviate all the features of MetS. Green tea, however, significantly reduced body mass index and waist circumference and improved lipid metabolism. Cocoa supplementation reduced blood pressure and blood glucose. Soy isoflavones, citrus products, hesperidin and quercetin improved lipid metabolism, whereas cinnamon reduced blood glucose. In numerous clinical studies, antioxidative and anti-inflammatory effects were not significant after polyphenol supplementation in patients with MetS. However, some trials pointed towards an improvement of endothelial function in patients supplemented with cocoa, anthocyanin-rich berries, hesperidin or resveratrol. Therefore, diets rich in polyphenols, such as the Mediterranean diet, which promote the consumption of diverse polyphenol-rich products could be an effective nutritional strategy to improve the health of patients with MetS.

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“…Endothelial and nitric oxide pathways are implicated in the beneficial effects on cardiovascular outcomes induced by CGJ and other polyphenol-rich foods and drinks (11,12). The allostatic load model describes how chronic stress, cardiovascular disease, and associated risk factors can lead to a cascade of physiological and psychological consequences, such as cognitive impairment (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Concord grape juice, cognitive function, and driving performance: a 12-wk, placebo-controlled, randomized crossover trial in mothers of preteen children

Lamport¹,

Lawton²,

Merat

et al. 2016

The American Journal of Clinical Nutrition

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Background: Daily consumption of Concord grape juice (CGJ) over 3-4 mo has been shown to improve memory function in adults with mild cognitive impairment and reduce blood pressure in hypertensive adults. These benefits likely result from the high concentration of polyphenols in CGJ. Increased stress can impair cognitive function and elevate blood pressure. Thus, we examined the potential beneficial effect of CGJ in individuals with somewhat stressful and demanding lifestyles. Objective: We sought to examine the effects of the daily consumption of CGJ for 12 wk on cognitive function, driving performance, and blood pressure in healthy, middle-aged working mothers. Design: Twenty-five healthy mothers (aged 40-50 y) of preteen children who were employed for $30 h/wk consumed 12 ounces (355 mL) of either CGJ (containing 777 mg total polyphenols) or an energy-, taste-, and appearance-matched placebo daily for 12 wk according to a randomized crossover design with a 4-wk washout. Verbal and spatial memory, executive function, attention, blood pressure, and mood were assessed at baseline and at 6 and 12 wk. Immediately after the cognitive battery, a subsample of 17 women completed a driving performance assessment at the University of Leeds Driving Simulator. The 25-min driving task required participants to match the speed and direction of a lead vehicle. Results: Significant improvements in immediate spatial memory and driving performance were observed after CGJ relative to placebo. There was evidence of an enduring effect of CGJ such that participants who received CGJ in arm 1 maintained better performance in the placebo arm. Conclusions: Cognitive benefits associated with the long-term consumption of flavonoid-rich grape juice are not exclusive to adults with mild cognitive impairment. Moreover, these cognitive benefits are apparent in complex everyday tasks such as driving. Effects may persist beyond the cessation of flavonoid consumption, and future studies should carefully consider the length of washout within crossover designs. This trial was registered at clinicaltrials.gov as NCT01411631.Am J Clin Nutr 2016;103:775-83.

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Grape Consumption Increases Anti-Inflammatory Markers and Upregulates Peripheral Nitric Oxide Synthase in the Absence of Dyslipidemias in Men with Metabolic Syndrome

Cited by 46 publications

References 32 publications

Resveratrol, in its natural combination in whole grape, for health promotion and disease management

Resveratrol, in its natural combination in whole grape, for health promotion and disease management

Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review

Concord grape juice, cognitive function, and driving performance: a 12-wk, placebo-controlled, randomized crossover trial in mothers of preteen children

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