Concord grape juice, cognitive function, and driving performance: a 12-wk, placebo-controlled, randomized crossover trial in mothers of preteen children

Lamport, Daniel J.; Lawton, Clare; Merat, Natasha; Jamson, Hamish; Myrissa, Kyriaki; Hofman, Denise; Chadwick, H.K.; Quadt, Frits; Wightman, JoLynne D.; Dye, Louise

doi:10.3945/ajcn.115.114553

Cited by 74 publications

(82 citation statements)

References 37 publications

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“…For instance, after 12 weeks of grape juice supplementation [21], a significant improvement on cognitive performance in healthy middle-aged individuals without effect on depressive symptoms was found. In accordance, healthy adult women also showed important improvements in immediate spatial memory following 12 weeks of daily grape juice consumption [42]. Contrarily to these findings, in our study, the memory performance was not improved in the GJG.…”

Section: Sift Desksupporting

confidence: 86%

Grape juice consumption and/or exercise training-induced neuroplasticity and memory improvement in healthy elderly women

Elsner¹,

Trevizol²,

Bassôa³

et al. 2018

SDRP-JCMP

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Background: Emerging evidences have been pointed out that exercise in combination with dietary factors is able to affect molecular events related to synaptic plasticity and cognitive improvement. Therefore, this study sought to verify the impact of grape juice consumption and/or exercise in plasma neurotrophic factor (BDNF) levels and memory performance in elderly women. Methods: Nineteen healthy elderly women were randomly distributed in two groups: Grape Juice Group (GJG, n=9) and Grape Juice + Exercise Group (GJEG, n=10). The GJG was instructed to drunk daily the grape juice (400 ml) for 30 days, while the GJEG was also submitted to a physical exercise intervention (twice a week, 60 min/session). Memory function was assessed via the MoCA (Montreal Cognitive Assessment) and blood sampling was taken for BDNF analysis pre/post intervention in both groups. Results: It was observed a significant increase on BDNF levels in GJG (p=0.000) and GJEG (p=0.041) after intervention, while the memory improvement was verified only in GJEG (p=0.024). No differences between groups were found in the variables. Conclusion: In conclusion, the grape juice consumption per se is capable to modulates/increases BDNF levels, response that was not potentiated by exercise practice. On the other hand, the memory performance was improved only when grape juice consumption is combined to exercise intervention in healthy elderly women.

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Section: Sift Desksupporting

confidence: 86%

Grape juice consumption and/or exercise training-induced neuroplasticity and memory improvement in healthy elderly women

Elsner¹,

Trevizol²,

Bassôa³

et al. 2018

SDRP-JCMP

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“…After detailed analysis of the full text, 113 articles were rejected, due to lack of relevant outcomes, aspects of the study design, etc. Finally, 128 human RCTs published between March 1995 and March 2016 (included) [34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,…”

Section: Resultsmentioning

confidence: 99%

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

Garcı́a-Conesa

Chambers

Combet

et al. 2018

IJMS

111

107

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Understanding interindividual variability in response to dietary polyphenols remains essential to elucidate their effects on cardiometabolic disease development. A meta-analysis of 128 randomized clinical trials was conducted to investigate the effects of berries and red grapes/wine as sources of anthocyanins and of nuts and pomegranate as sources of ellagitannins on a range of cardiometabolic risk biomarkers. The potential influence of various demographic and lifestyle factors on the variability in the response to these products were explored. Both anthocyanin- and ellagitannin-containing products reduced total-cholesterol with nuts and berries yielding more significant effects than pomegranate and grapes. Blood pressure was significantly reduced by the two main sources of anthocyanins, berries and red grapes/wine, whereas waist circumference, LDL-cholesterol, triglycerides, and glucose were most significantly lowered by the ellagitannin-products, particularly nuts. Additionally, we found an indication of a small increase in HDL-cholesterol most significant with nuts and, in flow-mediated dilation by nuts and berries. Most of these effects were detected in obese/overweight people but we found limited or non-evidence in normoweight individuals or of the influence of sex or smoking status. The effects of other factors, i.e., habitual diet, health status or country where the study was conducted, were inconsistent and require further investigation.

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“…Daily intake of Concord grape juice over three to four months has been shown to improve memory function in adults with mild cognitive impairment [168]. Healthy mothers who consumed twelve ounces of either Concord grape juice or an energy-matched placebo daily for twelve weeks showed significant improvements in immediate spatial memory and driving performance with the grape juice compared with placebo [168]. ese effects are not limited to those who are older in age or after chronic consumption.…”

Section: Blue-purple Foods and Cognitionmentioning

confidence: 99%

A Review of the Science of Colorful, Plant-Based Food and Practical Strategies for “Eating the Rainbow”

Minich

2019

Journal of Nutrition and Metabolism

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Over the past decades, thousands of published studies have amassed supporting recommendations to consume fruits and vegetables for physiological and psychological health. Newer research has emerged to suggest that these plant-based foods contain a plethora of not only vitamins and minerals, but perhaps, most importantly, phytonutrients. These phytonutrients have known pleiotropic effects on cellular structure and function, ultimately resulting in the modulation of protein kinases and subsequent epigenetic modification in a manner that leads to improved outcomes. Even though eating fruits and vegetables is a well-known feature of a healthy dietary pattern, population intakes continue to be below federal recommendations. To encourage consumers to include fruits and vegetables into their diet, an “eat by color” approach is proposed in this review. Although each individual food may have numerous effects based on its constituents, the goal of this simplified approach was to identify general patterns of benefits based on the preponderance of scientific data and known mechanisms of food-based constituents. It is suggested that such a consumer-oriented categorization of these plant-based foods may lead to greater recognition of their importance in the daily diet throughout the lifespan. Other adjunctive strategies to heighten awareness of fruits and vegetables are discussed.

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Concord grape juice, cognitive function, and driving performance: a 12-wk, placebo-controlled, randomized crossover trial in mothers of preteen children

Cited by 74 publications

References 37 publications

Grape juice consumption and/or exercise training-induced neuroplasticity and memory improvement in healthy elderly women

Grape juice consumption and/or exercise training-induced neuroplasticity and memory improvement in healthy elderly women

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

A Review of the Science of Colorful, Plant-Based Food and Practical Strategies for “Eating the Rainbow”

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