Granulosa-cell Tumours Causing Precocious Puberty

Bruk, I.; Dancaster, C. P.; Jackson, W. P. U.

doi:10.1136/bmj.2.5191.26

Cited by 12 publications

(2 citation statements)

References 4 publications

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“…Few of these tumours are without demonstrable endocrine function (Morris & Scully, 1958). Increased urinary excretion of oestrogens has been reported in patients with granulosa cell tumours (Bruk et al 1960;Dorfman, 1960;Marsh et al 1962). The clinical features and cystic hyperplasia of the endometrium provide evidence for the oestrogen secretion by the tumour described in this report.…”

Section: Discussionmentioning

confidence: 97%

“…1958;Lyon, Sinykin & McKelvey, 1963) and may occur from childhood to old age. The clinical symptoms associated with these tumours, namely precocious puberty, menstrual disturbances, or post-menopausal bleeding, are attributed to oestrogen secretion by the tumour, and high oestrogen concentrations have been reported in urine from patients with such tumours (Bruk, Dancaster & Jackson, 1960;Dorfman, 1960;Marsh, Savard, Baggett, Van Wyk & Talbert, 1962). Thecal cells are often present in the tumour and are sometimes prominent enough to justify the term 'granulosa-theca cell tumour'.…”

Section: Introductionmentioning

confidence: 95%

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Steroid Biosynthesis 'In Vitro' by Granulosa-Theca Cell Tumour Tissue

Griffiths¹,

Grant²,

Symington³

1964

Journal of Endocrinology

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The metabolism of [4-14C]progesterone and [4-14C]androst-4-ene-3,17-dione (androstenedione) by a granulosa-theca cell tumour of the ovary, 310 g. in weight, removed from a 43-year-old post-menopausal woman has been studied in vitro.The experiments provided no evidence that the tumour could utilize progesterone as an oestrogen precursor. However, the tumour tissue converted androstenedione to oestrone and oestradiol-17\g=b\. The major metabolite of progesterone was 20\g=a\-hydroxypregn-4-en-3-one.These results are discussed in relation to current theories of the synthesis of steroids in the ovary.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 95%

Steroid Biosynthesis 'In Vitro' by Granulosa-Theca Cell Tumour Tissue

Griffiths¹,

Grant²,

Symington³

1964

Journal of Endocrinology

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Granulosa-Theca-Cell Tumor of the Ovary in Children

Zangeneh¹

1968

Arch Pediatr Adolesc Med

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WITHIN RECENT years granulosa\x=req-\ theca-cell tumors have attracted much interest, primarily because of their hormonal function. These tumors are the principal feminizing neoplasms of the ovary; and it has been emphasized that when they occur in prepubertal females, they almost always cause sexual precocity. Because of this known and rather constant relationship, the diagnosis of granulosa-theca-cell tumor usually is entertained in the differential diagnosis of isosexual precocity in females. Although it is appropriate that some consideration should be given to this diagnosis in all such patients, it should be remembered that not more than 10% of cases of sexual precocity in the female arise from ovarian tumors.The purpose of this article is to review the literature on this interesting problem, especially as it relates to children, and to emphasize the pitfalls in making the diagnosis. IncidenceThe rarity of granulosa-theca-cell tumors of the ovary is appreciated if it is remembered that primary ovarian tumors are rare, and that of these the granulosatheca-cell variety constitute only about

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