Granulomatous syringotropic mycosis fungoides with two lesions having reactive B‐cell proliferation

Wang, Lei; Wang, Gang; Gao, Tianwen

doi:10.1111/cup.12284

Cited by 8 publications

(8 citation statements)

References 25 publications

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“…8 Moreover, while the clinicopathologic importance of differentiating STMF from FMF is well established in the clinical dermatologic literature, it is notably missing from the dermatopathology literature. 9 …”

Section: Introductionmentioning

confidence: 99%

Syringotropic Mycosis Fungoides: A Rare Form of Cutaneous T-cell Lymphoma Enabling a Histopathologic “Sigh of Relief”

Lehmer¹,

Amber

Feraudy

2017

The American Journal of Dermatopathology

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Syringotropic mycosis fungoides (STMF) is a very rare variant of cutaneous T-cell lymphoma (CTCL). It follows a much milder disease course than its clinically indistinguishable adnexal counterpart, folliculotropic mycosis fungoides (FMF). We report a case of a 36-year-old male who presented with erythematous, studded papules and plaques on the left upper extremity and right anterior thigh diagnosed as MF Stage 1A on initial superficial shave biopsy. Lesions recurred after initial improvement with narrow band ultraviolet light therapy demonstrating a concentration of abnormal lymphocytes around eccrine sweat glands on repeat biopsy, consistent with STMF. While the deeper, periadnexal infiltrate found in both STMF and FMF confers increased resistance to skin-directed therapies effective in classic MF, these entities diverge with respect to their clinical behavior. Syringotropism is a marker for increased disease specific survival whereas even FMF carries a prognosis worse than conventional MF. Increased awareness amongst the dermatopathology community of the histopathologic distinction between STMF and FMF is essential to guide treatment type, duration, and intensity in adnexal disease.

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Section: Introductionmentioning

confidence: 99%

Syringotropic Mycosis Fungoides: A Rare Form of Cutaneous T-cell Lymphoma Enabling a Histopathologic “Sigh of Relief”

Lehmer¹,

Amber

Feraudy

2017

The American Journal of Dermatopathology

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“…Beside from typical MF, there are numerous clinical and pathological variants, including folliculotropic MF ( 10 ), SMF ( 2 , 6 , 7 , 11 ) and granulomatous MF ( 12 ). The present case is a rare SMF with reactive B cell proliferation and lymphoid follicle formation ( 5 ).…”

Section: Discussionmentioning

confidence: 88%

“…Early-stage SMF is treated with narrowband (311 nm) ultraviolet therapy ( 2 ). To date, only a limited number of SMF cases have been reported in the literature ( 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

“…Solitary, erythematous, punctate and anhidrotic patches are often clinically observed in the syringotropic form ( 4 , 6 ). Currently, the main recommended treatments for SMF are extracorporeal phototherapy and total skin electron beam therapy ( 2 , 5 , 7 ). The present study reported a case of rapidly progressive SMF with alopecia and lymphadenopathy.…”

Section: Introductionmentioning

confidence: 99%

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Syringotropic mycosis fungoides responding well to VELP chemotherapy: A case report

Luo

Zhang

Sun

et al. 2016

Experimental and Therapeutic Medicine

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Mycosis fungoides (MF), a low-malignant lymphoproliferative disorder, is the most common type of cutaneous T-cell lymphoma. The current study reported a case of syringotropic MF, a rare variant of MF, which presented with reactive B cell proliferation, lymphoid follicle formation, hair loss and lymphadenopathy. The clinical manifestations of the patient were MF-like lumps. Immunohistochemical staining of AE1/AE3 showed that there were abundant infiltrated lymphocytes surrounding the syringocystadenoma. In addition, the direction of the lymphocyte arrangement was consistent with the meandering direction of syringocystadenoma. The patient did not respond to 1-month narrowband (311-nm) ultraviolet therapy; however, a good response was obtained subsequent to one cycle of chemotherapy with vincristine sulfate, etoposide, L-asparaginase and prednisone acetate (know as the VELP regimen). After 7 days of VELP chemotherapy, the skin lesions were ameliorated, hair loss was improved and lymphadenopathy disappeared. No lymphadenopathy or new skin lesions were observed during 6 months of follow-up.

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“…However, the diagnosis of MF may be very difficult in certain cases, particularly in those variants of MF such assyringotropic MF, granulomatous MF and folliculotropic MF. 1 Folliculotropic MF is a rare variant, which histopathologically is characterized by pronounced folliculotropism of neoplastic T cells, with or without follicular mucinosis, and clinically by an im-…”

mentioning

confidence: 99%

Folliculotropic Mycosis Fungoides Associated with Alopecia in a Case

Balevi¹,

Özdemır²,

Üstüner³

et al. 2017

Turkiye Klinikleri J Dermatol

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Granulomatous syringotropic mycosis fungoides with two lesions having reactive B‐cell proliferation

Cited by 8 publications

References 25 publications

Syringotropic Mycosis Fungoides: A Rare Form of Cutaneous T-cell Lymphoma Enabling a Histopathologic “Sigh of Relief”

Syringotropic Mycosis Fungoides: A Rare Form of Cutaneous T-cell Lymphoma Enabling a Histopathologic “Sigh of Relief”

Syringotropic mycosis fungoides responding well to VELP chemotherapy: A case report

Folliculotropic Mycosis Fungoides Associated with Alopecia in a Case

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