Granulomatous pigmented purpuric dermatosis: an unusual variant associated with hyperlipidemia

Hanson, Cody; Fraga, Garth; Rajpara, Anand

doi:10.5070/d3212023831

Cited by 3 publications

(8 citation statements)

References 13 publications

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“…Granulomatous PPD is a rare subtype of PPD that is typically seen in women of Far East Asian descent on the distal lower extremities and feet 1–3. Saito and Matsuoka reported granulomatous PPD for the first time in 1996 4.…”

Section: Descriptionmentioning

confidence: 99%

“…The condition is usually distinguished from other types of PPDs by the detection of a granulomatous infiltrate on histopathology in addition to the other features of PPD 1 3 4. This variant has been associated with hyperlipidaemia, although this association is unclear and requires further investigation 2. Other frequent findings described are arterial hypertension and diabetes mellitus 2 5.…”

Section: Descriptionmentioning

confidence: 99%

“…This variant has been associated with hyperlipidaemia, although this association is unclear and requires further investigation 2. Other frequent findings described are arterial hypertension and diabetes mellitus 2 5. The differential diagnosis of PPDs includes cutaneous vasculitis, stasis dermatitis, traumatic purpura and mycosis fungoides 1.…”

Section: Descriptionmentioning

confidence: 99%

“…The differential diagnosis of PPDs includes cutaneous vasculitis, stasis dermatitis, traumatic purpura and mycosis fungoides 1. Treatment is not always necessary and is generally considered for patients with associated symptoms or because the cosmetic appearance of the skin lesions 2…”

Section: Descriptionmentioning

confidence: 99%

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Granulomatous pigmented purpuric dermatosis

et al. 2021

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Section: Descriptionmentioning

confidence: 99%

Section: Descriptionmentioning

confidence: 99%

Section: Descriptionmentioning

confidence: 99%

Section: Descriptionmentioning

confidence: 99%

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Granulomatous pigmented purpuric dermatosis

et al. 2021

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“…The granulomatous variant of PPD (GPPD) was first reported by Saito and Matsuoka in 1996 5 . Since then, only 40 cases of GPPD have been reported in the English literature 3,5‐30 . GPPD clinically presents as persistent, red to brown purpuric macules or papules, mostly involving the lower legs.…”

Section: Introductionmentioning

confidence: 99%

Granulomatous pigmented purpuric dermatosis: Clinical and histopathologic findings in a series of nine cases

2022

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We report the largest case series to date of granulomatous pigmented purpuric dermatosis (GPPD), a rare variant of pigmented purpuric dermatoses (PPD). GPPD can cause diagnostic difficulties as it can be mistaken clinically and histopathologically with numerous inflammatory and infectious dermatoses or even cutaneous T‐cell lymphoma. We compared the histopathological findings of nine cases of GPPD with a control group consisting of 10 randomly selected PPD of other subtypes. GPPD seems to predominantly affect the lower extremities of adult male patients; a clear association with hyperlipidemia or other systemic conditions could not be confirmed. Histopathologically, GPPD is characterized by a dermal histiocyte‐rich interstitial infiltrate with or without granuloma formation, thickened capillaries, extravasated erythrocytes, and/or hemosiderin deposits. In contrast to other forms of PPD, the inflammatory infiltrate of GPPD can extend to the mid or deep dermis and the admixed lymphocytic infiltrate is mainly composed of CD8+ T‐cells.

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Granulomatous Pigmented Purpuric Dermatosis in a Patient with (Inactive) Myasthenia Gravis: A Case Report and Review of the Literature

Dhekariyapak,

Wattanakrai

2023

Case Rep Dermatol

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Granulomatous pigmented purpuric dermatosis (GPPD) is a rare histologic variant of pigmented purpuric dermatosis (PPD) characterized by dermal histiocyte-rich interstitial infiltration with or without granuloma formation in addition to the other typical features of PPD. GPPD was previously observed more frequently to affect Asians and was reported to be associated with dyslipidemia. However, our literature search of 45 documented GPPD cases revealed an increasing prevalence in Caucasians in addition to dyslipidemia and associated autoimmune diseases. To date, etiopathogenesis of GPPD is unknown but may involve dyslipidemia, genetic and immunological factors such as autoimmune dysregulation or a sarcoidal reaction associated with <i>C. acnes</i>. GPPD is usually persistent and recalcitrant to treatments. We report a case of GPPD in a 57-year-old Thai woman with underlying myasthenia gravis who presented with a pruritic eruption on both lower legs. After treatment with 0.05% clobetasol propionate cream and oral colchicine, the lesion improved with marked flattening and disappeared with residual postinflammatory hyperpigmentation. We provide a literature review of the epidemiology, etiopathogenesis, concomitant comorbidities, clinical symptoms, dermatoscopic features, and treatments of GPPD.

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Granulomatous pigmented purpuric dermatosis: an unusual variant associated with hyperlipidemia

Cited by 3 publications

References 13 publications

Granulomatous pigmented purpuric dermatosis

Granulomatous pigmented purpuric dermatosis

Granulomatous pigmented purpuric dermatosis: Clinical and histopathologic findings in a series of nine cases

Granulomatous Pigmented Purpuric Dermatosis in a Patient with (Inactive) Myasthenia Gravis: A Case Report and Review of the Literature

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