Granulomatous hepatitis associated with chronic Borrelia burgdorferi infection: a case report

Middelveen, Marianne J; McClain, Steve A.; Bandoski, Cheryl; Israel, Joel R.; Burke, Jennie; MacDonald, Alan B.; Timmaraju, Arun; Sapi, Eva; Wang, Yean; Franco, A.; Mayne, Peter; Stricker, Raphael B.

doi:10.13070/rs.en.1.875

Cited by 18 publications

(31 citation statements)

References 3 publications

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“…This can eventuate into a virulent Lyme spirochetosis that can be problematic and difficult to treat. Persistence of B. burgdorferi has been well documented in a least 12 different mammalian hosts, including humans (Schmidli et al 1988;Priem et al 1998, Li et al 2011Hodzic et al 2014;Middelveen et al 2014). Pathologically, B. burgdorferi can not only circumvent and evade the human immune system but, at the same time, invade host tissue (Kraiczy et al 2001) and cause inflammation (Ramesh et al 2013).…”

Section: Borrelia Burgdorferi-infected I Scapularis On Songbirds In mentioning

confidence: 99%

New records of the Lyme disease bacterium in ticks collected from songbirds in central and eastern Canada

Scott¹,

Durden

2015

International Journal of Acarology

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This study highlights the collection of ticks from wild-caught birds in central and eastern Canada. Using polymerase chain reaction (PCR), 32 (33%) of 98 Ixodes species ticks tested were positive for the Lyme disease bacterium, Borrelia burgdorferi sensu lato (s.l.) Johnson, Schmid, Hyde, Steigerwalt, and Brenner (hereafter B. burgdorferi). Immature blacklegged ticks, Ixodes scapularis Say, which are competent vectors of B. burgdorferi, constituted the predominant Ixodes species tick collected from parasitized songbirds; specifically, 31(35%) of 89 I. scapularis nymphs were positive for B. burgdorferi. Notably, we report the first B. burgdorferi-positive I. scapularis (nymph) on a migratory passerine in Prince Edward Island; this is the first record of a tick on a bird in this maritime province. First-time records of B. burgdorferi-infected, I. scapularis nymphs on passerines in northwestern Ontario include rose-breasted grosbeak, Pheucticus ludovicianus (Linnaeus), eastern bluebird, Sialia sialis (L.), and indigo bunting, Passerina cyanea (L.). Similarly, we furnish a new host record in Canada for an I. scapularis (nymph) on a worm-eating warbler, Helmitheras vermivorus (Gmelin); this engorged nymph tested positive for B. burgdorferi. We document the first recorded collection of a B. burgdorferi-infected Ixodes muris Bishopp and Smith (female) on a songbird in Ontario. We provide the first account of a live culture of B. burgdorferi from an I. scapularis (nymph) collected from a brown-headed cowbird Molothrus ater (Boddaert) in Manitoba. We make available new host records for I. scapularis on a clay-coloured sparrow Spizella pallida (Swainson) and a Gambel's white-crowned sparrow Zonotrichia leucophrys gambelii (Nuttall). An I. scapularis on a songbird during southward autumn migration in northwestern Ontario is a first record reported. As well, we document the first-ever account of a reptile-associated tick, a nymph of Amblyomma sabanerae Stoll, on a veery Catharus fuscescens (Stephens) in northwestern Ontario. Migratory songbirds play an integral role in the wide dispersal of B. burgdorferi-infected ticks, especially during northward spring migration. Clinicians need to be aware that people can be bitten by B. burgdorferi-infected ticks released by songbirds across Canada.

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Section: Borrelia Burgdorferi-infected I Scapularis On Songbirds In mentioning

confidence: 99%

New records of the Lyme disease bacterium in ticks collected from songbirds in central and eastern Canada

Scott¹,

Durden

2015

International Journal of Acarology

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“…Consequently, it is misleading to reference antibody test results to validate a "theory" that autoimmunity, not persistent infection, is responsible for deteriorating/debilitating arthritis in chronic Lyme disease (1). Did Arvikar and colleagues utilize more advanced histopathologic staining, Borrelia culture, and molecular diagnostics to rule out persistent Borrelia infection in their study subjects (12)?…”

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Dion

Costédoat-Chalumeau

Piette

2017

Arthritis & Rheumatology

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“…For further comparison, additional controls were as follows: Liver from a mouse experimentally infected with Bb, used for positive comparison as previously described. 12,29 Negative controls included: a culture pellet of mixed Grampositive bacteria (Staphylococcus spp. and Micrococcus spp.)…”

Section: Histologymentioning

confidence: 99%

<p>Classification and Staging of Morgellons Disease: Lessons from Syphilis</p>

Middelveen

Martinez²,

Fesler

et al. 2020

CCID

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Introduction: Morgellons disease (MD) is a contested dermopathy that is associated with Borrelia spirochetal infection. A simple classification system was previously established to help validate the disease based on clinical features (classes I-IV). Methods: Drawing on historical and pathological parallels with syphilis, we formulated a more detailed staging system based on clinical features as well as severity of skin lesions and corresponding histopathological infection patterns, as determined by anti-Borrelia immunohistochemical staining. Results: Clinical classes I-IV of MD are further categorized as mild, moderate and severe, or stages A, B and C, respectively, based on histopathological findings. Stage A lesions demonstrated little or no immune infiltrates and little or no disorganization of cells; macrophages were not present, and hemorrhage was negligible. Extracellular isolated spirochetes and intracellular staining of keratinocytes in the lower epidermis was occasionally seen. Stage C lesions demonstrated positive staining of keratinocytes in the stratum basale and stratum spinosum and positive intracellular staining of macrophages for Borrelia. Aggregate Borrelia colonies were frequently encountered, hemorrhage was frequent, and intracellularly stained fibroblasts were occasionally seen. Stage B lesions demonstrated a pattern intermediate between Stages A and C. Conclusion: The enhanced staging system provides objective criteria to assess the severity of dermopathy in MD. Further studies are needed to determine the optimal treatment for MD based on this staging system related to Borrelia infection.

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Granulomatous hepatitis associated with chronic Borrelia burgdorferi infection: a case report

Cited by 18 publications

References 3 publications

New records of the Lyme disease bacterium in ticks collected from songbirds in central and eastern Canada

New records of the Lyme disease bacterium in ticks collected from songbirds in central and eastern Canada

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<p>Classification and Staging of Morgellons Disease: Lessons from Syphilis</p>

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