Granulomatous Diseases of the Liver

Sharma, Shobha

doi:10.1016/b978-1-4160-3258-8.50043-7

Cited by 3 publications

(5 citation statements)

References 168 publications

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“…The frequency has been reported to be higher in specific groups such as patients with fever of unknown origin or those infected with HIV where granulomas are noted to be between 16%e75%. 11 In the United States, however, 75% of cases are a result of sarcoidosis, mycobacterial infection, primary biliary cirrhosis, and druginduced liver injury. 12e15 In India, it has been reported in retrospective analyses that tuberculosis was the most common cause (55%) of cases.…”

Section: Introductionmentioning

confidence: 99%

Granulomatous liver diseases: A review

Coash

Forouhar

et al. 2012

Journal of the Formosan Medical Association

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Granulomas that consist of focal accumulations of macrophages are commonly found in the liver due to stimulation of the immune system by a number of agents. Manifestations are variable depending on whether the underlying cause is a systemic disease or a primary hepatic granulomatous reaction. This article describes the common causes, presentation, histopathology, and manifestations of granulomatous diseases as well as various diagnostic and management strategies.

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Section: Introductionmentioning

confidence: 99%

Granulomatous liver diseases: A review

Coash

Forouhar

et al. 2012

Journal of the Formosan Medical Association

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“…The lesion pattern is a granulomatous inflammatory reaction with the formation of chronic granulomas, composed of aggregates of cells, epithelioid macrophages arranged in a collar surrounded by mononuclear cells and occasional plasma cells. The etiology is usually infectious (tuberculosis, brucellosis, fungal or parasitic), but may also develop in autoimmune disease, such as primary biliary cirrhosis and rheumatic fever, as well as having an unknown origin, such as sarcoidosis, or foreign body reaction in response to drug-induced toxicity [1,2]. …”

Section: Introductionmentioning

confidence: 99%

“…In order for a drug to be responsible for granulomatous hepatitis and make a definitive diagnosis of drug-induced liver injury (DILI), it is necessary to exclude other causes and demonstrate the improvement of the condition after stopping the offending drug [1]. Histologically, drug-induced hepatic granulomas are indistinguishable from those produced by other causes [3].…”

Section: Introductionmentioning

confidence: 99%

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Albendazole-induced granulomatous hepatitis: a case report

et al. 2013

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IntroductionDrug-related hepatotoxicity is a common medical problem with implications for health systems. It constitutes a cause of acute liver failure and, in many cases, is responsible for the rejection of new pharmacological agents during efficacy and safety studies. Risk factors, as well as pathogenesis of drug-induced liver injury, are poorly understood. The diagnosis of drug-induced liver injury is challenging; it is difficult to define the cause of drug hepatotoxicity due to the heterogeneity of the clinical presentation and the absence of established criteria for accurate and reproducible identification of drug-associated liver toxicity.Case presentationWe report the case of a 25-year-old Hispanic woman admitted to our Clinical Hepatology Unit with symptoms of acute hepatitis of unknown etiology. She was diagnosed with albendazole-induced granulomatous hepatitis after ruling out other possible causes, based on laboratory studies, liver biopsy, medical history, detailed drug history, and spontaneous improvement of her liver biochemical profile after medication withdrawal. This diagnosis was supported by the Council for International Organizations of Medical Sciences-Roussel Uclaf Causality Assessment Method, which showed a likely correlation between hepatocellular damage and drug toxicity as the etiology.ConclusionsOur patient’s suspected diagnosis was albendazole-induced granulomatous hepatitis with confirmatory histologic pattern. This case deserves particular attention due to the wide use of albendazole in our country (Colombia) and the prevalent medical issue of drug-related hepatotoxicity.

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“…Acute schistosomiasis (Katayama fever) is seen in people infected for the first time, typically children or travelers, and is caused by immune-complex deposition in the host tissues [45••,47]. However, fibrosis does not occur in everyone with chronic schistosomiasis, and it appears that the genetic composition of the host may play a role [48]. The chronic inflammatory changes in the portal vein radicles (and periportal tissue) result in "pipe stem fibrosis" (also referred to as Symmers' pipe-stem fibrosis).…”

Section: Mechanism Of Diseasementioning

confidence: 99%

Helminthic infections of the liver

Pockros

Capozza²

2004

Curr Gastroenterol Rep

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Human helminthic infestation is exceedingly common on a global scale, with as many as 1.5 to 2 billion people affected worldwide. Helminths (parasitic worms) that infect the liver and hepatobiliary system include nematodes (roundworms), cestodes (tapeworms), and trematodes (flatworms or flukes). The majority of morbidity and mortality from these infestations is caused by the host immune response to the larvae or adult worm. Helminthic disease manifestations vary from the extremes of asymptomatic carriage to cirrhosis and decompensated liver disease. Current basic science and clinical research focus on improvements in medical therapy, mass screening and chemoprophylaxis, and the development of preventative vaccine strategies.

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Granulomatous Diseases of the Liver

Cited by 3 publications

References 168 publications

Granulomatous liver diseases: A review

Granulomatous liver diseases: A review

Albendazole-induced granulomatous hepatitis: a case report

Helminthic infections of the liver

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