Granulomatous liver diseases: A review

Coash, Marcy; Forouhar, Faripour; Wu, Catherine H.; Wu, George Y.

doi:10.1016/j.jfma.2011.11.023

Cited by 73 publications

(81 citation statements)

References 58 publications

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“…The symptoms of granulomatous liver disease depend on the underlying disease. Patients are frequently asymptomatic and may not have laboratory evidence of hepatic dysfunction (14).…”

Section: Discussionmentioning

confidence: 99%

Hepatic granulomas in Turkey: A 6-year clinicopathological study of 35 cases

Şahin

Yılmaz²,

Arhan³

et al. 2014

Turk J Gastroenterol

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Background/Aims: Granulomas are focal aggregates of modified macrophages that are surrounded by a rim of lymphocytes and fibroblasts. The present study aimed to evaluate the prevalence and etiology of hepatic granulomas (HGs) in the Department of Gastroenterology with a wider population. Materials and Methods: We performed a retrospective study on 2662 liver biopsy specimens analyzed between 2005 and 2011 at Gazi University Department of Gastroenterology to determine the presence of HGs. Results: There were 16 cases with primary biliary cirrhosis, of whom 14 without any other causative etiology. There were 6 cases of sarcoidosis, 2 cases of Fasciola hepatica infection, 2 cases of hepatitis C, and 2 cases of hepatitis B. One case had both tuberculosis and rheumatoid arthritis and one case had both tuberculosis and brucellosis. There was also one case each of leishmaniasis and Hodgkin's lymphoma. The diagnosis of autoimmune hepatitis was found in two cases. One case had immune cholangiopathy. Conclusion: The leading causative etiology of HGs was primary biliary cirrhosis, followed by sarcoidosis. As a study performed in a center that accepts patient profiles throughout Turkey, tuberculosis took a minor part in HG etiology. A drug-affected or toxic case of HG was not observed.

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“…The symptoms of granulomatous liver disease depend on the underlying disease. Patients are frequently asymptomatic and may not have laboratory evidence of hepatic dysfunction (14).…”

Section: Discussionmentioning

confidence: 99%

Hepatic granulomas in Turkey: A 6-year clinicopathological study of 35 cases

Şahin

Yılmaz²,

Arhan³

et al. 2014

Turk J Gastroenterol

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“…This suggests that initial infection of HCV was sufficient to induce onset of liver inflammation, which persist 28 weeks post infection potentially due to other factors such as secondary infections; an observation also seen in some HCV patients who have achieved SVR but without improvement in liver inflammation [50]. One of the observations supporting this hypothesis is the presence of granulomatous inflammation, shown to be mediated by CD68 expressing monocyte/macrophages, and is consistent with a chronic viral infection phenotype [51,52]. This was accompanied by increased levels of MCP-1, a chemokine that functions by stimulating migration and infiltration of monocytes and macrophages (Fig 4J).…”

Section: Discussionmentioning

confidence: 84%

Hepatitis C virus mediated chronic inflammation and tumorigenesis in the Humanised Immune system and Liver mouse model

Zheng¹,

Sze²,

Keng³

et al. 2017

Journal of Hepatology

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“…Since the body needs energy, the liver triglycerides are converted into free fatty acids in the circulation and oxidized to produce metabolic energy. Several factors require the production of free fatty acids, among which are the hormones cortisol, adrenaline, and noradrenaline (released in situations of stress) (Moon et al, 2002), and toxins produced by pathogenic microorganisms, for example, Mycobacterium spp, Leishmania spp and Trypanosoma spp (Coash et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Hepatic steatosis in six-banded armadillo (Euphractus sexcinctus Linnaeus, 1758)

et al. 2018

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The six-banded armadillo (Euphractus sexcinctus) stands out among wild mammals due to the rare occurrence of spontaneous metabolic diseases. When altered, the liver, which is important in metabolism, may trigger a dysfunctional cascade, leading to hepatic steatosis. Here we describe a case of hepatic steatosis in a six-banded armadillo living in captivity. The female specimen was captured and donated to the Federal University of Piaui under SISBIO authorization nº53303. The animal was first referred for a veterinary clinical evaluation, and then euthanized following the ethical standards of the Federal Council of Veterinary Medicine. At the start of the dissection, the abdominal cavity was accessed and sections of all ex situ liver lobes, spleen and mandibular lymph node were subjected to routine histological processing; the results were photo documented. The anatomic and histopathological analysis confirmed the diagnosis of hepatic steatosis, which we propose is related to an infectious process as a result of the changes observed in the organs of the lymphoid system. This report of fatty liver disease in armadillo suggests an acute infectious process with lymphoid system involvement. Keywords: Euphractus sexcinctus, infectious, liver, six-banded armadillo, steatosis. Esteatose hepática em tatu-peba (Euphractus sexcinctus Linnaeus, 1758)Resumo: O tatu-verdadeiro (Euphractus sexcinctus) se destaca entre os mamíferos selvagens devido à rara ocorrência de doenças metabólicas espontâneas. Quando alterado, o fígado, que é importante no metabolismo, pode desencadear uma cascata disfuncional, levando a esteatose hepática. Foi descrito um caso de esteatose hepática em um tatu-verdadeiro vivendo em cativeiro. O espécime feminino foi capturado e doado para a Universidade Federal do Piauí sob a autorização SISBIO nº53303. O animal foi encaminhado para uma avaliação clínica veterinária e, depois, submetido à eutanásia seguindo os padrões éticos do Conselho Federal de Medicina Veterinária. No início da dissecção, acessou-se a cavidade abdominal e as seções de todos os lóbulos do fígado ex situ, do baço e do linfonodo mandibular foram submetidos ao processamento histológico de rotina. Os resultados foram fotomicrografados e documentados. A análise anatômica e histopatológica confirmou o diagnóstico de esteatose hepática, que está relacionada a um processo infeccioso como resultado das mudanças observadas nos órgãos do sistema linfóide. Este relatório de doença hepática gordurosa no armadillo sugere um processo infeccioso agudo com comprometimento do sistema linfático. Euphractus sexcinctus, infecção, fígado, tatu-verdadeiro, esteatose. Palavras-chaves:

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Granulomatous liver diseases: A review

Cited by 73 publications

References 58 publications

Hepatic granulomas in Turkey: A 6-year clinicopathological study of 35 cases

Hepatic granulomas in Turkey: A 6-year clinicopathological study of 35 cases

Hepatitis C virus mediated chronic inflammation and tumorigenesis in the Humanised Immune system and Liver mouse model

Hepatic steatosis in six-banded armadillo (Euphractus sexcinctus Linnaeus, 1758)

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