Granulocytosis-Promoting Extract of Mouse Tumor Tissue: Partial Purification

Delmonte, L; Liebelt, Robert A.

doi:10.1126/science.148.3669.521

Cited by 31 publications

(11 citation statements)

References 6 publications

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“…Several agents which induce a granulocytosis, apparently by releasing marrow granulocytes, have been described (17)(18)(19)(20). It is possible that cortisol acts by affecting one of these systems, that cortisol release is stimulated by these agents, or that there is no relationship betwen cortisol effects and these agenits.…”

Section: Resultsmentioning

confidence: 99%

Leukokinetic studies

Bishop¹,

Athens²,

Boggs³

et al. 1968

J. Clin. Invest.

263

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Section: Resultsmentioning

confidence: 99%

Leukokinetic studies

Bishop¹,

Athens²,

Boggs³

et al. 1968

J. Clin. Invest.

263

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“…About 30% of patients with solid tumors have elevated numbers of granulocytes in their peripheral blood (>8000/μl); granulocytosis is also common in tumor-bearing mice [100-108]. Growth of autochthonous or transplanted murine tumors is accompanied by splenic enlargement (Schreiber, K. and Schreiber, H. unpublished results and [109]).…”

Section: Cancers Induce Local and Systemic Stromal Changesmentioning

confidence: 99%

Targeting stroma to treat cancers

Engels

Rowley

Schreiber

2012

Seminars in Cancer Biology

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All cancers depend on stroma for support of growth. Leukemias, solid tumors, cancer cells causing effusions, metastases as well as micro-disseminated cancer cells release factors that stimulate stromal cells, which in turn produce ligands that stimulate cancer cells. Therefore, elimination of stromal support by destroying the stromal cells or by inhibiting feedback stimulation of cancer growth is in the focus of many evolving therapies. A stringent evaluation of the efficacy of stromal targeting requires testing in animal models. Most current studies emphasize the successes of stromal targeting rather than deciphering its limitations. Here we show that many of the stromal targeting approaches, while often reducing tumor growth rates, are rarely curative. Therefore, we will also discuss conditions where stromal targeting can eradicate large established tumors. Finally, we will examine still unanswered questions of this promising and exciting area of cancer research.

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“…Macrophage and granulocyte precursors proliferate in response to primary and transplanted tumors (9, 10) resulting in splenic enlargement caused by increased myeloid hematopoiesis. GCSF, GM-CSF and/or IL-6 (7, 11-13) released by tumors appear to be particularly important in inducing these systemic effects.…”

Section: Introductionmentioning

confidence: 99%

Adoptively Transferred Immune T Cells Eradicate Established Tumors despite Cancer-Induced Immune Suppression

Arina

Schreiber

Binder

et al. 2014

The Journal of Immunology

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Myeloid-derived CD11b+Gr1+ suppressor cells (MDSC) and tumor-associated macrophages (TAM) are considered a major obstacle for effective adoptive T cell therapy. Myeloid cells suppress naive T cell proliferation ex vivo and can prevent the generation of T cell responses in vivo. We find, however, that immune T cells adoptively transferred eradicate well-established tumors in the presence of MDSC and TAM which are strongly immunosuppressive ex vivo. These MDSC and TAM were comparable in levels and immunosuppression among different tumor models. Longitudinal microscopy of tumors in vivo revealed that after T cell transfer tumor vasculature and cancer cells disappeared simultaneously. During T-cell mediated tumor destruction, the tumor stroma contained abundant myeloid cells (mainly TAM) that retained their suppressive properties. Preimmunized but not naive mice resisted immune suppression caused by an unrelated tumor-burden supporting the idea that in vivo, myeloid immunosuppressive cells can suppress naive but not memory T cell responses.

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Granulocytosis-Promoting Extract of Mouse Tumor Tissue: Partial Purification

Cited by 31 publications

References 6 publications

Leukokinetic studies

Leukokinetic studies

Targeting stroma to treat cancers

Adoptively Transferred Immune T Cells Eradicate Established Tumors despite Cancer-Induced Immune Suppression

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