Granulocytic Sarcoma of the Spine: MRI and Clinical Review

Seok, Jee Hyun; Park, Jeongmi; Kim, Sun Ki; Choi, Jung Eun; Kim, Choon-Choo

doi:10.2214/ajr.09.3086

Cited by 54 publications

(37 citation statements)

References 20 publications

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“…MS can occur in any organ, with common sites including the bones, lymph nodes, soft tissue and skin (9,10). Spinal epidural MS is not common, and spinal cord compression caused by MS is even more rare (11). Patients with MS have been shown to have a significantly higher rate of relapse and a significantly lower 5-year disease-free survival than patients without MS (3).…”

Section: Introductionmentioning

confidence: 99%

Acute Myeloid Leukemia Concurrent with Spinal Epidural Extramedullary Myeloid Sarcoma Accompanied by a High CD25 Expression and the <i>FLT3-ITD</i> Mutation

et al. 2014

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Myeloid sarcoma (MS) is an extramedullary myeloid tumor that sometimes presents with antedating systemic leukemia, leading physicians to the misdiagnosis of lymphoma. CD25 is expressed in 13% of patients with acute myeloid leukemia (AML), and its expression is associated with FLT3-ITD mutations, an elevated serum soluble interleukin 2 receptor (sIL-2R) level and a lower survival rate. However, there are no reports concerning the relationship between MS and the CD25 expression. We herein report a case of AML accompanied by thoracic epidural MS with a high CD25 expression, the FLT3-ITD mutation and an extremely elevated serum sIL-2R level in a 59-year-old man who presented with paraplegia.

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Section: Introductionmentioning

confidence: 99%

Acute Myeloid Leukemia Concurrent with Spinal Epidural Extramedullary Myeloid Sarcoma Accompanied by a High CD25 Expression and the <i>FLT3-ITD</i> Mutation

et al. 2014

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“…Spinal GS is extremely rare. It has been reported that the prevalence of GS in the spine is 1.0% among all patients with myeloid leukemia (7). GS in the absence of clinically detectable leukemia is not common and only a few cases of GS in patients without leukemia have been observed with spinal involvement (8,9).…”

Section: Discussionmentioning

confidence: 99%

“…An early and precise diagnosis of spinal GS with MRI evaluation facilitates appropriate treatment with further therapy (7). However, MRI is unable to evaluate the metabolism.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and treatment of a patient with isolated spinal granulocytic sarcoma: A case report

Xiao¹,

Long²,

Xiong³

et al. 2013

Oncology Letters

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A previously healthy 34-year-old female presented with a 5-month history of progressive backache and weakness in the left fingers. Magnetic resonance imaging (MRI) showed soft tissue masses in the spinal canal distributed along the nerve course. The patient’s baseline laboratory data were normal. Surgical intervention was performed and histological examination identified isolated spinal granulocytic sarcoma (GS). A bone marrow biopsy also presented normal findings. However, the patient developed numbness and pain in the right lower limb two months later. Fluorodeoxyglucose (FDG)-positron emission tomography (PET) showed FDG uptake in the left trapezius muscle, cervix uteri, iliac bone, lymphadenectasis of the pelvic wall and left axillary fossa. Cerebrospinal fluid (CSF) examination allowed a diagnosis of central nervous system leukemia (CNSL). The patient underwent chemotherapy and intrathecal injection, resulting in the elimination of the residual lesion. Correct diagnosis and adequate treatment are essential to achieve optimal results in patients with isolated spinal GS.

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“…schwannoma). 8 In association with leukemia, imaging findings of multiple or contiguous multilevel extramedullary spinal masses with diffuse, abnormal bone marrow signal intensity is suggestive of MS. 8 MS should be considered when both a solitary dumbbell-shaped mass in the intervertebral foramen and diffuse bone marrow infiltration are seen on MRI. MS can be confused easily with neurogenic tumors such as schwannomas.…”

Section: Discussionmentioning

confidence: 99%

Low back pain and lumbar radiculopathy as harbingers of acute myeloid leukemia recurrence in a patient with myeloid sarcoma

Smith

Slimack

McClendon

et al. 2012

Journal of Clinical Neuroscience

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Granulocytic Sarcoma of the Spine: MRI and Clinical Review

Abstract: Knowledge of the imaging findings of spinal granulocytic sarcoma, which consists of multiple extramedullary masses with diffuse leukemic bone marrow infiltration, can lead to early diagnosis and appropriate treatment to reduce neurologic symptoms.

Cited by 54 publications

References 20 publications

Acute Myeloid Leukemia Concurrent with Spinal Epidural Extramedullary Myeloid Sarcoma Accompanied by a High CD25 Expression and the <i>FLT3-ITD</i> Mutation

Acute Myeloid Leukemia Concurrent with Spinal Epidural Extramedullary Myeloid Sarcoma Accompanied by a High CD25 Expression and the <i>FLT3-ITD</i> Mutation

Diagnosis and treatment of a patient with isolated spinal granulocytic sarcoma: A case report

Low back pain and lumbar radiculopathy as harbingers of acute myeloid leukemia recurrence in a patient with myeloid sarcoma

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