Low back pain and lumbar radiculopathy as harbingers of acute myeloid leukemia recurrence in a patient with myeloid sarcoma

Smith, Timothy R.; Slimack, Nicholas P.; McClendon, Jamal; Wong, Ashley; Fessler, Richard G.

doi:10.1016/j.jocn.2011.11.012

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…Alive and in remission 6 [8] 64/M T6-T9 bilateral neural foramina, epidural space, and paraspinal tissue Cauda equina syndrome Radiotherapy and systemic chemotherapy Deceased 4 months later 7 [10] 28…”

Section: Chemotherapy Radiation Allogeneic Transplantmentioning

confidence: 99%

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Myeloid sarcoma of the thoracic spine: A case report

Patel

Uzoaru

Sutton

et al. 2023

Surgical Neurology International

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Background: Myeloid sarcoma is an uncommon malignant neoplasm that typically arises at extramedullary sites and is associated with a diagnosis of acute myeloid leukemia. While myeloid sarcoma can involve any organ, central nervous system involvement is rare, particularly in the adult population. Case Description: An 87-year-old female presented with progressive paraparesis of 5 days’ duration. The magnetic resonance imaging (MRI) revealed an epidural tumor from T4 to T7 with cord compression. When she underwent a laminectomy for tumor resection, the pathology revealed a myeloid sarcoma with monocytic differentiation. Although she improved postoperatively, she elected to pursue hospice care and expired 4 months later. Conclusion: Myeloid sarcoma is an uncommon malignant spinal neoplasm rarely seen in adults. For this 87-year-old female, MRI-documented cord compression warranted decompressive surgery. Although this patient did not opt for adjuvant therapy, other patients with such lesions may undergo additional chemotherapy or radiation therapy. Nevertheless, optimal management for such malignant tumor is still undefined.

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Section: Chemotherapy Radiation Allogeneic Transplantmentioning

confidence: 99%

“…[7] It is commonly associated with myeloid neoplasms such as acute myeloid leukemia (AML). [2][3][4]6,10] Within the central nervous system (CNS), involvement with the spinal cord is more frequent than with the brain. [7] Epidural involvement only occurs in about 0.2% of patients with AML.…”

Section: Introductionmentioning

confidence: 99%

Myeloid sarcoma of the thoracic spine: A case report

Patel

Uzoaru

Sutton

et al. 2023

Surgical Neurology International

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“…[8] Most chloromas are found in patients with recurrent acute myeloid leukemia (AML) and are typically intracranial, however, they can also rarely involve the spine. Although they can involve any organ system, few studies have reported isolated spinal involvement in patients without detectable AML.…”

Section: Introductionmentioning

confidence: 99%

“…Although they can involve any organ system, few studies have reported isolated spinal involvement in patients without detectable AML. [8]…”

Section: Introductionmentioning

confidence: 99%

A purely extradural lumbar nerve root cavernoma mimicking acute myeloid leukemia recurrence: Case report and literature review

et al. 2016

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Background:Myeloid sarcoma (MS) is a malignant tumor that usually occurs concomitantly with or following acute myeloid leukemia (AML). Cavernomas are benign congenital malformations that are unusual in the spine and exceedingly rare in pure extradural locations.Case Description:We report a 73-year-old female with a previous medical history of AML in remission for 3 years who presented with symptoms of low back pain and right lower extremity radiculopathy. A magnetic resonance scan showed an extradural, foraminal lesion centered at the L2 level involving the right L2 nerve root. In view of the history of AML, this lesion was potentially considered MS, a form of AML relapse. Surgery consisting of a right L1 and L2 hemilaminectomy facilitated gross total resection of the purely extradural lesion the proved histologically to be a cavernoma.Conclusion:In patients with a history of leukemia, MS must be considered in the differential diagnosis for any epidural or nerve root lesion that appears following treatment. Although rare, cavernomas must be considered among the differential diagnoses for epidural nerve root lesions in the setting of AML.

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Chloroma- Myelosarcoma or Leukemic Nerve Tumor?

Grisold¹,

Meng²

2016

J Leuk

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Low back pain and lumbar radiculopathy as harbingers of acute myeloid leukemia recurrence in a patient with myeloid sarcoma

Cited by 3 publications

References 7 publications

Myeloid sarcoma of the thoracic spine: A case report

Myeloid sarcoma of the thoracic spine: A case report

A purely extradural lumbar nerve root cavernoma mimicking acute myeloid leukemia recurrence: Case report and literature review

Chloroma- Myelosarcoma or Leukemic Nerve Tumor?

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