Granulocyte transfusions in neutropaenic children: A systematic review of the literature

Single-donor granulocyte transfusions for improving the outcome of high-risk pediatric patients with known bacterial and fungal infections undergoing stem cell transplantation: a 10-year single-center experience

“…We did not observe any significant acute toxicity after GTs. It goes in line with the Cochrane meta-analysis, 16 where adverse events occurred in 15% of patients without premedication as opposed to 0% in premedicated patients. No leukocyte compatibility tests were carried out in our institution.…”

“…Some studies have confirmed the decreased risk of adverse reactions and increased efficacy of GTs partially matched for HLA antigens and ABO groups. 6,15 Van de Watering et al 16 reported reduction of severe pulmonary toxicity after the introduction of the leukapheresis method for granulocyte collection.…”

Granulocyte transfusion experience in pediatric neutropenic fever: Splitted product can be an alternative?

“…Granulocyte transfusion (GTX) is one of the supportive treatment modalities which has been used for a long time [2] The principle of GTX is harvesting donors with granulocyte colony-stimulating factor (G-CSF) and dexamethasone for acquiring sufficient dose of granulocyte [3]. The technology to yield granulocyte product had improved within recent years.…”

Granulocyte transfusion therapy: randomization after all?

“…After irradiation of the granulocyte products, the risk of graft-versus-host disease has become insignificant. 9 Although rather counterintuitive, the impact of the presence or formation of antibodies against neutrophils on both the recovery of neutrophils following infusion and the clinical response and outcome of the patient seems to be limited, as will be discussed below.…”

“…This is a sufficient number to raise the circulating neutrophil count of severely neutropenic adults to almost normal levels, 8 and even above the doses recommended for pediatric patients. 9 Further studies showed that these cells also have normal functional characteristics and can migrate in vivo to the sites of inflammation. 10,11 Moreover, it was demonstrated that the neutrophils induced by G-CSF to circulate have a different transcriptional profile and, as a consequence of various pro-survival proteins, a much prolonged lifespan, which may be beneficial under clinical conditions.…”