Granulocyte transfusion therapy: randomization after all?

Drewniak, Agata; Kuijpers, Taco W.

doi:10.3324/haematol.2009.013680

Cited by 22 publications

(27 citation statements)

References 30 publications

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“…GTXs have also been used prophylactically in neutropenic patients despite the absence of solid evidence to support pre-emptive utilization of donor GTXs (62, 70). However, results of the few published studies reported positive outcome but no significant difference with respect to duration of hospitalization or 100-day survival has been reported (62, 70). …”

Section: Donor Granulocyte Transfusion Therapymentioning

confidence: 99%

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Infections Caused by Acinetobacter baumannii in Recipients of Hematopoietic Stem Cell Transplantation

Al-Anazi

Al-Jasser

2014

Front. Oncol.

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Acinetobacter baumannii (A. baumannii) is a Gram-negative, strictly aerobic, non-fermentative coccobacillus, which is widely distributed in nature. Recently, it has emerged as a major cause of health care-associated infections (HCAIs) in addition to its capacity to cause community-acquired infections. Risk factors for A. baumannii infections and bacteremia in recipients of hematopoietic stem cell transplantation include: severe underlying illness such as hematological malignancy, prolonged use of broad-spectrum antibiotics, invasive instrumentation such as central venous catheters or endotracheal intubation, colonization of respiratory, gastrointestinal, or urinary tracts in addition to severe immunosuppression caused by using corticosteroids for treating graft versus host disease. The organism causes a wide spectrum of clinical manifestations, but serious complications such as bacteremia, septic shock, ventilator-associated pneumonia, extensive soft tissue necrosis, and rapidly progressive systemic infections that ultimately lead to multi-organ failure and death are prone to occur in severely immunocompromised hosts. The organism is usually resistant to many antimicrobials including penicillins, cephalosporins, trimethoprim–sulfamethoxazole, almost all fluoroquinolones, and most of the aminoglycosides. The recently increasing resistance to carbapenems, colistin, and polymyxins is alarming. Additionally, there are geographic variations in the resistance patterns and several globally and regionally resistant strains have already been described. Successful management of A. baumannii infections depends upon appropriate utilization of antibiotics and strict application of preventive and infection control measures. In uncomplicated infections, the use of a single active beta-lactam may be justified, while definitive treatment of complicated infections in critically ill individuals may require drug combinations such as colistin and rifampicin or colistin and carbapenem. Mortality rates in patients having bacteremia or septic shock may reach 70%. Good prognosis is associated with presence of local infection, absence of multidrug resistant strain, and presence of uncomplicated infection while poor outcome is associated with severe underlying medical illness, bacteremia, septic shock, multi-organ failure, HCAIs, admission to intensive care facilities for higher levels of care, and culture of certain aggressive genotypes of A. baumannii.

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Section: Donor Granulocyte Transfusion Therapymentioning

confidence: 99%

“…However, GTXs should be given in specific institutions according to well established and preferably standardized operational procedures in order to ensure safety of both donors and recipients (62). …”

Section: Donor Granulocyte Transfusion Therapymentioning

confidence: 99%

Infections Caused by Acinetobacter baumannii in Recipients of Hematopoietic Stem Cell Transplantation

Al-Anazi

Al-Jasser

2014

Front. Oncol.

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“…Nonetheless, the use of granulocyte transfusions has remained infrequent and only about 1000 granulocyte units are transfused per year in the US [1]. Recently, interest in granulocyte transfusions has increased for a variety of reasons, including the ability to collect granulocytes in higher numbers using granulocyte colony-stimulating factor (GCSF), an increased incidence of therapy-related neutropenia and a rise in antibiotic resistance [20]. Moreover, recent research suggests that granulocyte transfusions could be used as a treatment for cancer [9,15,27].…”

Section: Introductionmentioning

confidence: 99%

Membrane permeability of the human granulocyte to water, dimethyl sulfoxide, glycerol, propylene glycol and ethylene glycol

Vian

Higgins

2014

Cryobiology

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Granulocytes are currently transfused as soon as possible after collection because they rapidly deteriorate after being removed from the body. This short shelf life complicates the logistics of granulocyte collection, banking and safety testing. Cryopreservation has the potential to significantly increase shelf life; however, cryopreservation of granulocytes has proven to be difficult. In this study, we investigate the membrane permeability properties of human granulocytes, with the ultimate goal of using membrane transport modeling to facilitate development of improved cryopreservation methods. We first measured the equilibrium volume of human granulocytes in a range of hypo- and hypertonic solutions and fit the resulting data using a Boyle-van't Hoff model. This yielded an isotonic cell volume of 378 μm3 and an osmotically inactive volume of 165 μm3. To determine the permeability of the granulocyte membrane to water and cryoprotectant (CPA), cells were injected into well-mixed CPA solution while collecting volume measurements using a Coulter Counter. These experiments were performed at temperatures ranging from 4 to 37 °C for exposure to dimethyl sulfoxide, glycerol, ethylene glycol and propylene glycol. The best-fit water permeability was similar in the presence of all of the CPAs, with an average value at 21 °C of 0.18 μm atm−1 min−1. The activation energy for water transport ranged from 41 to 61 kJ/mol. The CPA permeability at 21 °C was 6.4, 1.0, 8.4 and 4.0 μm/min for dimethyl sulfoxide, glycerol, ethylene glycol and propylene glycol, respectively, and the activation energy for CPA transport ranged between 59 and 68 kJ/mol.

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“…Granulocyte transfusions (GTXs) constitute a promising adjuvant therapy in case of neutropenic and immunocompromised patients in which the exclusive use of modern antimicrobial drugs is ineffective. 1,2 To acquire a sufficient number of cells for transfusion purposes the donor is treated with a combination of G-CSF and dexamethasone (dexa) before the collection of the neutrophils by leukapheresis. 3,4 Clearly, for transfusions to be beneficial it is important that the donor granulocytes are functional.…”

Section: Introductionmentioning

confidence: 99%

Toll-like receptor–induced reactivity and strongly potentiated IL-8 production in granulocytes mobilized for transfusion purposes

Drewniak

Tool

Geissler

et al. 2010

Blood

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Granulocyte transfusion therapy: randomization after all?

Cited by 22 publications

References 30 publications

Infections Caused by Acinetobacter baumannii in Recipients of Hematopoietic Stem Cell Transplantation

Infections Caused by Acinetobacter baumannii in Recipients of Hematopoietic Stem Cell Transplantation

Membrane permeability of the human granulocyte to water, dimethyl sulfoxide, glycerol, propylene glycol and ethylene glycol

Toll-like receptor–induced reactivity and strongly potentiated IL-8 production in granulocytes mobilized for transfusion purposes

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