“…Despite the non-ideal thermodynamic nature of the solutions involved, solution models incorporating an ideal dilute assumption are prevalent in cryobiology [8,9,11,12,18,30,31,34,37,39,[61][62][63][64][65][68][69][70]. One commonly-used form of ideal model is to assume that the solution osmolality is equal to the total solute concentration [11,12,18,34,37,61,70].…”