Granulocyte-macrophage colony-stimulating factor enhances phagocytosis of bacteria by human neutrophils

Fleischmann, Jacob; Golde, David W.; Weisbart, Richard H.; Gasson, Judith C.

doi:10.1182/blood.v68.3.708.708

Cited by 306 publications

(49 citation statements)

References 13 publications

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“…Therefore, it is suggested that increased generation of active neutrophils is caused by the stimulation of hematopoietic bone marrow cells by DHP-induced CSFs in miniature pigs. In addition to the stimulatory effects of CSFs on hematopoietic progenitors, CSFs have been shown to augment phagocytic activity and superoxide generation of neutrophils (3,6). Taken together, it is suggested that although direct effect of DHP on peripheral blood leukocytes in vitro has not been determined because of its insoluble nature in medium, the enhanced phagocytic and killing activities of neutrophils in miniature pigs after injection with DHP are, at least in part, attributable to DHP-induced CSFs.…”

mentioning

confidence: 99%

Enhancement of Phagocytosis and Bactericidal Activity of Neutrophils in Miniature Pigs by Dihydroheptaprenol, a Synthetic Polyprenol Derivative

Araki

Suzuki

Ogura

et al. 1989

Microbiology and Immunology

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Dihydroheptaprenol (DHP), a synthetic polyprenol derivative, markedly stimulated the generation of peripheral blood neutrophils after intramuscular injection in miniature pigs.The generated neutrophils exhibited enhanced phagocytic activity against latex particles and also enhanced killing activity against Escherichia coli. The effective dose in miniature pigs (1.4 mg/kg) was markedly less than that required in mice (100 mg/kg). These results indicate that DHP induces resistance to some bacterial infections in pigs, suggesting the applicability of DHP for humans.

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mentioning

confidence: 99%

Enhancement of Phagocytosis and Bactericidal Activity of Neutrophils in Miniature Pigs by Dihydroheptaprenol, a Synthetic Polyprenol Derivative

Araki

Suzuki

Ogura

et al. 1989

Microbiology and Immunology

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“…It does invite speculation that despite an increase in F4 ⁄ 80 + cell infiltration to affected tissues, the functional activity of macrophages in the GM-CSF ) ⁄ ) mouse is compromised. This is supported by in vitro studies where a higher number of PMN were phagocytic to Staphylococcus aureus with GM-CSF pretreatment [21]. Furthermore, administration of GM-CSF has been shown to increase the expression of receptors CD11b, CD11c, FccRII [22] on macrophages and thus promotes the phagocytic abilities of macrophages.…”

Section: Discussionmentioning

confidence: 88%

The Role of Granulocyte Macrophage‐Colony Stimulating Factor in Gastrointestinal Immunity to Salmonellosis

2009

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Human Salmonella infection, in particular, typhoid fever is a highly infectious disease that remains a major public health problem causing significant morbidity and mortality. The outcome of these infections depends on the host’s immune response, particularly the actions of granulocytes and macrophages. Using a mouse model of human typhoid fever, with Salmonella typhimurium infection of wild type and granulocyte macrophage‐colony stimulating factor (GM‐CSF) knock out mice we show a delay in the onset of immune‐mediated tissue damage in the spleens and livers of GM‐CSF−/− mice. Furthermore, GM‐CSF−/− mice have a prolonged sequestration of S. typhimurium in affected tissues despite an increased production of F4/80+ effector cells. Moreover in the absence of GM‐CSF, a decrease in pro‐inflammatory cytokine expression of tumor necrosis factor‐α, interleukin‐12 (IL‐12) and IL‐18 was found, which may alter the host’s immune response to infection. GM‐CSF appears to play an important role in the pathogenesis of Salmonellosis, and may contribute significantly to the development of protective gastrointestinal mucosal immune responses against oral pathogens.

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“…CSFs have been found to activate reactive oxygen metabolism of PMNs [7,[24][25][26][27]. Furthermore, several groups have recently shown that GM-CSF in particular can enhance phagocytosis and killing activity of neutrophils and macrophages against pathogenic parasites [28][29][30][31]. More recently, Blanchard et al reported production of GM-CSF by Candidastimulated large granular lymphocytes (LGL) and such a product could stimulate PMNs to evince anti-Candida activity [32].…”

Section: Discussionmentioning

confidence: 99%

Granulocyte colony-stimulating factor potentiates anti-Candida albicans growth inhibitory activity of polymorphonuclear cells

Yamamoto

1993

FEMS Immunology and Medical Microbiology

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Granulocyte colony-stimulating factor (G-CSF) stimulates a subset of granulocyte colony forming cells and when administered to neutropenic individuals results in recovery of blood neutrophil numbers to normal levels. Therefore, G-CSF may be a useful therapeutic agent for infections in immunocompromised hosts. However, to date there has been only limited information that G-CSF activates the antimicrobial activity of neutrophils. In the present study, we found that recombinant G-CSF promotes the anti-Candida albicans activity of normal human blood polymorphonuclear (PMN) cells in vitro using both a 3H-glucose uptake procedure and a Candida colony counting assay. As little as 0.1 ng/ml G-CSF induced significant anti-Candida activity in the PMN cultures. G-CSF treatment also enhanced superoxide anion production by the PMNs in response to f-MLP as determined by the superoxide dismutase inhibitable cytochrome C reduction method. Such results show that G-CSF can promote the antimicrobial activity of peripheral blood PMNs against C. albicans.

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Granulocyte-macrophage colony-stimulating factor enhances phagocytosis of bacteria by human neutrophils

Cited by 306 publications

References 13 publications

Enhancement of Phagocytosis and Bactericidal Activity of Neutrophils in Miniature Pigs by Dihydroheptaprenol, a Synthetic Polyprenol Derivative

Enhancement of Phagocytosis and Bactericidal Activity of Neutrophils in Miniature Pigs by Dihydroheptaprenol, a Synthetic Polyprenol Derivative

The Role of Granulocyte Macrophage‐Colony Stimulating Factor in Gastrointestinal Immunity to Salmonellosis

Granulocyte colony-stimulating factor potentiates anti-Candida albicans growth inhibitory activity of polymorphonuclear cells

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