The Role of Granulocyte Macrophage‐Colony Stimulating Factor in Gastrointestinal Immunity to Salmonellosis

Coon, Charmere; Beagley, Kenneth W.; Bao, Shisan

doi:10.1111/j.1365-3083.2009.02279.x

Cited by 12 publications

(11 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The levels of GM‐CSF were significantly lower in continuously exposed mice at PND259, and removal of the TCE had no effect on this marker. The production of GM‐CSF in the intestinal mucosa aids in the recruitment of dendritic cells, thus contributing protection against enteric bacterial pathogens (Coon, Beagley, & Bao, ; Hirata, Egea, Dann, Eckmann, & Kagnoff, ). The lower level of GM‐CSF may contribute to the higher abundance of bacteria representing the Enterobacteriaceae family.…”

Section: Discussionmentioning

confidence: 99%

Irreversible effects of trichloroethylene on the gut microbial community and gut‐associated immune responses in autoimmune‐prone mice

Khare

Gokulan

Williams

et al. 2018

J of Applied Toxicology

View full text Add to dashboard Cite

The developing immune system is particularly sensitive to immunotoxicants. This study assessed trichloroethylene (TCE)-induced effects on the gut microbiome and cytokine production during the development in mice. Mice were exposed to TCE (0.05 or 500 μg/mL) at the levels that approximate to environmental or occupational exposure, respectively. Mice were subjected to a continuous developmental exposure to these doses encompassing gestation, lactation and continuing directly in the drinking water postnatally for 154 days (PND154) or PND259. To observe persistence of the effect TCE was removed from the drinking water in a subset of mice on PND154 and were provided regular drinking water until the study terminus (PND259). Abundance of total tissue-associated bacteria reduced only in mice exposed to TCE until PND259. The ratio of Firmicutes/Bacteroidetes did not alter during this continuos exposure; however, cessation of high-dose TCE at PND154 resulted in the increased abundance Bacteroidetes at PND259. Furthermore, high-dose TCE exposure until PND259 resulted in a lower abundance of the genera Bacteroides and Lactobaccilus and increased abundance of genus Bifidobactrium and bacterial family Enterobacteriaceae. TCE exposure until PND154 showed significant changes in the production of interleukin-33; that might play a dual role in maintaining the balance and homeostasis between commensal microbiota and mucosal health. At PND259, interleukin-3, granulocyte-macrophage colony-stimulating factor and Eotaxin were altered in both, the continuous exposure and cessation groups, whereas only a cessation group had a higher level of KC that may facilitate infiltration of neutrophils. The irreversible effects of TCE after a period of exposure cessation suggested a unique programming and potential toxicity of TCE even at the environmental level exposure.

show abstract

Section: Discussionmentioning

confidence: 99%

Irreversible effects of trichloroethylene on the gut microbial community and gut‐associated immune responses in autoimmune‐prone mice

Khare

Gokulan

Williams

et al. 2018

J of Applied Toxicology

View full text Add to dashboard Cite

show abstract

“…In vitro, GM-CSF has previously been shown to induce IL-12 from both DCs and macrophages [30]. In addition, mice deficient in GM-CSF exposed either to a viral [31] or bacterial [32] pathogen demonstrated a reduction in IL-12 production. Furthermore, overexpression of GM-CSF in the lungs of normal mice stimulates an increase in IL-12 production [33].…”

Section: Discussionmentioning

confidence: 99%

A mouse GM-CSF receptor antibody attenuates neutrophilia in mice exposed to cigarette smoke

Botelho

Nikota

Bauer

et al. 2011

European Respiratory Journal

View full text Add to dashboard Cite

We investigated the role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in a subchronic exposure model of cigarette smoke (CS)-induced inflammation using antibodies directed against GM-CSF or the GM-CSF receptor (GM-CSFR) a-chain.CS-induced mononuclear and neutrophilic inflammation following 4 days of CS exposure in BALB/c mice was assessed in bronchoalveolar lavage (BAL) fluid. An increase in mature dendritic cells (DCs) (CD11c+ and major histocompatibility complex II+) and Gr-1-high neutrophils was also observed by flow cytometric analysis of whole-lung tissue.Daily i.p. injection of 400 mg GM-CSF or GM-CSFR antibody prior to daily smoke exposure attenuated the accumulation of neutrophils within the BAL by 60%. A reduction in mature DCs was also observed. Anti-GM-CSFR antibody administration did not have an effect on the percentage of lung T-cells; however, a significant decrease in activated CD69+ CD8+ T-cells was observed. Anti-GM-CSFR antibody administration decreased the mRNA and protein expression of interleukin-12 p40 and matrix metalloproteinase 12.Taken together, intervention with this receptor antibody implicates the GM-CSF pathway as an important mediator of smoke-induced inflammation.

show abstract

“…One study observed that GM-CSF −/− mice have impaired cytokine production in the intestine and delayed onset of inflammatory pathology in the spleen and liver during murine Salmonella -infection [11]. We recently investigated the specific role of GM-CSF in controlling intestinal inflammation and in host defense to enteric infection by Citrobacter rodentium [10].…”

Section: Gm-csf In Gastrointestinal Diseasementioning

confidence: 99%

GM-CSF: a role in immune and inflammatory reactions in the intestine

Egea

Hirata

Kagnoff

2010

Expert Review of Gastroenterology & Hepatology

View full text Add to dashboard Cite

Granulocyte macrophage colony-stimulating factor (GM-CSF) is a cytokine that promotes myeloid cell development and maturation, and dendritic cell differentiation and survival in vitro. Growing evidence supports the notion that GM-CSF has a major role in some inflammatory and autoimmune reactions and in the host’s response to pulmonary infection, but few studies have addressed its functions and importance in the GI tract. Recent studies demonstrated that administration of GM-CSF can result in clinical improvement in patients with Crohn’s disease. Mice deficient in GM-CSF (GM-CSF−/−) developed more severe intestinal and systemic infection after an enteric infection, and more severe colitis in response to enteric exposure to dextran sodium sulfate. Both the severity of infection and colitis were largely prevented by GM-CSF administration. Such studies indicate that GM-CSF has an important role in the regulation of intestinal immune and inflammatory responses.

show abstract

The Role of Granulocyte Macrophage‐Colony Stimulating Factor in Gastrointestinal Immunity to Salmonellosis

Cited by 12 publications

References 35 publications

Irreversible effects of trichloroethylene on the gut microbial community and gut‐associated immune responses in autoimmune‐prone mice

Irreversible effects of trichloroethylene on the gut microbial community and gut‐associated immune responses in autoimmune‐prone mice

A mouse GM-CSF receptor antibody attenuates neutrophilia in mice exposed to cigarette smoke

GM-CSF: a role in immune and inflammatory reactions in the intestine

Contact Info

Product

Resources

About